BRD-K03015355_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K03015355_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARID4B AT rich interactive domain 4B (RBP1-like)
BCL2 B-cell CLL/lymphoma 2
BEX1 brain expressed, X-linked 1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL1A1 collagen, type I, alpha 1
CPD carboxypeptidase D
CPE carboxypeptidase E
CTGF connective tissue growth factor
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DEFA4 defensin, alpha 4, corticostatin
DEPTOR DEP domain containing MTOR-interacting protein
DSP desmoplakin
DUSP4 dual specificity phosphatase 4
FADS1 fatty acid desaturase 1
GAS1 growth arrest-specific 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GUSBP11 glucuronidase, beta pseudogene 11
HIST1H2AC histone cluster 1, H2ac
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HOXA5 homeobox A5
IER3 immediate early response 3
IFITM3 interferon induced transmembrane protein 3
IGFBP3 insulin-like growth factor binding protein 3
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IGLV3-19 immunoglobulin lambda variable 3-19
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
LPGAT1 lysophosphatidylglycerol acyltransferase 1
LYZ lysozyme
MAGEA3 melanoma antigen family A3
MBTPS1 membrane-bound transcription factor peptidase, site 1
MMP12 matrix metallopeptidase 12
MSMO1 methylsterol monooxygenase 1
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PEG10 paternally expressed 10
PERP PERP, TP53 apoptosis effector
PLCB4 phospholipase C, beta 4
POSTN periostin, osteoblast specific factor
PSPH phosphoserine phosphatase
RAP1GAP RAP1 GTPase activating protein
RBP1 retinol binding protein 1, cellular
SCG2 secretogranin II
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SIK1 salt-inducible kinase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
TCEA2 transcription elongation factor A (SII), 2
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFF3 trefoil factor 3 (intestinal)
TMEM2 transmembrane protein 2
TMPRSS3 transmembrane protease, serine 3

decreased expression

Symbol Name
AUTS2 autism susceptibility candidate 2
CLIC4 chloride intracellular channel 4
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
GPM6B glycoprotein M6B
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
PDGFA platelet-derived growth factor alpha polypeptide
PXDN peroxidasin
RPP38 ribonuclease P/MRP 38kDa subunit
RPS4Y1 ribosomal protein S4, Y-linked 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10