BRD-K02708799_GSK-1059615_MCF7_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF7_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AGR2 anterior gradient 2
ALDOA aldolase A, fructose-bisphosphate
AMIGO2 adhesion molecule with Ig-like domain 2
AQP3 aquaporin 3 (Gill blood group)
ATP6V0E1 ATPase, H+ transporting, lysosomal 9kDa, V0 subunit e1
BTG2 BTG family, member 2
C2CD5 C2 calcium-dependent domain containing 5
CCNG2 cyclin G2
CD9 CD9 molecule
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CLC Charcot-Leyden crystal galectin
COPS7A COP9 signalosome subunit 7A
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DCN decorin
DPYSL2 dihydropyrimidinase-like 2
DSP desmoplakin
EMP1 epithelial membrane protein 1
EPHB2 EPH receptor B2
ERBB3 erb-b2 receptor tyrosine kinase 3
EXPH5 exophilin 5
FBXO21 F-box protein 21
FGFR2 fibroblast growth factor receptor 2
GREM1 gremlin 1, DAN family BMP antagonist
H2AFY H2A histone family, member Y
HNMT histamine N-methyltransferase
HSPA2 heat shock 70kDa protein 2
IGFBP7 insulin-like growth factor binding protein 7
KRT18 keratin 18, type I
KRT19 keratin 19, type I
LDHB lactate dehydrogenase B
LGALS3 lectin, galactoside-binding, soluble, 3
LUM lumican
MAL mal, T-cell differentiation protein
MAPT microtubule-associated protein tau
MEF2C myocyte enhancer factor 2C
MGLL monoglyceride lipase
MMP7 matrix metallopeptidase 7
MXI1 MAX interactor 1, dimerization protein
MYBPC1 myosin binding protein C, slow type
MYC v-myc avian myelocytomatosis viral oncogene homolog
MYO6 myosin VI
NBR1 neighbor of BRCA1 gene 1
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDZK1IP1 PDZK1 interacting protein 1
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PMP22 peripheral myelin protein 22
PNRC1 proline-rich nuclear receptor coactivator 1
PPARG peroxisome proliferator-activated receptor gamma
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPL periplakin
PRSS2 protease, serine, 2 (trypsin 2)
PTER phosphotriesterase related
QPCT glutaminyl-peptide cyclotransferase
RBM47 RNA binding motif protein 47
RNF130 ring finger protein 130
RPL38 ribosomal protein L38
S100P S100 calcium binding protein P
SATB2 SATB homeobox 2
SCUBE2 signal peptide, CUB domain, EGF-like 2
SH3YL1 SH3 and SYLF domain containing 1
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SMAD3 SMAD family member 3
SRI sorcin
SRPX sushi-repeat containing protein, X-linked
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TP53 tumor protein p53
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TRIM8 tripartite motif containing 8
TSPAN12 tetraspanin 12
TXNIP thioredoxin interacting protein
VCAM1 vascular cell adhesion molecule 1

decreased expression

Symbol Name
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AHSG alpha-2-HS-glycoprotein
AK1 adenylate kinase 1
APOA2 apolipoprotein A-II
APOE apolipoprotein E
ASCL1 achaete-scute family bHLH transcription factor 1
BAG2 BCL2-associated athanogene 2
C20ORF24 chromosome 20 open reading frame 24
C3AR1 complement component 3a receptor 1
C7 complement component 7
CA12 carbonic anhydrase XII
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene)
CD24 CD24 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COL4A5 collagen, type IV, alpha 5
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CRABP1 cellular retinoic acid binding protein 1
CREG1 cellular repressor of E1A-stimulated genes 1
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLK1 delta-like 1 homolog (Drosophila)
EFNB2 ephrin-B2
ENG endoglin
EPHA3 EPH receptor A3
FLRT3 fibronectin leucine rich transmembrane protein 3
G0S2 G0/G1 switch 2
GBP1 guanylate binding protein 1, interferon-inducible
GCH1 GTP cyclohydrolase 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
IKZF1 IKAROS family zinc finger 1 (Ikaros)
JMJD6 jumonji domain containing 6
KRT15 keratin 15, type I
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
NQO1 NAD(P)H dehydrogenase, quinone 1
NVL nuclear VCP-like
ODC1 ornithine decarboxylase 1
OXA1L oxidase (cytochrome c) assembly 1-like
PEG10 paternally expressed 10
PLN phospholamban
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PRR16 proline rich 16
PRSS8 protease, serine, 8
PSMB5 proteasome (prosome, macropain) subunit, beta type, 5
PTN pleiotrophin
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
TBX2 T-box 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFRC transferrin receptor
TIGAR TP53 induced glycolysis regulatory phosphatase
TLR4 toll-like receptor 4
TMEM70 transmembrane protein 70
VWA1 von Willebrand factor A domain containing 1
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
ZNF395 zinc finger protein 395