BRD-K03063480_PF-477736_HS578T_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

98 genes differentially expressed following the BRD-K03063480_PF-477736_HS578T_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ADA adenosine deaminase
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ASCL1 achaete-scute family bHLH transcription factor 1
ATF3 activating transcription factor 3
BCL2A1 BCL2-related protein A1
BPHL biphenyl hydrolase-like (serine hydrolase)
C1ORF116 chromosome 1 open reading frame 116
CDC25A cell division cycle 25A
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN10 claudin 10
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
CNN3 calponin 3, acidic
CPB1 carboxypeptidase B1 (tissue)
CRIP1 cysteine-rich protein 1 (intestinal)
DCN decorin
DLK1 delta-like 1 homolog (Drosophila)
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
ETNPPL ethanolamine-phosphate phospho-lyase
FASTKD5 FAST kinase domains 5
FGFR3 fibroblast growth factor receptor 3
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
HBB hemoglobin, beta
HIST1H2AC histone cluster 1, H2ac
HOPX HOP homeobox
HRSP12 heat-responsive protein 12
IFNGR1 interferon gamma receptor 1
KRT14 keratin 14, type I
KRT23 keratin 23, type I
LRRC17 leucine rich repeat containing 17
LRRN3 leucine rich repeat neuronal 3
MAN1A1 mannosidase, alpha, class 1A, member 1
NEFH neurofilament, heavy polypeptide
NUPL1 nucleoporin like 1
ORM1 orosomucoid 1
PEG3 paternally expressed 3
RGCC regulator of cell cycle
RHOB ras homolog family member B
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCRG1 stimulator of chondrogenesis 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAR steroidogenic acute regulatory protein
TM4SF1 transmembrane 4 L six family member 1
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TPD52L1 tumor protein D52-like 1
TSPAN12 tetraspanin 12
XIST X inactive specific transcript (non-protein coding)
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
AIM1 absent in melanoma 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ARL4C ADP-ribosylation factor-like 4C
CD36 CD36 molecule (thrombospondin receptor)
CD93 CD93 molecule
CECR1 cat eye syndrome chromosome region, candidate 1
COLEC12 collectin sub-family member 12
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEGS1 delta(4)-desaturase, sphingolipid 1
E2F2 E2F transcription factor 2
EFS embryonal Fyn-associated substrate
EPB41L3 erythrocyte membrane protein band 4.1-like 3
ETV5 ets variant 5
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FADS1 fatty acid desaturase 1
FGL2 fibrinogen-like 2
HOXB7 homeobox B7
KCTD12 potassium channel tetramerization domain containing 12
KDM5D lysine (K)-specific demethylase 5D
LAP3 leucine aminopeptidase 3
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAP1B microtubule-associated protein 1B
MET MET proto-oncogene, receptor tyrosine kinase
MXRA5 matrix-remodelling associated 5
MYO10 myosin X
NRP1 neuropilin 1
PAN2 PAN2 poly(A) specific ribonuclease subunit
PDLIM1 PDZ and LIM domain 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SETBP1 SET binding protein 1
SIDT2 SID1 transmembrane family, member 2
SOBP sine oculis binding protein homolog (Drosophila)
SOX11 SRY (sex determining region Y)-box 11
SPP1 secreted phosphoprotein 1
STC1 stanniocalcin 1
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TRIB2 tribbles pseudokinase 2
ZFP36L1 ZFP36 ring finger protein-like 1