BRD-K02708799_GSK-1059615_SKBR3_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

67 genes differentially expressed following the BRD-K02708799_GSK-1059615_SKBR3_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK AHNAK nucleoprotein
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
CCL5 chemokine (C-C motif) ligand 5
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2BK histone cluster 1, H2bk
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
KAT6B K(lysine) acetyltransferase 6B
KDM3A lysine (K)-specific demethylase 3A
LGALS1 lectin, galactoside-binding, soluble, 1
LUC7L3 LUC7-like 3 (S. cerevisiae)
MELK maternal embryonic leucine zipper kinase
METTL7A methyltransferase like 7A
OPN3 opsin 3
PEG3 paternally expressed 3
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PSAP prosaposin
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SYNM synemin, intermediate filament protein
TXNIP thioredoxin interacting protein

decreased expression

Symbol Name
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
C3 complement component 3
CASP2 caspase 2, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CCND2 cyclin D2
CD24 CD24 molecule
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHGB chromogranin B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CP ceruloplasmin (ferroxidase)
CTSZ cathepsin Z
CXCL14 chemokine (C-X-C motif) ligand 14
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF4E eukaryotic translation initiation factor 4E
FHL2 four and a half LIM domains 2
FLRT3 fibronectin leucine rich transmembrane protein 3
FOXC1 forkhead box C1
G0S2 G0/G1 switch 2
GJA1 gap junction protein, alpha 1, 43kDa
HIGD1A HIG1 hypoxia inducible domain family, member 1A
KRT19 keratin 19, type I
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
NNMT nicotinamide N-methyltransferase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A
RBP4 retinol binding protein 4, plasma
SDC4 syndecan 4
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
TF transferrin
TFPI2 tissue factor pathway inhibitor 2
TUBA4A tubulin, alpha 4a
TXNDC9 thioredoxin domain containing 9
VCAM1 vascular cell adhesion molecule 1
ZBTB18 zinc finger and BTB domain containing 18