BRD-K02708799_GSK-1059615_A549_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K02708799_GSK-1059615_A549_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AGR2 anterior gradient 2
AMOTL2 angiomotin like 2
ANXA4 annexin A4
APOD apolipoprotein D
ASPN asporin
B4GALT1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1
BSG basigin (Ok blood group)
BTG1 B-cell translocation gene 1, anti-proliferative
CA12 carbonic anhydrase XII
CAV1 caveolin 1, caveolae protein, 22kDa
CAV2 caveolin 2
CCL5 chemokine (C-C motif) ligand 5
CCNE2 cyclin E2
CCNG2 cyclin G2
CDK19 cyclin-dependent kinase 19
CES1 carboxylesterase 1
COL4A2 collagen, type IV, alpha 2
CRIP1 cysteine-rich protein 1 (intestinal)
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DUSP6 dual specificity phosphatase 6
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EIF5A eukaryotic translation initiation factor 5A
F2RL1 coagulation factor II (thrombin) receptor-like 1
FABP4 fatty acid binding protein 4, adipocyte
FBN1 fibrillin 1
GABARAPL1 GABA(A) receptor-associated protein like 1
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX4 glutathione peroxidase 4
GRN granulin
GSN gelsolin
HLA-E major histocompatibility complex, class I, E
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
HSPA2 heat shock 70kDa protein 2
IFI6 interferon, alpha-inducible protein 6
IGFBP7 insulin-like growth factor binding protein 7
IRS2 insulin receptor substrate 2
ISG15 ISG15 ubiquitin-like modifier
KAT6B K(lysine) acetyltransferase 6B
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KIAA1598
KRT8 keratin 8, type II
LDOC1 leucine zipper, down-regulated in cancer 1
LGALS8 lectin, galactoside-binding, soluble, 8
LINC00342 long intergenic non-protein coding RNA 342
LXN latexin
MARCKS myristoylated alanine-rich protein kinase C substrate
MBP myelin basic protein
MGLL monoglyceride lipase
MGP matrix Gla protein
MMD monocyte to macrophage differentiation-associated
MTUS1 microtubule associated tumor suppressor 1
MXRA7 matrix-remodelling associated 7
NAV2 neuron navigator 2
NGFRAP1 nerve growth factor receptor (TNFRSF16) associated protein 1
NT5E 5'-nucleotidase, ecto (CD73)
PGLS 6-phosphogluconolactonase
PLS3 plastin 3
POSTN periostin, osteoblast specific factor
RALGDS ral guanine nucleotide dissociation stimulator
RGS2 regulator of G-protein signaling 2
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3BGRL SH3 domain binding glutamate-rich protein like
SMAD3 SMAD family member 3
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SRGN serglycin
STC1 stanniocalcin 1
TCEA2 transcription elongation factor A (SII), 2
TFF1 trefoil factor 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TIAM1 T-cell lymphoma invasion and metastasis 1
TIMP1 TIMP metallopeptidase inhibitor 1
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAPPC6A trafficking protein particle complex 6A
TSPAN4 tetraspanin 4
UGDH UDP-glucose 6-dehydrogenase
ZFP36L1 ZFP36 ring finger protein-like 1
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ADRB2 adrenoceptor beta 2, surface
ALOX5 arachidonate 5-lipoxygenase
ARG2 arginase 2
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3
ASNS asparagine synthetase (glutamine-hydrolyzing)
BCAT1 branched chain amino-acid transaminase 1, cytosolic
CALML4 calmodulin-like 4
CDA cytidine deaminase
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTSZ cathepsin Z
CXCL8 chemokine (C-X-C motif) ligand 8
DENND1B DENN/MADD domain containing 1B
FKBP14 FK506 binding protein 14, 22 kDa
GAL galanin/GMAP prepropeptide
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GARS glycyl-tRNA synthetase
GFOD1 glucose-fructose oxidoreductase domain containing 1
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPER1 G protein-coupled estrogen receptor 1
GPM6B glycoprotein M6B
GREM1 gremlin 1, DAN family BMP antagonist
GRWD1 glutamate-rich WD repeat containing 1
GYG1 glycogenin 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
IARS isoleucyl-tRNA synthetase
IGFBP5 insulin-like growth factor binding protein 5
IL13RA2 interleukin 13 receptor, alpha 2
JMJD6 jumonji domain containing 6
KIAA0226L KIAA0226-like
KRT19 keratin 19, type I
LMO4 LIM domain only 4
MAPK13 mitogen-activated protein kinase 13
MNDA myeloid cell nuclear differentiation antigen
MSMB microseminoprotein, beta-
MYBPC1 myosin binding protein C, slow type
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PEA15 phosphoprotein enriched in astrocytes 15
PHGDH phosphoglycerate dehydrogenase
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PSAT1 phosphoserine aminotransferase 1
PTN pleiotrophin
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SATB1 SATB homeobox 1
SCRG1 stimulator of chondrogenesis 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SLC3A1 solute carrier family 3 (amino acid transporter heavy chain), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPRR3 small proline-rich protein 3
TFRC transferrin receptor
WARS tryptophanyl-tRNA synthetase
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
ZNF274 zinc finger protein 274