BRD-K02708799_GSK-1059615_HEPG2_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

343 genes differentially expressed following the BRD-K02708799_GSK-1059615_HEPG2_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIPOQ adiponectin, C1Q and collagen domain containing
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AGTR1 angiotensin II receptor, type 1
AHR aryl hydrocarbon receptor
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOB aldolase B, fructose-bisphosphate
ANG angiogenin, ribonuclease, RNase A family, 5
ANPEP alanyl (membrane) aminopeptidase
AOX1 aldehyde oxidase 1
APOM apolipoprotein M
ARID4B AT rich interactive domain 4B (RBP1-like)
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2
ASPN asporin
ATP9A ATPase, class II, type 9A
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BAG6 BCL2-associated athanogene 6
BASP1 brain abundant, membrane attached signal protein 1
BCAM basal cell adhesion molecule (Lutheran blood group)
BCL6 B-cell CLL/lymphoma 6
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BEX4 brain expressed, X-linked 4
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
C1ORF115 chromosome 1 open reading frame 115
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAMKK2 calcium/calmodulin-dependent protein kinase kinase 2, beta
CCNG2 cyclin G2
CD44 CD44 molecule (Indian blood group)
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDK14 cyclin-dependent kinase 14
CDK5RAP3 CDK5 regulatory subunit associated protein 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
COL11A1 collagen, type XI, alpha 1
COL18A1 collagen, type XVIII, alpha 1
COLEC12 collectin sub-family member 12
CP ceruloplasmin (ferroxidase)
CPD carboxypeptidase D
CRISP3 cysteine-rich secretory protein 3
CTGF connective tissue growth factor
CTSB cathepsin B
CUTA cutA divalent cation tolerance homolog (E. coli)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDAH2 dimethylarginine dimethylaminohydrolase 2
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DPYD dihydropyrimidine dehydrogenase
DUSP6 dual specificity phosphatase 6
EDN1 endothelin 1
EEF1D eukaryotic translation elongation factor 1 delta (guanine nucleotide exchange protein)
EHBP1 EH domain binding protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ERBB2 erb-b2 receptor tyrosine kinase 2
ERBB3 erb-b2 receptor tyrosine kinase 3
FCGBP Fc fragment of IgG binding protein
FCGRT Fc fragment of IgG, receptor, transporter, alpha
FGFR3 fibroblast growth factor receptor 3
FGG fibrinogen gamma chain
FOXN3 forkhead box N3
FOXO4 forkhead box O4
FXYD2 FXYD domain containing ion transport regulator 2
FZD2 frizzled class receptor 2
GAS1 growth arrest-specific 1
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GNS glucosamine (N-acetyl)-6-sulfatase
GPR137B G protein-coupled receptor 137B
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
H1F0 H1 histone family, member 0
HDAC6 histone deacetylase 6
HEG1 heart development protein with EGF-like domains 1
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER2 homer scaffolding protein 2
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP1 insulin-like growth factor binding protein 1
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2
IRS2 insulin receptor substrate 2
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITM2A integral membrane protein 2A
IVNS1ABP influenza virus NS1A binding protein
JMJD1C jumonji domain containing 1C
LCN2 lipocalin 2
LDOC1 leucine zipper, down-regulated in cancer 1
LEPR leptin receptor
LGALS8 lectin, galactoside-binding, soluble, 8
LMO2 LIM domain only 2 (rhombotin-like 1)
LOX lysyl oxidase
LY6E lymphocyte antigen 6 complex, locus E
MAGED2 melanoma antigen family D2
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
MARCKS myristoylated alanine-rich protein kinase C substrate
MARCKSL1 MARCKS-like 1
MDFIC MyoD family inhibitor domain containing
MET MET proto-oncogene, receptor tyrosine kinase
MFAP2 microfibrillar-associated protein 2
MGLL monoglyceride lipase
MPST mercaptopyruvate sulfurtransferase
MTMR11 myotubularin related protein 11
MUC5B mucin 5B, oligomeric mucus/gel-forming
MXI1 MAX interactor 1, dimerization protein
MXRA5 matrix-remodelling associated 5
MYH10 myosin, heavy chain 10, non-muscle
N4BP2L1 NEDD4 binding protein 2-like 1
NAV2 neuron navigator 2
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NR1D2 nuclear receptor subfamily 1, group D, member 2
NRIP1 nuclear receptor interacting protein 1
NTS neurotensin
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PBX1 pre-B-cell leukemia homeobox 1
PCGF2 polycomb group ring finger 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFC platelet derived growth factor C
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PDLIM5 PDZ and LIM domain 5
PDP1 pyruvate dehyrogenase phosphatase catalytic subunit 1
PDZK1IP1 PDZK1 interacting protein 1
PER1 period circadian clock 1
PEX11A peroxisomal biogenesis factor 11 alpha
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PIH1D1 PIH1 domain containing 1
PKP4 plakophilin 4
PLBD1 phospholipase B domain containing 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLS3 plastin 3
PLXNB2 plexin B2
PPAP2C phosphatidic acid phosphatase type 2C
PRKCA protein kinase C, alpha
PROS1 protein S (alpha)
PTGIS prostaglandin I2 (prostacyclin) synthase
PTN pleiotrophin
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
PXDN peroxidasin
PYGL phosphorylase, glycogen, liver
RAP2A RAP2A, member of RAS oncogene family
RBKS ribokinase
RNASE4 ribonuclease, RNase A family, 4
RPL36 ribosomal protein L36
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
SRRM2 serine/arginine repetitive matrix 2
STAR steroidogenic acute regulatory protein
