BRD-K02708799_GSK-1059615_MCF7_3_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

183 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF7_3_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ADRB2 adrenoceptor beta 2, surface
AHR aryl hydrocarbon receptor
ALCAM activated leukocyte cell adhesion molecule
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ATF3 activating transcription factor 3
BST2 bone marrow stromal cell antigen 2
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CCR7 chemokine (C-C motif) receptor 7
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHN1 chimerin 1
CLDN3 claudin 3
COCH cochlin
CPE carboxypeptidase E
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DHRS2 dehydrogenase/reductase (SDR family) member 2
DLK1 delta-like 1 homolog (Drosophila)
DPP4 dipeptidyl-peptidase 4
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FST follistatin
FZD7 frizzled class receptor 7
GAS1 growth arrest-specific 1
GNLY granulysin
GREM1 gremlin 1, DAN family BMP antagonist
GZMK granzyme K (granzyme 3; tryptase II)
H1F0 H1 histone family, member 0
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BD histone cluster 1, H2bd
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFIH1 interferon induced with helicase C domain 1
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
IFITM1 interferon induced transmembrane protein 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGHM immunoglobulin heavy constant mu
IL7R interleukin 7 receptor
IRF7 interferon regulatory factor 7
ISG15 ISG15 ubiquitin-like modifier
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIAA0430 KIAA0430
KIAA1598
KIF14 kinesin family member 14
KIF20A kinesin family member 20A
KYNU kynureninase
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
MAGEA3 melanoma antigen family A3
MAP7 microtubule-associated protein 7
MATN2 matrilin 2
METTL7A methyltransferase like 7A
MT1E metallothionein 1E
MTUS1 microtubule associated tumor suppressor 1
MYOF myoferlin
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NKG7 natural killer cell granule protein 7
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PAN2 PAN2 poly(A) specific ribonuclease subunit
PARP8 poly (ADP-ribose) polymerase family, member 8
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PRKCH protein kinase C, eta
PSD3 pleckstrin and Sec7 domain containing 3
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTPN6 protein tyrosine phosphatase, non-receptor type 6
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RHOBTB3 Rho-related BTB domain containing 3
RSRP1 arginine/serine-rich protein 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOD2 superoxide dismutase 2, mitochondrial
SORD sorbitol dehydrogenase
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
STAT1 signal transducer and activator of transcription 1, 91kDa
TARP TCR gamma alternate reading frame protein
TBX3 T-box 3
TGFB1 transforming growth factor, beta 1
TIMP1 TIMP metallopeptidase inhibitor 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TMEM176B transmembrane protein 176B
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4
TNS3 tensin 3
TOMM34 translocase of outer mitochondrial membrane 34
TSC22D1 TSC22 domain family, member 1
TWIST1 twist family bHLH transcription factor 1
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VNN1 vanin 1
WIPF2 WAS/WASL interacting protein family, member 2
XCL1 chemokine (C motif) ligand 1
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
ZNF217 zinc finger protein 217

decreased expression

Symbol Name
ACTA2 actin, alpha 2, smooth muscle, aorta
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BEX1 brain expressed, X-linked 1
BIN1 bridging integrator 1
CD36 CD36 molecule (thrombospondin receptor)
CD59 CD59 molecule, complement regulatory protein
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHMP6 charged multivesicular body protein 6
CLC Charcot-Leyden crystal galectin
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle)
CRYAB crystallin, alpha B
CTSC cathepsin C
CX3CL1 chemokine (C-X3-C motif) ligand 1
CXCL5 chemokine (C-X-C motif) ligand 5
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DCBLD2 discoidin, CUB and LCCL domain containing 2
DEFB1 defensin, beta 1
EGR2 early growth response 2
ELANE elastase, neutrophil expressed
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
G0S2 G0/G1 switch 2
GEM GTP binding protein overexpressed in skeletal muscle
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPX3 glutathione peroxidase 3
HMGA2 high mobility group AT-hook 2
HOPX HOP homeobox
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
IFRD2 interferon-related developmental regulator 2
IL1RN interleukin 1 receptor antagonist
INSIG1 insulin induced gene 1
JAG1 jagged 1
JMJD6 jumonji domain containing 6
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLF10 Kruppel-like factor 10
KRT14 keratin 14, type I
LMO4 LIM domain only 4
LYPLA1 lysophospholipase I
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP3 matrix metallopeptidase 3
MYLK myosin light chain kinase
NCK1 NCK adaptor protein 1
NR2F6 nuclear receptor subfamily 2, group F, member 6
NRN1 neuritin 1
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
POSTN periostin, osteoblast specific factor
RNASE3 ribonuclease, RNase A family, 3
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A8 S100 calcium binding protein A8
S100P S100 calcium binding protein P
SIK1 salt-inducible kinase 1
SLC16A4 solute carrier family 16, member 4
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SLPI secretory leukocyte peptidase inhibitor
SNAP25 synaptosomal-associated protein, 25kDa
SOX9 SRY (sex determining region Y)-box 9
SPP1 secreted phosphoprotein 1
SRGN serglycin
TARBP1 TAR (HIV-1) RNA binding protein 1
TEX10 testis expressed 10
TFF3 trefoil factor 3 (intestinal)
TIMP4 TIMP metallopeptidase inhibitor 4
TM4SF1 transmembrane 4 L six family member 1
TUBA1A tubulin, alpha 1a
UTP14A UTP14, U3 small nucleolar ribonucleoprotein, homolog A (yeast)
WFDC2 WAP four-disulfide core domain 2
ZMYM2 zinc finger, MYM-type 2