BRD-K02708799_GSK-1059615_MCF10A_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

308 genes differentially expressed following the BRD-K02708799_GSK-1059615_MCF10A_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ACKR3 atypical chemokine receptor 3
ADGRG2 adhesion G protein-coupled receptor G2
ADIRF adipogenesis regulatory factor
AHNAK AHNAK nucleoprotein
AHNAK2 AHNAK nucleoprotein 2
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDH7A1 aldehyde dehydrogenase 7 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ANXA4 annexin A4
APOA1 apolipoprotein A-I
APOD apolipoprotein D
ARMCX1 armadillo repeat containing, X-linked 1
BCL6 B-cell CLL/lymphoma 6
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C1RL complement component 1, r subcomponent-like
C1S complement component 1, s subcomponent
CAV1 caveolin 1, caveolae protein, 22kDa
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CD302 CD302 molecule
CD44 CD44 molecule (Indian blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CD99 CD99 molecule
CDK19 cyclin-dependent kinase 19
CECR1 cat eye syndrome chromosome region, candidate 1
CFD complement factor D (adipsin)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHRDL1 chordin-like 1
COL18A1 collagen, type XVIII, alpha 1
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
CRIP1 cysteine-rich protein 1 (intestinal)
CRYAB crystallin, alpha B
CTSD cathepsin D
CYFIP2 cytoplasmic FMR1 interacting protein 2
CYTH1 cytohesin 1
DIAPH2 diaphanous-related formin 2
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYD dihydropyrimidine dehydrogenase
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
DRAM1 DNA-damage regulated autophagy modulator 1
DUSP22 dual specificity phosphatase 22
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EGFR epidermal growth factor receptor
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FADS3 fatty acid desaturase 3
FAM134A family with sequence similarity 134, member A
FAXDC2 fatty acid hydroxylase domain containing 2
FBN1 fibrillin 1
FGG fibrinogen gamma chain
FN1 fibronectin 1
FOXN3 forkhead box N3
FTH1 ferritin, heavy polypeptide 1
GAA glucosidase, alpha; acid
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GFOD1 glucose-fructose oxidoreductase domain containing 1
GLTSCR2 glioma tumor suppressor candidate region gene 2
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GSN gelsolin
H3F3B H3 histone, family 3B (H3.3B)
HBP1 HMG-box transcription factor 1
HDAC6 histone deacetylase 6
HIST1H1C histone cluster 1, H1c
HLA-E major histocompatibility complex, class I, E
ICAM3 intercellular adhesion molecule 3
IDS iduronate 2-sulfatase
IFITM1 interferon induced transmembrane protein 1
INHBA inhibin, beta A
IRF9 interferon regulatory factor 9
ITGB4 integrin, beta 4
ITGB5 integrin, beta 5
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KRT15 keratin 15, type I
LAMP2 lysosomal-associated membrane protein 2
LDOC1 leucine zipper, down-regulated in cancer 1
LIMS1 LIM and senescent cell antigen-like domains 1
LOX lysyl oxidase
LTBP1 latent transforming growth factor beta binding protein 1
LXN latexin
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
METTL7A methyltransferase like 7A
MTSS1 metastasis suppressor 1
MYO5C myosin VC
NACC2 NACC family member 2, BEN and BTB (POZ) domain containing
NARF nuclear prelamin A recognition factor
NARFL nuclear prelamin A recognition factor-like
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NNMT nicotinamide N-methyltransferase
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
NPEPL1 aminopeptidase-like 1
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PEX11A peroxisomal biogenesis factor 11 alpha
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PNRC1 proline-rich nuclear receptor coactivator 1
PPL periplakin
PROM1 prominin 1
PRUNE2 prune homolog 2 (Drosophila)
PSIP1 PC4 and SFRS1 interacting protein 1
PTPN13 protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
PXDN peroxidasin
RABAC1 Rab acceptor 1 (prenylated)
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
REEP1 receptor accessory protein 1
RSRP1 arginine/serine-rich protein 1
SEPP1 selenoprotein P, plasma, 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SEZ6L2 seizure related 6 homolog (mouse)-like 2
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SKAP2 src kinase associated phosphoprotein 2
SLC14A1 solute carrier family 14 (urea transporter), member 1 (Kidd blood group)
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC22A4 solute carrier family 22 (organic cation/zwitterion transporter), member 4
SLC35E2B solute carrier family 35, member E2B
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SOD2 superoxide dismutase 2, mitochondrial
SOX4 SRY (sex determining region Y)-box 4
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor)
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
STON1 stonin 1
SULF1 sulfatase 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
SYNE2 spectrin repeat containing, nuclear envelope 2
SYT17 synaptotagmin XVII
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TCEAL4 transcription elongation factor A (SII)-like 4
TCTA T-cell leukemia translocation altered