STXBP2 syntaxin binding protein 2
TARBP1 TAR (HIV-1) RNA binding protein 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM4SF4 transmembrane 4 L six family member 4
TMC5 transmembrane channel-like 5
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TNNT1 troponin T type 1 (skeletal, slow)
TNS3 tensin 3
TPBG trophoblast glycoprotein
TRAF5 TNF receptor-associated factor 5
TRIB2 tribbles pseudokinase 2
TSC2 tuberous sclerosis 2
TSPAN13 tetraspanin 13
TSPAN8 tetraspanin 8
TUSC3 tumor suppressor candidate 3
TWF2 twinfilin actin binding protein 2
TXNIP thioredoxin interacting protein
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
VNN1 vanin 1
WDTC1 WD and tetratricopeptide repeats 1
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
XIST X inactive specific transcript (non-protein coding)
XYLT1 xylosyltransferase I
ZBTB38 zinc finger and BTB domain containing 38
ZEB2 zinc finger E-box binding homeobox 2
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
ADRB2 adrenoceptor beta 2, surface
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK1 adenylate kinase 1
ALOX5 arachidonate 5-lipoxygenase
APIP APAF1 interacting protein
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
ATF5 activating transcription factor 5
ATP5G1 ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
BAX BCL2-associated X protein
BLVRB biliverdin reductase B
BMP2 bone morphogenetic protein 2
C1ORF116 chromosome 1 open reading frame 116
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CADM1 cell adhesion molecule 1
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CCNA2 cyclin A2
CCND2 cyclin D2
CCNE2 cyclin E2
CCT2 chaperonin containing TCP1, subunit 2 (beta)
CD24 CD24 molecule
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL4A6 collagen, type IV, alpha 6
COL9A3 collagen, type IX, alpha 3
CORO1A coronin, actin binding protein, 1A
CRCT1 cysteine-rich C-terminal 1
CSTA cystatin A (stefin A)
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DHRS2 dehydrogenase/reductase (SDR family) member 2
DSC2 desmocollin 2
DSG3 desmoglein 3
ECM1 extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa
EIF3J eukaryotic translation initiation factor 3, subunit J
EIF5A eukaryotic translation initiation factor 5A
ELANE elastase, neutrophil expressed
ELN elastin
EREG epiregulin
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FGF13 fibroblast growth factor 13
FGFBP1 fibroblast growth factor binding protein 1
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
GATA3 GATA binding protein 3
GDE1 glycerophosphodiester phosphodiesterase 1
GRWD1 glutamate-rich WD repeat containing 1
GTF2A2 general transcription factor IIA, 2, 12kDa
HIGD1A HIG1 hypoxia inducible domain family, member 1A
HILPDA hypoxia inducible lipid droplet-associated
HIRA histone cell cycle regulator
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HOPX HOP homeobox
HSPA14 heat shock 70kDa protein 14
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HSPB8 heat shock 22kDa protein 8
IDH3A isocitrate dehydrogenase 3 (NAD+) alpha
IDI1 isopentenyl-diphosphate delta isomerase 1
IGHM immunoglobulin heavy constant mu
IGKV1-5 immunoglobulin kappa variable 1-5
IGKV4-1 immunoglobulin kappa variable 4-1
INSIG1 insulin induced gene 1
JCHAIN joining chain of multimeric IgA and IgM
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
LIPG lipase, endothelial
LOXL1 lysyl oxidase-like 1
LTB lymphotoxin beta (TNF superfamily, member 3)
LTF lactotransferrin
LY6D lymphocyte antigen 6 complex, locus D
LYZ lysozyme
MAL mal, T-cell differentiation protein
MAPK13 mitogen-activated protein kinase 13
MAPT microtubule-associated protein tau
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MINA MYC induced nuclear antigen
MLEC malectin
MPZL2 myelin protein zero-like 2
MRPL19 mitochondrial ribosomal protein L19
NKX3-1 NK3 homeobox 1
NMB neuromedin B
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
ODC1 ornithine decarboxylase 1
P2RY14 purinergic receptor P2Y, G-protein coupled, 14
PBK PDZ binding kinase
PDHX pyruvate dehydrogenase complex, component X
PGAM1 phosphoglycerate mutase 1 (brain)
PGC progastricsin (pepsinogen C)
PHLDA2 pleckstrin homology-like domain, family A, member 2
PNO1 partner of NOB1 homolog (S. cerevisiae)
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POLG2 polymerase (DNA directed), gamma 2, accessory subunit
PRKCH protein kinase C, eta
PRPF4 pre-mRNA processing factor 4
PTHLH parathyroid hormone-like hormone
RAD23B RAD23 homolog B (S. cerevisiae)
RAD51C RAD51 paralog C
RHCG Rh family, C glycoprotein
RHOB ras homolog family member B
RPIA ribose 5-phosphate isomerase A
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
SC5D sterol-C5-desaturase
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDF2L1 stromal cell-derived factor 2-like 1
SELT selenoprotein T
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SFTPB surfactant protein B
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLPI secretory leukocyte peptidase inhibitor
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPINK5 serine peptidase inhibitor, Kazal type 5
SPP1 secreted phosphoprotein 1
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
SPRR1A small proline-rich protein 1A
SPRR1B small proline-rich protein 1B
SPRR2B small proline-rich protein 2B
SPRR3 small proline-rich protein 3
SRGN serglycin
STAT1 signal transducer and activator of transcription 1, 91kDa
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
TFRC transferrin receptor
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNIP1 TNFAIP3 interacting protein 1
TUBB2A tubulin, beta 2A class IIa
UPP1 uridine phosphorylase 1
UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1