BRD-K03063480_PF-477736_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

130 genes differentially expressed following the BRD-K03063480_PF-477736_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ANKRD10 ankyrin repeat domain 10
APOD apolipoprotein D
ARHGAP29 Rho GTPase activating protein 29
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
AURKA aurora kinase A
BAD BCL2-associated agonist of cell death
C3 complement component 3
C8ORF4 chromosome 8 open reading frame 4
CD14 CD14 molecule
CD44 CD44 molecule (Indian blood group)
CENPE centromere protein E, 312kDa
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CST1 cystatin SN
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCR4 chemokine (C-X-C motif) receptor 4
DCLK1 doublecortin-like kinase 1
EFNB2 ephrin-B2
FLRT3 fibronectin leucine rich transmembrane protein 3
FN1 fibronectin 1
FXYD5 FXYD domain containing ion transport regulator 5
HIST1H2BG histone cluster 1, H2bg
HMGA2 high mobility group AT-hook 2
IGFBP7 insulin-like growth factor binding protein 7
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KRT7 keratin 7, type II
LAMA3 laminin, alpha 3
LAMP5 lysosomal-associated membrane protein family, member 5
LAPTM5 lysosomal protein transmembrane 5
LGALS1 lectin, galactoside-binding, soluble, 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LUC7L3 LUC7-like 3 (S. cerevisiae)
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MEF2C myocyte enhancer factor 2C
MGP matrix Gla protein
MMP1 matrix metallopeptidase 1
MYBPC1 myosin binding protein C, slow type
NCAM1 neural cell adhesion molecule 1
NEB nebulin
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NFIB nuclear factor I/B
PAN2 PAN2 poly(A) specific ribonuclease subunit
PEG10 paternally expressed 10
PLK1 polo-like kinase 1
PNMA2 paraneoplastic Ma antigen 2
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PPP1R14B protein phosphatase 1, regulatory (inhibitor) subunit 14B
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SPP1 secreted phosphoprotein 1
SULF1 sulfatase 1
SYT1 synaptotagmin I
TARBP1 TAR (HIV-1) RNA binding protein 1
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFPI2 tissue factor pathway inhibitor 2
TIMP1 TIMP metallopeptidase inhibitor 1
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB6 tubulin, beta 6 class V
VIM vimentin
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ANKRD28 ankyrin repeat domain 28
APOBEC3A apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A
CADM1 cell adhesion molecule 1
CCNE2 cyclin E2
CHN1 chimerin 1
COMP cartilage oligomeric matrix protein
CST7 cystatin F (leukocystatin)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DHRS2 dehydrogenase/reductase (SDR family) member 2
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
GCA grancalcin, EF-hand calcium binding protein
GNPDA1 glucosamine-6-phosphate deaminase 1
GTPBP8 GTP-binding protein 8 (putative)
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IGL immunoglobulin lambda locus
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
KRT13 keratin 13, type I
KRT5 keratin 5, type II
LAPTM4B lysosomal protein transmembrane 4 beta
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LTBP1 latent transforming growth factor beta binding protein 1
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAN1A1 mannosidase, alpha, class 1A, member 1
MME membrane metallo-endopeptidase
MPO myeloperoxidase
MYLK myosin light chain kinase
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PHACTR2 phosphatase and actin regulator 2
PPIF peptidylprolyl isomerase F
PTN pleiotrophin
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RPA3 replication protein A3, 14kDa
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAGD Ras-related GTP binding D
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A9 S100 calcium binding protein A9
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene)
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SFN stratifin
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR3 small proline-rich protein 3
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
TFRC transferrin receptor
TNPO1 transportin 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
WBP5 WW domain binding protein 5
WFDC1 WAP four-disulfide core domain 1
WISP2 WNT1 inducible signaling pathway protein 2