BRD-K03449891_foretinib_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

103 genes differentially expressed following the BRD-K03449891_foretinib_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALB albumin
ALCAM activated leukocyte cell adhesion molecule
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANXA4 annexin A4
APOA1 apolipoprotein A-I
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAALC brain and acute leukemia, cytoplasmic
BAX BCL2-associated X protein
BLNK B-cell linker
CCDC176 coiled-coil domain containing 176
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CES1 carboxylesterase 1
CETN2 centrin, EF-hand protein, 2
CFB complement factor B
CUTA cutA divalent cation tolerance homolog (E. coli)
CYFIP2 cytoplasmic FMR1 interacting protein 2
DSP desmoplakin
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
F5 coagulation factor V (proaccelerin, labile factor)
FAS Fas cell surface death receptor
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FGB fibrinogen beta chain
GAA glucosidase, alpha; acid
GJA1 gap junction protein, alpha 1, 43kDa
GSTA1 glutathione S-transferase alpha 1
IFI27 interferon, alpha-inducible protein 27
IRS1 insulin receptor substrate 1
ISG15 ISG15 ubiquitin-like modifier
LAMP2 lysosomal-associated membrane protein 2
LDLR low density lipoprotein receptor
MAGED2 melanoma antigen family D2
MSMO1 methylsterol monooxygenase 1
MYLK myosin light chain kinase
NEBL nebulette
ORAI3 ORAI calcium release-activated calcium modulator 3
ORC1 origin recognition complex, subunit 1
ORM1 orosomucoid 1
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PAWR PRKC, apoptosis, WT1, regulator
PDE4DIP phosphodiesterase 4D interacting protein
PON2 paraoxonase 2
PPAP2B phosphatidic acid phosphatase type 2B
PTN pleiotrophin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCD5 stearoyl-CoA desaturase 5
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SFRP1 secreted frizzled-related protein 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SPINK1 serine peptidase inhibitor, Kazal type 1
STC1 stanniocalcin 1
STOM stomatin
TFF1 trefoil factor 1
TM4SF4 transmembrane 4 L six family member 4
TOX3 TOX high mobility group box family member 3
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ASRGL1 asparaginase like 1
BRCA1 breast cancer 1, early onset
CAB39 calcium binding protein 39
CCNA2 cyclin A2
CDC25A cell division cycle 25A
CDC45 cell division cycle 45
CELF2 CUGBP, Elav-like family member 2
CENPA centromere protein A
CEP55 centrosomal protein 55kDa
CIT citron rho-interacting serine/threonine kinase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNM1L dynamin 1-like
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ESPL1 extra spindle pole bodies homolog 1 (S. cerevisiae)
FEN1 flap structure-specific endonuclease 1
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GSTP1 glutathione S-transferase pi 1
HSPA8 heat shock 70kDa protein 8
KIF14 kinesin family member 14
KIF18B kinesin family member 18B
LDHB lactate dehydrogenase B
LEF1 lymphoid enhancer-binding factor 1
LMNB1 lamin B1
LUM lumican
MAGEA3 melanoma antigen family A3
MELK maternal embryonic leucine zipper kinase
MKI67 marker of proliferation Ki-67
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRC1 protein regulator of cytokinesis 1
PRMT5 protein arginine methyltransferase 5
PRPF4 pre-mRNA processing factor 4
RANBP1 RAN binding protein 1
TBC1D4 TBC1 domain family, member 4
TIAM1 T-cell lymphoma invasion and metastasis 1