BRD-K02708799_GSK-1059615_HCC515_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

405 genes differentially expressed following the BRD-K02708799_GSK-1059615_HCC515_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AAMDC adipogenesis associated, Mth938 domain containing
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ABHD4 abhydrolase domain containing 4
ADAM10 ADAM metallopeptidase domain 10
ADAM28 ADAM metallopeptidase domain 28
ADGRF5 adhesion G protein-coupled receptor F5
AGR2 anterior gradient 2
AMIGO2 adhesion molecule with Ig-like domain 2
ANK3 ankyrin 3, node of Ranvier (ankyrin G)
APOBEC3G apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5
ASMTL acetylserotonin O-methyltransferase-like
ASPN asporin
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BEX1 brain expressed, X-linked 1
BGN biglycan
C1QA complement component 1, q subcomponent, A chain
C6ORF48 chromosome 6 open reading frame 48
C6ORF62 chromosome 6 open reading frame 62
CALCRL calcitonin receptor-like
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CCDC92 coiled-coil domain containing 92
CCL5 chemokine (C-C motif) ligand 5
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCNG2 cyclin G2
CCPG1 cell cycle progression 1
CD46 CD46 molecule, complement regulatory protein
CD99 CD99 molecule
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CDK19 cyclin-dependent kinase 19
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15
CLGN calmegin
COL11A1 collagen, type XI, alpha 1
COL1A1 collagen, type I, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL4A1 collagen, type IV, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPD carboxypeptidase D
CST1 cystatin SN
CTDSP2 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 2
CTGF connective tissue growth factor
CXCL13 chemokine (C-X-C motif) ligand 13
CYR61 cysteine-rich, angiogenic inducer, 61
DAXX death-domain associated protein
DDB2 damage-specific DNA binding protein 2, 48kDa
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DEFB1 defensin, beta 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
DYNLT3 dynein, light chain, Tctex-type 3
EAPP E2F-associated phosphoprotein
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGFL6 EGF-like-domain, multiple 6
EGR1 early growth response 1
EHD3 EH-domain containing 3
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1
EXOSC4 exosome component 4
F2R coagulation factor II (thrombin) receptor
FAM171A1 family with sequence similarity 171, member A1
FGG fibrinogen gamma chain
FLRT2 fibronectin leucine rich transmembrane protein 2
FMO3 flavin containing monooxygenase 3
FN1 fibronectin 1
FOXO4 forkhead box O4
GALC galactosylceramidase
GIMAP4 GTPase, IMAP family member 4
GMPR2 guanosine monophosphate reductase 2
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GREM1 gremlin 1, DAN family BMP antagonist
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HDAC6 histone deacetylase 6
HGSNAT heparan-alpha-glucosaminide N-acetyltransferase
HIST1H2AC histone cluster 1, H2ac
HIST1H2BD histone cluster 1, H2bd
HMG20B high mobility group 20B
HMOX1 heme oxygenase 1
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IDS iduronate 2-sulfatase
IFI6 interferon, alpha-inducible protein 6
IGBP1 immunoglobulin (CD79A) binding protein 1
IGFBP4 insulin-like growth factor binding protein 4
IL7R interleukin 7 receptor
INHBB inhibin, beta B
IRF9 interferon regulatory factor 9
IRS2 insulin receptor substrate 2
ITGAV integrin, alpha V
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KLF9 Kruppel-like factor 9
LAMP1 lysosomal-associated membrane protein 1
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LHFP lipoma HMGIC fusion partner
LINC00341 long intergenic non-protein coding RNA 341
LRMP lymphoid-restricted membrane protein
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MAGED1 melanoma antigen family D1
MAGED2 melanoma antigen family D2
MAPT microtubule-associated protein tau
MARCKS myristoylated alanine-rich protein kinase C substrate
METTL7A methyltransferase like 7A
MS4A1 membrane-spanning 4-domains, subfamily A, member 1
MTA1 metastasis associated 1
MXRA5 matrix-remodelling associated 5
NEBL nebulette
NEDD9 neural precursor cell expressed, developmentally down-regulated 9
NELL2 NEL-like 2 (chicken)
NID1 nidogen 1
NNMT nicotinamide N-methyltransferase
NPR3 natriuretic peptide receptor 3
NRGN neurogranin (protein kinase C substrate, RC3)
NUAK1 NUAK family, SNF1-like kinase, 1
OPN3 opsin 3
PAWR PRKC, apoptosis, WT1, regulator
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PDCD4 programmed cell death 4 (neoplastic transformation inhibitor)
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDZK1IP1 PDZK1 interacting protein 1
PGRMC2 progesterone receptor membrane component 2
PIGB phosphatidylinositol glycan anchor biosynthesis, class B
