BRD-K02708799_GSK-1059615_HT29_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

344 genes differentially expressed following the BRD-K02708799_GSK-1059615_HT29_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABLIM1 actin binding LIM protein 1
ACKR3 atypical chemokine receptor 3
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AHR aryl hydrocarbon receptor
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
ANXA4 annexin A4
ARMCX1 armadillo repeat containing, X-linked 1
ASS1 argininosuccinate synthase 1
ATP9A ATPase, class II, type 9A
AZU1 azurocidin 1
BEX1 brain expressed, X-linked 1
BIK BCL2-interacting killer (apoptosis-inducing)
BST2 bone marrow stromal cell antigen 2
BTG1 B-cell translocation gene 1, anti-proliferative
BTN3A2 butyrophilin, subfamily 3, member A2
C10ORF10 chromosome 10 open reading frame 10
C14ORF132 chromosome 14 open reading frame 132
C1ORF106 chromosome 1 open reading frame 106
C2CD5 C2 calcium-dependent domain containing 5
CAST calpastatin
CCDC92 coiled-coil domain containing 92
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD93 CD93 molecule
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEP68 centrosomal protein 68kDa
CFB complement factor B
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLEC11A C-type lectin domain family 11, member A
CNOT2 CCR4-NOT transcription complex, subunit 2
CP ceruloplasmin (ferroxidase)
CTSA cathepsin A
CTSG cathepsin G
CYBA cytochrome b-245, alpha polypeptide
DAPK1 death-associated protein kinase 1
DCLK1 doublecortin-like kinase 1
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DEFB1 defensin, beta 1
DLK1 delta-like 1 homolog (Drosophila)
DMXL2 Dmx-like 2
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DNM1L dynamin 1-like
DPYSL2 dihydropyrimidinase-like 2
EDN1 endothelin 1
EFNA1 ephrin-A1
EFNB2 ephrin-B2
ENO2 enolase 2 (gamma, neuronal)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
F13A1 coagulation factor XIII, A1 polypeptide
FAM134A family with sequence similarity 134, member A
FAM63A family with sequence similarity 63, member A
FCGBP Fc fragment of IgG binding protein
FGFR2 fibroblast growth factor receptor 2
FOXO4 forkhead box O4
GAS1 growth arrest-specific 1
GAS2 growth arrest-specific 2
GAS6 growth arrest-specific 6
GLTSCR2 glioma tumor suppressor candidate region gene 2
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GOLGA8H golgin A8 family, member H
GPNMB glycoprotein (transmembrane) nmb
GRAMD3 GRAM domain containing 3
GSN gelsolin
GSTT1 glutathione S-transferase theta 1
H3F3B H3 histone, family 3B (H3.3B)
HDAC6 histone deacetylase 6
HEPH hephaestin
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
HLA-B major histocompatibility complex, class I, B
HLA-E major histocompatibility complex, class I, E
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HOOK2 hook microtubule-tethering protein 2
HOXA5 homeobox A5
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
IFI44L interferon-induced protein 44-like
IFI6 interferon, alpha-inducible protein 6
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IGBP1 immunoglobulin (CD79A) binding protein 1
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
IGKC immunoglobulin kappa constant
IGKV1-5 immunoglobulin kappa variable 1-5
IGLJ3 immunoglobulin lambda joining 3
INA internexin neuronal intermediate filament protein, alpha
INSR insulin receptor
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
ITM2C integral membrane protein 2C
JUP junction plakoglobin
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KLF5 Kruppel-like factor 5 (intestinal)
KRT19 keratin 19, type I
KRT7 keratin 7, type II
LCN2 lipocalin 2
LGALS3 lectin, galactoside-binding, soluble, 3
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOC100505650 uncharacterized LOC100505650
LYZ lysozyme
MAOA monoamine oxidase A
MARCKSL1 MARCKS-like 1
MFAP5 microfibrillar associated protein 5
