BRD-K03063480_PF-477736_MDAMB231_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

87 genes differentially expressed following the BRD-K03063480_PF-477736_MDAMB231_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CENPE centromere protein E, 312kDa
CFD complement factor D (adipsin)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
COTL1 coactosin-like F-actin binding protein 1
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DSP desmoplakin
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
GDF15 growth differentiation factor 15
GNG11 guanine nucleotide binding protein (G protein), gamma 11
HNMT histamine N-methyltransferase
IGFBP5 insulin-like growth factor binding protein 5
KIF14 kinesin family member 14
KRT7 keratin 7, type II
MKNK2 MAP kinase interacting serine/threonine kinase 2
MPPED2 metallophosphoesterase domain containing 2
NFIL3 nuclear factor, interleukin 3 regulated
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PEG3 paternally expressed 3
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PLA2G16 phospholipase A2, group XVI
PMP22 peripheral myelin protein 22
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SLC38A1 solute carrier family 38, member 1
SNX11 sorting nexin 11
SPP1 secreted phosphoprotein 1
STC2 stanniocalcin 2
STX1A syntaxin 1A (brain)
TGFBR3 transforming growth factor, beta receptor III
TLR4 toll-like receptor 4
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BMP4 bone morphogenetic protein 4
BZW2 basic leucine zipper and W2 domains 2
CDC42 cell division cycle 42
CDK5R1 cyclin-dependent kinase 5, regulatory subunit 1 (p35)
CFB complement factor B
CPE carboxypeptidase E
CRABP2 cellular retinoic acid binding protein 2
CXCL13 chemokine (C-X-C motif) ligand 13
CXCL14 chemokine (C-X-C motif) ligand 14
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1
FCGBP Fc fragment of IgG binding protein
FZD7 frizzled class receptor 7
GSTM3 glutathione S-transferase mu 3 (brain)
GUCY1A3 guanylate cyclase 1, soluble, alpha 3
HIST1H2BD histone cluster 1, H2bd
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
LAPTM4B lysosomal protein transmembrane 4 beta
LCN2 lipocalin 2
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MTSS1 metastasis suppressor 1
MYH10 myosin, heavy chain 10, non-muscle
NEB nebulin
NEFL neurofilament, light polypeptide
NPY1R neuropeptide Y receptor Y1
PCSK1 proprotein convertase subtilisin/kexin type 1
PDZD2 PDZ domain containing 2
PI3 peptidase inhibitor 3, skin-derived
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
RCAN2 regulator of calcineurin 2
SCG5 secretogranin V
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SNAP25 synaptosomal-associated protein, 25kDa
SOSTDC1 sclerostin domain containing 1
SPON2 spondin 2, extracellular matrix protein
STEAP1 six transmembrane epithelial antigen of the prostate 1
TCF4 transcription factor 4
TDO2 tryptophan 2,3-dioxygenase
THBD thrombomodulin
TMEM158 transmembrane protein 158 (gene/pseudogene)
TSPAN6 tetraspanin 6
TUBA4A tubulin, alpha 4a
VSNL1 visinin-like 1