BRD-K02589376_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

47 genes differentially expressed following the BRD-K02589376_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AKAP12 A kinase (PRKA) anchor protein 12
APP amyloid beta (A4) precursor protein
BAX BCL2-associated X protein
CPA3 carboxypeptidase A3 (mast cell)
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex)
DNAJC7 DnaJ (Hsp40) homolog, subfamily C, member 7
F13A1 coagulation factor XIII, A1 polypeptide
FAM129A family with sequence similarity 129, member A
FHL1 four and a half LIM domains 1
GATAD2A GATA zinc finger domain containing 2A
HIRA histone cell cycle regulator
IGFBP5 insulin-like growth factor binding protein 5
IL17RB interleukin 17 receptor B
LAMP1 lysosomal-associated membrane protein 1
NCAM1 neural cell adhesion molecule 1
PDAP1 PDGFA associated protein 1
PLN phospholamban
RAB11FIP2 RAB11 family interacting protein 2 (class I)
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SELENBP1 selenium binding protein 1
TRIB2 tribbles pseudokinase 2

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ANXA3 annexin A3
ARPP19 cAMP-regulated phosphoprotein, 19kDa
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit
DEPTOR DEP domain containing MTOR-interacting protein
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15
EBNA1BP2 EBNA1 binding protein 2
EMC2 ER membrane protein complex subunit 2
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
KIAA0125 KIAA0125
KLK6 kallikrein-related peptidase 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
NPR3 natriuretic peptide receptor 3
NQO2 NAD(P)H dehydrogenase, quinone 2
NR4A2 nuclear receptor subfamily 4, group A, member 2
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
RAB40B RAB40B, member RAS oncogene family
SGK1 serum/glucocorticoid regulated kinase 1
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SLC25A46 solute carrier family 25, member 46
SMS spermine synthase
TM4SF1 transmembrane 4 L six family member 1
TOP2A topoisomerase (DNA) II alpha 170kDa
XBP1 X-box binding protein 1
XPO1 exportin 1