BRD-K03063480_PF-477736_PC3_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

83 genes differentially expressed following the BRD-K03063480_PF-477736_PC3_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
AREG amphiregulin
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF4 activating transcription factor 4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AVPI1 arginine vasopressin-induced 1
CARS cysteinyl-tRNA synthetase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CREM cAMP responsive element modulator
CTH cystathionine gamma-lyase
DDIT4 DNA-damage-inducible transcript 4
DLK1 delta-like 1 homolog (Drosophila)
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
E2F2 E2F transcription factor 2
FUCA1 fucosidase, alpha-L- 1, tissue
GARS glycyl-tRNA synthetase
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
IFITM1 interferon induced transmembrane protein 1
KRT18 keratin 18, type I
MOCOS molybdenum cofactor sulfurase
MSLN mesothelin
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR4A3 nuclear receptor subfamily 4, group A, member 3
NUPR1 nuclear protein, transcriptional regulator, 1
PAWR PRKC, apoptosis, WT1, regulator
PBX1 pre-B-cell leukemia homeobox 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCSK1 proprotein convertase subtilisin/kexin type 1
PDE4D phosphodiesterase 4D, cAMP-specific
PDLIM5 PDZ and LIM domain 5
PHGDH phosphoglycerate dehydrogenase
PPAP2B phosphatidic acid phosphatase type 2B
PSAT1 phosphoserine aminotransferase 1
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
RYBP RING1 and YY1 binding protein
SEPP1 selenoprotein P, plasma, 1
SERINC3 serine incorporator 3
SIK1 salt-inducible kinase 1
SLC38A1 solute carrier family 38, member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STC2 stanniocalcin 2
TGIF1 TGFB-induced factor homeobox 1
TRIB3 tribbles pseudokinase 3
TSPAN13 tetraspanin 13
WT1 Wilms tumor 1

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ADRB2 adrenoceptor beta 2, surface
ANXA1 annexin A1
BMP4 bone morphogenetic protein 4
CAPG capping protein (actin filament), gelsolin-like
CCP110 centriolar coiled coil protein 110kDa
CD59 CD59 molecule, complement regulatory protein
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
KRT14 keratin 14, type I
KRT5 keratin 5, type II
MGLL monoglyceride lipase
MNDA myeloid cell nuclear differentiation antigen
MT1E metallothionein 1E
PAN2 PAN2 poly(A) specific ribonuclease subunit
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A8 S100 calcium binding protein A8
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TIAM1 T-cell lymphoma invasion and metastasis 1