PIK3IP1 phosphoinositide-3-kinase interacting protein 1
PLIN2 perilipin 2
PLS3 plastin 3
PLXNB2 plexin B2
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
QPCT glutaminyl-peptide cyclotransferase
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RGS1 regulator of G-protein signaling 1
RPS4Y1 ribosomal protein S4, Y-linked 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SEPP1 selenoprotein P, plasma, 1
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SFTPA2 surfactant protein A2
SFTPB surfactant protein B
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
SH3BGRL SH3 domain binding glutamate-rich protein like
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SKAP2 src kinase associated phosphoprotein 2
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A2 solute carrier family 38, member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A7 solute carrier family 7 (amino acid transporter light chain, y+L system), member 7
SORBS2 sorbin and SH3 domain containing 2
STAT4 signal transducer and activator of transcription 4
SYT1 synaptotagmin I
SYT17 synaptotagmin XVII
TBC1D16 TBC1 domain family, member 16
TCEB2 transcription elongation factor B (SIII), polypeptide 2 (18kDa, elongin B)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TM7SF2 transmembrane 7 superfamily member 2
TMCO3 transmembrane and coiled-coil domains 3
TNS3 tensin 3
TP53I3 tumor protein p53 inducible protein 3
TPM1 tropomyosin 1 (alpha)
TPP1 tripeptidyl peptidase I
TSC22D3 TSC22 domain family, member 3
TSPAN13 tetraspanin 13
TXNL4B thioredoxin-like 4B
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
WDTC1 WD and tetratricopeptide repeats 1
YPEL5 yippee-like 5 (Drosophila)
ZMIZ1 zinc finger, MIZ-type containing 1
ZNF589 zinc finger protein 589
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABHD6 abhydrolase domain containing 6
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
ADGRL2 adhesion G protein-coupled receptor L2
ADRB2 adrenoceptor beta 2, surface
AEBP1 AE binding protein 1
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALOX5 arachidonate 5-lipoxygenase
AQP3 aquaporin 3 (Gill blood group)
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BACE2 beta-site APP-cleaving enzyme 2
BCAT1 branched chain amino-acid transaminase 1, cytosolic
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QBP complement component 1, q subcomponent binding protein
CA12 carbonic anhydrase XII
CALM1 calmodulin 1 (phosphorylase kinase, delta)
CALML5 calmodulin-like 5
CAPN2 calpain 2, (m/II) large subunit
CCL2 chemokine (C-C motif) ligand 2
CCL20 chemokine (C-C motif) ligand 20
CCND2 cyclin D2
CD47 CD47 molecule
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CDC42 cell division cycle 42
CDC6 cell division cycle 6
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CENPU centromere protein U
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CKS2 CDC28 protein kinase regulatory subunit 2
CLDN3 claudin 3
CLU clusterin
COL6A2 collagen, type VI, alpha 2
COL9A3 collagen, type IX, alpha 3
CPB1 carboxypeptidase B1 (tissue)
CSF2RB colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage)
CTSH cathepsin H
CTSZ cathepsin Z
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL8 chemokine (C-X-C motif) ligand 8
CYTL1 cytokine-like 1
DES desmin
DLD dihydrolipoamide dehydrogenase
DLK1 delta-like 1 homolog (Drosophila)
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DSCC1 DNA replication and sister chromatid cohesion 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUSP5 dual specificity phosphatase 5
EDNRB endothelin receptor type B
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF4A1 eukaryotic translation initiation factor 4A1
EIF5 eukaryotic translation initiation factor 5
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
EPHA3 EPH receptor A3
ESR1 estrogen receptor 1
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP1 fatty acid binding protein 1, liver
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FABP7 fatty acid binding protein 7, brain
FAM107A family with sequence similarity 107, member A
FAM162A family with sequence similarity 162, member A
FANCI Fanconi anemia, complementation group I
FANCL Fanconi anemia, complementation group L
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FGFBP1 fibroblast growth factor binding protein 1
FGFR3 fibroblast growth factor receptor 3
FOSL1 FOS-like antigen 1
FOXG1 forkhead box G1
FST follistatin
FXYD6 FXYD domain containing ion transport regulator 6
G0S2 G0/G1 switch 2
GALE UDP-galactose-4-epimerase
GATA6 GATA binding protein 6
GCH1 GTP cyclohydrolase 1
GEM GTP binding protein overexpressed in skeletal muscle
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GLDC glycine dehydrogenase (decarboxylating)