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
THBS3 thrombospondin 3
TLR4 toll-like receptor 4
TMSB15A thymosin beta 15a
TMSB15B thymosin beta 15B
TP53I3 tumor protein p53 inducible protein 3
TPM2 tropomyosin 2 (beta)
TPP1 tripeptidyl peptidase I
TRAM2 translocation associated membrane protein 2
TRIM22 tripartite motif containing 22
TSC22D3 TSC22 domain family, member 3
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
USP9X ubiquitin specific peptidase 9, X-linked
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
WDR13 WD repeat domain 13
WDR45 WD repeat domain 45
YPEL5 yippee-like 5 (Drosophila)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ABAT 4-aminobutyrate aminotransferase
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1
AK1 adenylate kinase 1
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANP32E acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
ATF5 activating transcription factor 5
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BAG2 BCL2-associated athanogene 2
BCHE butyrylcholinesterase
BCL2A1 BCL2-related protein A1
BLMH bleomycin hydrolase
CACYBP calcyclin binding protein
CADM1 cell adhesion molecule 1
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CD24 CD24 molecule
CD320 CD320 molecule
CDC25A cell division cycle 25A
CDC6 cell division cycle 6
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN3 cyclin-dependent kinase inhibitor 3
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHD7 chromodomain helicase DNA binding protein 7
CRCT1 cysteine-rich C-terminal 1
CSE1L CSE1 chromosome segregation 1-like (yeast)
CTSG cathepsin G
CX3CR1 chemokine (C-X3-C motif) receptor 1
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
CYCS cytochrome c, somatic
DBF4 DBF4 zinc finger
DLD dihydrolipoamide dehydrogenase
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
ECI2 enoyl-CoA delta isomerase 2
EIF4E eukaryotic translation initiation factor 4E
EXO1 exonuclease 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM162A family with sequence similarity 162, member A
FEN1 flap structure-specific endonuclease 1
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FSCN1 fascin actin-bundling protein 1
GAL galanin/GMAP prepropeptide
GATAD2A GATA zinc finger domain containing 2A
GINS2 GINS complex subunit 2 (Psf2 homolog)
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HMGB1 high mobility group box 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IER3 immediate early response 3
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IL1B interleukin 1, beta
IL1RN interleukin 1 receptor antagonist
KIAA0226L KIAA0226-like
KRT14 keratin 14, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LARP4 La ribonucleoprotein domain family, member 4
LBR lamin B receptor
LEF1 lymphoid enhancer-binding factor 1
LRRC59 leucine rich repeat containing 59
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
LTF lactotransferrin
MAK16 MAK16 homolog (S. cerevisiae)
MCM10 minichromosome maintenance complex component 10
MCM4 minichromosome maintenance complex component 4
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MMP9 matrix metallopeptidase 9
MOCS2 molybdenum cofactor synthesis 2
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYCBP MYC binding protein
NAV3 neuron navigator 3
NDUFAF4 NADH dehydrogenase (ubiquinone) complex I, assembly factor 4
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NOP56 NOP56 ribonucleoprotein
NUPL1 nucleoporin like 1
ODC1 ornithine decarboxylase 1
PARP2 poly (ADP-ribose) polymerase 2
PCNA proliferating cell nuclear antigen
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAC8 placenta-specific 8
PLS1 plastin 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLR3G polymerase (RNA) III (DNA directed) polypeptide G (32kD)
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa
PPIF peptidylprolyl isomerase F
PRSS3 protease, serine, 3
PSAT1 phosphoserine aminotransferase 1
QDPR quinoid dihydropteridine reductase
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RPIA ribose 5-phosphate isomerase A
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCML1 sex comb on midleg-like 1 (Drosophila)
SEC23B Sec23 homolog B (S. cerevisiae)
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SHCBP1 SHC SH2-domain binding protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC43A3 solute carrier family 43, member 3
SLIRP SRA stem-loop interacting RNA binding protein
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPG small nuclear ribonucleoprotein polypeptide G
SORD sorbitol dehydrogenase
SPAG1 sperm associated antigen 1
SPATS2L spermatogenesis associated, serine-rich 2-like
SRM spermidine synthase
SUB1 SUB1 homolog (S. cerevisiae)
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF3 trefoil factor 3 (intestinal)
TIPIN TIMELESS interacting protein
TMX2 thioredoxin-related transmembrane protein 2
TPD52 tumor protein D52
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
UBE2S ubiquitin-conjugating enzyme E2S
UCHL3 ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
VRK1 vaccinia related kinase 1
WARS tryptophanyl-tRNA synthetase
ZBTB18 zinc finger and BTB domain containing 18