BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K02581333_Protein Tyrosine Phosphatase Inhibitor IV_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ALOX5AP arachidonate 5-lipoxygenase-activating protein
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2
APOB apolipoprotein B
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARG2 arginase 2
ARMCX2 armadillo repeat containing, X-linked 2
AZGP1 alpha-2-glycoprotein 1, zinc-binding
C10ORF10 chromosome 10 open reading frame 10
CCDC86 coiled-coil domain containing 86
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CLU clusterin
CNN3 calponin 3, acidic
CP ceruloplasmin (ferroxidase)
CRABP2 cellular retinoic acid binding protein 2
DUSP1 dual specificity phosphatase 1
EREG epiregulin
EXT1 exostosin glycosyltransferase 1
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCHO1 FCH domain only 1
GJA1 gap junction protein, alpha 1, 43kDa
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class)
GPNMB glycoprotein (transmembrane) nmb
HDAC9 histone deacetylase 9
HSPA1A heat shock 70kDa protein 1A
IFNAR1 interferon (alpha, beta and omega) receptor 1
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
JCHAIN joining chain of multimeric IgA and IgM
KRT19 keratin 19, type I
KRT23 keratin 23, type I
LAPTM4B lysosomal protein transmembrane 4 beta
LDOC1 leucine zipper, down-regulated in cancer 1
MMD monocyte to macrophage differentiation-associated
MTA1 metastasis associated 1
MUC16 mucin 16, cell surface associated
NFIL3 nuclear factor, interleukin 3 regulated
NNMT nicotinamide N-methyltransferase
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
NXN nucleoredoxin
ORC1 origin recognition complex, subunit 1
ORM1 orosomucoid 1
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PEA15 phosphoprotein enriched in astrocytes 15
PEG10 paternally expressed 10
PFKM phosphofructokinase, muscle
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
PMP22 peripheral myelin protein 22
PON3 paraoxonase 3
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
RTN2 reticulon 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
STAP1 signal transducing adaptor family member 1
STC2 stanniocalcin 2
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TGFB1 transforming growth factor, beta 1
TM4SF1 transmembrane 4 L six family member 1
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMPRSS3 transmembrane protease, serine 3
TNNT1 troponin T type 1 (skeletal, slow)
TPM4 tropomyosin 4
TRIB3 tribbles pseudokinase 3
VTCN1 V-set domain containing T cell activation inhibitor 1
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8
ABHD2 abhydrolase domain containing 2
ADIRF adipogenesis regulatory factor
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
AMACR alpha-methylacyl-CoA racemase
ASPA aspartoacylase
BIRC2 baculoviral IAP repeat containing 2
CALB1 calbindin 1, 28kDa
CBR3 carbonyl reductase 3
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
COL9A3 collagen, type IX, alpha 3
COX5A cytochrome c oxidase subunit Va
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSH cathepsin H
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL3 chemokine (C-X-C motif) ligand 3
DACH1 dachshund family transcription factor 1
DHRS9 dehydrogenase/reductase (SDR family) member 9
DKK1 dickkopf WNT signaling pathway inhibitor 1
EDNRB endothelin receptor type B
EGFR epidermal growth factor receptor
EGR3 early growth response 3
ENPP1 ectonucleotide pyrophosphatase/phosphodiesterase 1
ERAP2 endoplasmic reticulum aminopeptidase 2
FABP7 fatty acid binding protein 7, brain
FOLR1 folate receptor 1 (adult)
GAA glucosidase, alpha; acid
GAS7 growth arrest-specific 7
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1
GPATCH8 G patch domain containing 8
GPM6B glycoprotein M6B
HES1 hes family bHLH transcription factor 1
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
ITGA6 integrin, alpha 6
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
LAMC2 laminin, gamma 2
LPCAT1 lysophosphatidylcholine acyltransferase 1
MAGT1 magnesium transporter 1
METTL7A methyltransferase like 7A
MFAP3L microfibrillar-associated protein 3-like
MGP matrix Gla protein
MID1 midline 1
MYH11 myosin, heavy chain 11, smooth muscle
NFIB nuclear factor I/B
NGRN neugrin, neurite outgrowth associated
NR2F2 nuclear receptor subfamily 2, group F, member 2
OLFML2B olfactomedin-like 2B
PCDH9 protocadherin 9
PDZK1 PDZ domain containing 1
PEBP1 phosphatidylethanolamine binding protein 1
PLP1 proteolipid protein 1
PODXL podocalyxin-like
PPAP2A phosphatidic acid phosphatase type 2A
RBMS1 RNA binding motif, single stranded interacting protein 1
RELN reelin
RNASET2 ribonuclease T2
RPL38 ribosomal protein L38
RPS11 ribosomal protein S11
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SLC39A8 solute carrier family 39 (zinc transporter), member 8
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2
SYNE1 spectrin repeat containing, nuclear envelope 1
SYT1 synaptotagmin I
TBX2 T-box 2
TFF3 trefoil factor 3 (intestinal)
THBS1 thrombospondin 1
TMEM47 transmembrane protein 47
TMEM87A transmembrane protein 87A
TSPAN8 tetraspanin 8
VSNL1 visinin-like 1
WIF1 WNT inhibitory factor 1
ZBTB18 zinc finger and BTB domain containing 18
ZBTB20 zinc finger and BTB domain containing 20