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GOLGA8A golgin A8 family, member A
GOLGA8B golgin A8 family, member B
GPC3 glypican 3
GPM6B glycoprotein M6B
GPRC5A G protein-coupled receptor, class C, group 5, member A
GYG1 glycogenin 1
HAL histidine ammonia-lyase
HBEGF heparin-binding EGF-like growth factor
HILPDA hypoxia inducible lipid droplet-associated
HIST1H2BG histone cluster 1, H2bg
HIST1H4C histone cluster 1, H4c
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPB8 heat shock 22kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
IFRD2 interferon-related developmental regulator 2
IGFBP1 insulin-like growth factor binding protein 1
IGFBP3 insulin-like growth factor binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
IL1RN interleukin 1 receptor antagonist
IL6R interleukin 6 receptor
INSIG1 insulin induced gene 1
KANK1 KN motif and ankyrin repeat domains 1
KCTD12 potassium channel tetramerization domain containing 12
KIAA0226L KIAA0226-like
KLF4 Kruppel-like factor 4 (gut)
KLK11 kallikrein-related peptidase 11
KLK5 kallikrein-related peptidase 5
KLK6 kallikrein-related peptidase 6
KRT15 keratin 15, type I
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIPG lipase, endothelial
LMO4 LIM domain only 4
LRRN3 leucine rich repeat neuronal 3
MALL mal, T-cell differentiation protein-like
MAPK13 mitogen-activated protein kinase 13
MATN2 matrilin 2
MBD2 methyl-CpG binding domain protein 2
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM4 minichromosome maintenance complex component 4
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MELK maternal embryonic leucine zipper kinase
MINA MYC induced nuclear antigen
MRPL12 mitochondrial ribosomal protein L12
MYH11 myosin, heavy chain 11, smooth muscle
NBL1 neuroblastoma 1, DAN family BMP antagonist
NFIB nuclear factor I/B
NOLC1 nucleolar and coiled-body phosphoprotein 1
NR1H2 nuclear receptor subfamily 1, group H, member 2
NRCAM neuronal cell adhesion molecule
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PCOLCE2 procollagen C-endopeptidase enhancer 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PGM1 phosphoglucomutase 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PIP prolactin-induced protein
PLA2G2A phospholipase A2, group IIA (platelets, synovial fluid)
PLAC8 placenta-specific 8
PLEKHJ1 pleckstrin homology domain containing, family J member 1
PLN phospholamban
PLP1 proteolipid protein 1
PLTP phospholipid transfer protein
PMP2 peripheral myelin protein 2
PMP22 peripheral myelin protein 22
PNMAL1 paraneoplastic Ma antigen family-like 1
PNP purine nucleoside phosphorylase
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPA1 pyrophosphatase (inorganic) 1
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPIF peptidylprolyl isomerase F
PROM1 prominin 1
PRSS3 protease, serine, 3
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PSPH phosphoserine phosphatase
PTGDS prostaglandin D2 synthase 21kDa (brain)
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1
QKI QKI, KH domain containing, RNA binding
RFC2 replication factor C (activator 1) 2, 40kDa
RGS2 regulator of G-protein signaling 2
RNF138 ring finger protein 138, E3 ubiquitin protein ligase
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1
RRAGD Ras-related GTP binding D
S100A10 S100 calcium binding protein A10
S100A9 S100 calcium binding protein A9
S100B S100 calcium binding protein B
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB2A2 secretoglobin, family 2A, member 2
SCRG1 stimulator of chondrogenesis 1
SERHL2 serine hydrolase-like 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC43A3 solute carrier family 43, member 3
SLCO4A1 solute carrier organic anion transporter family, member 4A1
SLN sarcolipin
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON1 spondin 1, extracellular matrix protein
SRI sorcin
STAR steroidogenic acute regulatory protein
STC1 stanniocalcin 1
STK26 serine/threonine protein kinase 26
SYCP2 synaptonemal complex protein 2
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
SYNM synemin, intermediate filament protein
TCL1A T-cell leukemia/lymphoma 1A
TEX10 testis expressed 10
TEX2 testis expressed 2
TFRC transferrin receptor
THBD thrombomodulin
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNC tenascin C
TOP2A topoisomerase (DNA) II alpha 170kDa
TPD52L1 tumor protein D52-like 1
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
TUBB6 tubulin, beta 6 class V
TUBG1 tubulin, gamma 1
TYMS thymidylate synthetase
TYRP1 tyrosinase-related protein 1
UGCG UDP-glucose ceramide glucosyltransferase
UNG uracil-DNA glycosylase
USP1 ubiquitin specific peptidase 1
VSIG4 V-set and immunoglobulin domain containing 4
WWTR1 WW domain containing transcription regulator 1
XIST X inactive specific transcript (non-protein coding)