BRD-K02590140_O-2050_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

125 genes differentially expressed following the BRD-K02590140_O-2050_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1
ADAM9 ADAM metallopeptidase domain 9
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C1QA complement component 1, q subcomponent, A chain
C5AR1 complement component 5a receptor 1
CA1 carbonic anhydrase I
CA12 carbonic anhydrase XII
CD14 CD14 molecule
CD151 CD151 molecule (Raph blood group)
CRABP2 cellular retinoic acid binding protein 2
CST7 cystatin F (leukocystatin)
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDR1 discoidin domain receptor tyrosine kinase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP14 dual specificity phosphatase 14
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
FLOT1 flotillin 1
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
GSTA4 glutathione S-transferase alpha 4
HIST1H1C histone cluster 1, H1c
HIST1H2BK histone cluster 1, H2bk
HMOX1 heme oxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGKC immunoglobulin kappa constant
INHBB inhibin, beta B
KDM5D lysine (K)-specific demethylase 5D
LGALS8 lectin, galactoside-binding, soluble, 8
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MEX3D mex-3 RNA binding family member D
NETO2 neuropilin (NRP) and tolloid (TLL)-like 2
PAIP1 poly(A) binding protein interacting protein 1
PCGF2 polycomb group ring finger 2
PTN pleiotrophin
RGCC regulator of cell cycle
RPS4Y1 ribosomal protein S4, Y-linked 1
RXRA retinoid X receptor, alpha
S100A2 S100 calcium binding protein A2
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SOX11 SRY (sex determining region Y)-box 11
TACSTD2 tumor-associated calcium signal transducer 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIP6 thyroid hormone receptor interactor 6
USP18 ubiquitin specific peptidase 18
VEGFA vascular endothelial growth factor A
VSIG4 V-set and immunoglobulin domain containing 4
ZIC1 Zic family member 1

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ADD3 adducin 3 (gamma)
AHR aryl hydrocarbon receptor
ALB albumin
AZIN1 antizyme inhibitor 1
BEX1 brain expressed, X-linked 1
C6ORF62 chromosome 6 open reading frame 62
C7 complement component 7
CKS2 CDC28 protein kinase regulatory subunit 2
COL14A1 collagen, type XIV, alpha 1
COL1A1 collagen, type I, alpha 1
COLEC11 collectin sub-family member 11
CXCL12 chemokine (C-X-C motif) ligand 12
CYBA cytochrome b-245, alpha polypeptide
CYCS cytochrome c, somatic
DCN decorin
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17
DLC1 DLC1 Rho GTPase activating protein
DUSP22 dual specificity phosphatase 22
DUSP3 dual specificity phosphatase 3
EIF5 eukaryotic translation initiation factor 5
ELF1 E74-like factor 1 (ets domain transcription factor)
F2RL1 coagulation factor II (thrombin) receptor-like 1
FGFR2 fibroblast growth factor receptor 2
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
GPC3 glypican 3
HIST1H2BG histone cluster 1, H2bg
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HSPA8 heat shock 70kDa protein 8
IL6ST interleukin 6 signal transducer
ISL1 ISL LIM homeobox 1
KAT6B K(lysine) acetyltransferase 6B
LAMP5 lysosomal-associated membrane protein family, member 5
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MATN2 matrilin 2
MBNL1 muscleblind-like splicing regulator 1
MGP matrix Gla protein
NOTCH2NL notch 2 N-terminal like
OPN3 opsin 3
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PLK2 polo-like kinase 2
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRPS2 phosphoribosyl pyrophosphate synthetase 2
PRSS3 protease, serine, 3
PSPH phosphoserine phosphatase
PTP4A2 protein tyrosine phosphatase type IVA, member 2
RGS4 regulator of G-protein signaling 4
RPL27A ribosomal protein L27a
RPL37A ribosomal protein L37a
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SCYL3 SCY1-like 3 (S. cerevisiae)
SKAP2 src kinase associated phosphoprotein 2
SLC38A2 solute carrier family 38, member 2
SOX4 SRY (sex determining region Y)-box 4
SPINK1 serine peptidase inhibitor, Kazal type 1
SRSF7 serine/arginine-rich splicing factor 7
SST somatostatin
TFRC transferrin receptor
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TSPAN8 tetraspanin 8
TXNIP thioredoxin interacting protein
VCL vinculin
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta