BRD-K02708799_GSK-1059615_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

164 genes differentially expressed following the BRD-K02708799_GSK-1059615_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6
ACTA2 actin, alpha 2, smooth muscle, aorta
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AIM1 absent in melanoma 1
ALDH6A1 aldehyde dehydrogenase 6 family, member A1
ALDOA aldolase A, fructose-bisphosphate
ANK2 ankyrin 2, neuronal
ASPN asporin
ASS1 argininosuccinate synthase 1
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BMP4 bone morphogenetic protein 4
BRD3 bromodomain containing 3
C14ORF132 chromosome 14 open reading frame 132
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CES2 carboxylesterase 2
CFD complement factor D (adipsin)
CFLAR CASP8 and FADD-like apoptosis regulator
CNN3 calponin 3, acidic
COL1A2 collagen, type I, alpha 2
COL6A3 collagen, type VI, alpha 3
CPE carboxypeptidase E
CRELD2 cysteine-rich with EGF-like domains 2
CTGF connective tissue growth factor
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DENND2D DENN/MADD domain containing 2D
DEPTOR DEP domain containing MTOR-interacting protein
EIF5A eukaryotic translation initiation factor 5A
EMP1 epithelial membrane protein 1
FBLN1 fibulin 1
FGFR3 fibroblast growth factor receptor 3
FHL1 four and a half LIM domains 1
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GOLM1 golgi membrane protein 1
GPC1 glypican 1
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX3 glutathione peroxidase 3
GREM1 gremlin 1, DAN family BMP antagonist
GRK5 G protein-coupled receptor kinase 5
GRN granulin
HACD1 3-hydroxyacyl-CoA dehydratase 1
HEBP2 heme binding protein 2
HIST3H2A histone cluster 3, H2a
HLA-B major histocompatibility complex, class I, B
HOOK2 hook microtubule-tethering protein 2
IGFBP6 insulin-like growth factor binding protein 6
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KCTD5 potassium channel tetramerization domain containing 5
KIAA0226L KIAA0226-like
LINC00341 long intergenic non-protein coding RNA 341
LOC100272216 uncharacterized LOC100272216
MAP2K5 mitogen-activated protein kinase kinase 5
MAST4 microtubule associated serine/threonine kinase family member 4
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
METTL7A methyltransferase like 7A
MMP2 matrix metallopeptidase 2
MN1 meningioma (disrupted in balanced translocation) 1
MSRB2 methionine sulfoxide reductase B2
MYBPC1 myosin binding protein C, slow type
MYO5C myosin VC
NEB nebulin
NEBL nebulette
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
NIPSNAP1 nipsnap homolog 1 (C. elegans)
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PLAC8 placenta-specific 8
PPL periplakin
PRAF2 PRA1 domain family, member 2
PRKCB protein kinase C, beta
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RBKS ribokinase
RFC5 replication factor C (activator 1) 5, 36.5kDa
S100P S100 calcium binding protein P
SH3BP4 SH3-domain binding protein 4
SHROOM2 shroom family member 2
SLC11A2 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SMYD3 SET and MYND domain containing 3
SOX11 SRY (sex determining region Y)-box 11
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
SYNM synemin, intermediate filament protein
TCF4 transcription factor 4
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TM7SF2 transmembrane 7 superfamily member 2
TMSB15A thymosin beta 15a
TPM2 tropomyosin 2 (beta)
TRIM2 tripartite motif containing 2
TSPAN6 tetraspanin 6
TSPAN7 tetraspanin 7
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
VCAN versican
WDTC1 WD and tetratricopeptide repeats 1
ZKSCAN1 zinc finger with KRAB and SCAN domains 1

decreased expression

Symbol Name
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACSL1 acyl-CoA synthetase long-chain family member 1
ALDOC aldolase C, fructose-bisphosphate
BCHE butyrylcholinesterase
BICC1 BicC family RNA binding protein 1
BIRC2 baculoviral IAP repeat containing 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
C7 complement component 7
CA2 carbonic anhydrase II
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CD36 CD36 molecule (thrombospondin receptor)
CDA cytidine deaminase
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CLEC7A C-type lectin domain family 7, member A
CPM carboxypeptidase M
CTSZ cathepsin Z
ENO1 enolase 1, (alpha)
EPHA3 EPH receptor A3
ETFA electron-transfer-flavoprotein, alpha polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FXYD6 FXYD domain containing ion transport regulator 6
GPM6B glycoprotein M6B
GRWD1 glutamate-rich WD repeat containing 1
HMOX1 heme oxygenase 1
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2
HSPA1A heat shock 70kDa protein 1A
IGFBP1 insulin-like growth factor binding protein 1
IL1R2 interleukin 1 receptor, type II
KCTD12 potassium channel tetramerization domain containing 12
KRT14 keratin 14, type I
LEF1 lymphoid enhancer-binding factor 1
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
MPPED2 metallophosphoesterase domain containing 2
MRPS2 mitochondrial ribosomal protein S2
MUC4 mucin 4, cell surface associated
ODC1 ornithine decarboxylase 1
PCDH9 protocadherin 9
PIP prolactin-induced protein
PLBD1 phospholipase B domain containing 1
PLK2 polo-like kinase 2
PRDX1 peroxiredoxin 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A12 S100 calcium binding protein A12
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SNAI2 snail family zinc finger 2
SQSTM1 sequestosome 1
TAGLN2 transgelin 2
TCF21 transcription factor 21
TM4SF1 transmembrane 4 L six family member 1
TNPO1 transportin 1
TYRP1 tyrosinase-related protein 1
VDAC1 voltage-dependent anion channel 1
ZFP36L2 ZFP36 ring finger protein-like 2
ZMYM2 zinc finger, MYM-type 2