MGP matrix Gla protein
MMP7 matrix metallopeptidase 7
MTSS1 metastasis suppressor 1
MTUS1 microtubule associated tumor suppressor 1
MVP major vault protein
MX1 MX dynamin-like GTPase 1
MX2 MX dynamin-like GTPase 2
MXI1 MAX interactor 1, dimerization protein
MYH14 myosin, heavy chain 14, non-muscle
NDRG1 N-myc downstream regulated 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NFIB nuclear factor I/B
NID1 nidogen 1
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NPTX2 neuronal pentraxin II
NR2F2 nuclear receptor subfamily 2, group F, member 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUPR1 nuclear protein, transcriptional regulator, 1
ORAI3 ORAI calcium release-activated calcium modulator 3
PAN2 PAN2 poly(A) specific ribonuclease subunit
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBLD phenazine biosynthesis-like protein domain containing
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDZK1IP1 PDZK1 interacting protein 1
PEG3 paternally expressed 3
PELI2 pellino E3 ubiquitin protein ligase family member 2
PHYH phytanoyl-CoA 2-hydroxylase
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLAC8 placenta-specific 8
PLCB4 phospholipase C, beta 4
PLXND1 plexin D1
PNMA2 paraneoplastic Ma antigen 2
PPIC peptidylprolyl isomerase C (cyclophilin C)
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTEN phosphatase and tensin homolog
PTPRK protein tyrosine phosphatase, receptor type, K
QPCT glutaminyl-peptide cyclotransferase
RAB13 RAB13, member RAS oncogene family
RAB29 RAB29, member RAS oncogene family
RAB4A RAB4A, member RAS oncogene family
RABAC1 Rab acceptor 1 (prenylated)
RAP1GAP RAP1 GTPase activating protein
RBM6 RNA binding motif protein 6
REG1A regenerating islet-derived 1 alpha
RGS5 regulator of G-protein signaling 5
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RNASET2 ribonuclease T2
RPL31 ribosomal protein L31
RSRP1 arginine/serine-rich protein 1
S100P S100 calcium binding protein P
SCAND1 SCAN domain containing 1
SELE selectin E
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SIDT2 SID1 transmembrane family, member 2
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC35E2B solute carrier family 35, member E2B
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SOX4 SRY (sex determining region Y)-box 4
SPATA20 spermatogenesis associated 20
SPINK1 serine peptidase inhibitor, Kazal type 1
SPINK4 serine peptidase inhibitor, Kazal type 4
SPINT1 serine peptidase inhibitor, Kunitz type 1
SPINT2 serine peptidase inhibitor, Kunitz type, 2
SSPN sarcospan
STAT1 signal transducer and activator of transcription 1, 91kDa
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
SYNE2 spectrin repeat containing, nuclear envelope 2
SYNM synemin, intermediate filament protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNS1 tensin 1
TOX thymocyte selection-associated high mobility group box
TPP1 tripeptidyl peptidase I
TRAPPC6A trafficking protein particle complex 6A
TRIM2 tripartite motif containing 2
TRPM4 transient receptor potential cation channel, subfamily M, member 4
TSPYL5 TSPY-like 5
TST thiosulfate sulfurtransferase (rhodanese)
TUBA1A tubulin, alpha 1a
TXNIP thioredoxin interacting protein
VGLL4 vestigial-like family member 4
VIM vimentin
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)

decreased expression

Symbol Name
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5
ACPP acid phosphatase, prostate
ACSL1 acyl-CoA synthetase long-chain family member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
AUTS2 autism susceptibility candidate 2
BASP1 brain abundant, membrane attached signal protein 1
BCAT1 branched chain amino-acid transaminase 1, cytosolic
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CADM1 cell adhesion molecule 1
CALM3 calmodulin 3 (phosphorylase kinase, delta)
CAV1 caveolin 1, caveolae protein, 22kDa
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCNA2 cyclin A2
