BRD-K03063480_PF-477736_HA1E_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

104 genes differentially expressed following the BRD-K03063480_PF-477736_HA1E_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CADM1 cell adhesion molecule 1
CCL4 chemokine (C-C motif) ligand 4
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLIC4 chloride intracellular channel 4
COL4A5 collagen, type IV, alpha 5
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXADR coxsackie virus and adenovirus receptor
CXCL2 chemokine (C-X-C motif) ligand 2
CYB561 cytochrome b561
DDB2 damage-specific DNA binding protein 2, 48kDa
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP2 dual specificity phosphatase 2
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGR1 early growth response 1
FDXR ferredoxin reductase
GADD45A growth arrest and DNA-damage-inducible, alpha
GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)
HES1 hes family bHLH transcription factor 1
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HIST1H2BK histone cluster 1, H2bk
HLA-C major histocompatibility complex, class I, C
HSPA6 heat shock 70kDa protein 6 (HSP70B')
ICAM1 intercellular adhesion molecule 1
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
KRT17 keratin 17, type I
KRT23 keratin 23, type I
METTL7A methyltransferase like 7A
PEG3 paternally expressed 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PRNP prion protein
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SESN1 sestrin 1
SLPI secretory leukocyte peptidase inhibitor
SOX9 SRY (sex determining region Y)-box 9
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
TIGAR TP53 induced glycolysis regulatory phosphatase
TIMP1 TIMP metallopeptidase inhibitor 1
TOB1 transducer of ERBB2, 1
TRIM22 tripartite motif containing 22
WARS tryptophanyl-tRNA synthetase
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ADAM10 ADAM metallopeptidase domain 10
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
CALR calreticulin
CD24 CD24 molecule
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL5A2 collagen, type V, alpha 2
DEFB1 defensin, beta 1
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
EPHB2 EPH receptor B2
FAM171A1 family with sequence similarity 171, member A1
FZD7 frizzled class receptor 7
GOLM1 golgi membrane protein 1
IGHD immunoglobulin heavy constant delta
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
IRS2 insulin receptor substrate 2
LBH limb bud and heart development
LIMS1 LIM and senescent cell antigen-like domains 1
LOX lysyl oxidase
LXN latexin
MAL mal, T-cell differentiation protein
MALL mal, T-cell differentiation protein-like
MGP matrix Gla protein
MUC4 mucin 4, cell surface associated
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F2 nuclear receptor subfamily 2, group F, member 2
NRN1 neuritin 1
PAX8 paired box 8
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PI3 peptidase inhibitor 3, skin-derived
PKM pyruvate kinase, muscle
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS23 protease, serine, 23
PTGIS prostaglandin I2 (prostacyclin) synthase
RHCG Rh family, C glycoprotein
S100A7 S100 calcium binding protein A7
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SPON1 spondin 1, extracellular matrix protein
TBC1D4 TBC1 domain family, member 4
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TGM2 transglutaminase 2
TKT transketolase
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VCAN versican