CCND2 cyclin D2
CD36 CD36 molecule (thrombospondin receptor)
CD48 CD48 molecule
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CKS2 CDC28 protein kinase regulatory subunit 2
COL4A2 collagen, type IV, alpha 2
COL4A6 collagen, type IV, alpha 6
COL5A2 collagen, type V, alpha 2
CPB1 carboxypeptidase B1 (tissue)
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1
CTSC cathepsin C
CXCL12 chemokine (C-X-C motif) ligand 12
CYTL1 cytokine-like 1
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A
DLC1 DLC1 Rho GTPase activating protein
DNAJA3 DnaJ (Hsp40) homolog, subfamily A, member 3
DUSP2 dual specificity phosphatase 2
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
ENC1 ectodermal-neural cortex 1 (with BTB domain)
EREG epiregulin
F3 coagulation factor III (thromboplastin, tissue factor)
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FHL1 four and a half LIM domains 1
FOSL1 FOS-like antigen 1
FST follistatin
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GATA3 GATA binding protein 3
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLIPR1 GLI pathogenesis-related 1
GLRX2 glutaredoxin 2
GPM6B glycoprotein M6B
GPR171 G protein-coupled receptor 171
GPX3 glutathione peroxidase 3
GRWD1 glutamate-rich WD repeat containing 1
HBB hemoglobin, beta
HMGB2 high mobility group box 2
HOPX HOP homeobox
HOXB2 homeobox B2
IARS isoleucyl-tRNA synthetase
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
IDI1 isopentenyl-diphosphate delta isomerase 1
IFRD2 interferon-related developmental regulator 2
ISOC1 isochorismatase domain containing 1
KLHL7 kelch-like family member 7
KRT17 keratin 17, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LEF1 lymphoid enhancer-binding factor 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LPL lipoprotein lipase
LPXN leupaxin
LSM1 LSM1, U6 small nuclear RNA associated
LTF lactotransferrin
LYPLA1 lysophospholipase I
MAGEA3 melanoma antigen family A3
MMD monocyte to macrophage differentiation-associated
MSMB microseminoprotein, beta-
MUC16 mucin 16, cell surface associated
NAMPT nicotinamide phosphoribosyltransferase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NEK2 NIMA-related kinase 2
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NQO1 NAD(P)H dehydrogenase, quinone 1
NTS neurotensin
NXT1 nuclear transport factor 2-like export factor 1
ODC1 ornithine decarboxylase 1
PAK1IP1 PAK1 interacting protein 1
PCNA proliferating cell nuclear antigen
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM1 PDZ and LIM domain 1
PDZK1 PDZ domain containing 1
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
PNO1 partner of NOB1 homolog (S. cerevisiae)
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAT phosphoribosyl pyrophosphate amidotransferase
PRPF4 pre-mRNA processing factor 4
QDPR quinoid dihydropteridine reductase
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RFC3 replication factor C (activator 1) 3, 38kDa
RGS1 regulator of G-protein signaling 1
RRP15 ribosomal RNA processing 15 homolog (S. cerevisiae)
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCARB2 scavenger receptor class B, member 2
SCEL sciellin
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SIK1 salt-inducible kinase 1
SLC35F2 solute carrier family 35, member F2
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNRPG small nuclear ribonucleoprotein polypeptide G
SRM spermidine synthase
SSBP2 single-stranded DNA binding protein 2
STC1 stanniocalcin 1
STK17A serine/threonine kinase 17a
STXBP6 syntaxin binding protein 6 (amisyn)
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM70 transmembrane protein 70
TPM4 tropomyosin 4
TUBB2A tubulin, beta 2A class IIa
TUSC3 tumor suppressor candidate 3
TWF1 twinfilin actin binding protein 1
UBE2S ubiquitin-conjugating enzyme E2S
UPK1B uroplakin 1B
VDAC1 voltage-dependent anion channel 1
WDR1 WD repeat domain 1