BRD-K02113016_olaparib_PC3_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

175 genes differentially expressed following the BRD-K02113016_olaparib_PC3_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABAT 4-aminobutyrate aminotransferase
ACTG2 actin, gamma 2, smooth muscle, enteric
ADAM19 ADAM metallopeptidase domain 19
AKAP12 A kinase (PRKA) anchor protein 12
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH1A1 aldehyde dehydrogenase 1 family, member A1
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ANPEP alanyl (membrane) aminopeptidase
AQP3 aquaporin 3 (Gill blood group)
ASS1 argininosuccinate synthase 1
BASP1 brain abundant, membrane attached signal protein 1
C3 complement component 3
C7 complement component 7
CALD1 caldesmon 1
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CLCA4 chloride channel accessory 4
CLIP3 CAP-GLY domain containing linker protein 3
COBL cordon-bleu WH2 repeat protein
COG7 component of oligomeric golgi complex 7
COL9A3 collagen, type IX, alpha 3
COLEC12 collectin sub-family member 12
CRYAB crystallin, alpha B
CSTA cystatin A (stefin A)
DBN1 drebrin 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EFS embryonal Fyn-associated substrate
EGR1 early growth response 1
EHD3 EH-domain containing 3
ENPP2 ectonucleotide pyrophosphatase/phosphodiesterase 2
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
FGFR3 fibroblast growth factor receptor 3
FGL2 fibrinogen-like 2
FHL1 four and a half LIM domains 1
FLRT2 fibronectin leucine rich transmembrane protein 2
FRY furry homolog (Drosophila)
FXYD1 FXYD domain containing ion transport regulator 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPATCH8 G patch domain containing 8
GPC3 glypican 3
GSTA1 glutathione S-transferase alpha 1
GYPC glycophorin C (Gerbich blood group)
HLA-DRA major histocompatibility complex, class II, DR alpha
IGF1R insulin-like growth factor 1 receptor
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IL6 interleukin 6
IRF4 interferon regulatory factor 4
IRS2 insulin receptor substrate 2
ITIH5 inter-alpha-trypsin inhibitor heavy chain family, member 5
KIF5C kinesin family member 5C
KRT15 keratin 15, type I
KYNU kynureninase
LINC00341 long intergenic non-protein coding RNA 341
LOC100505650 uncharacterized LOC100505650
LYN LYN proto-oncogene, Src family tyrosine kinase
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MARCKS myristoylated alanine-rich protein kinase C substrate
MBNL2 muscleblind-like splicing regulator 2
MDFIC MyoD family inhibitor domain containing
MFAP5 microfibrillar associated protein 5
MYH11 myosin, heavy chain 11, smooth muscle
NAV3 neuron navigator 3
NDNF neuron-derived neurotrophic factor
NFIL3 nuclear factor, interleukin 3 regulated
NID2 nidogen 2 (osteonidogen)
NUAK1 NUAK family, SNF1-like kinase, 1
OGN osteoglycin
P3H2 prolyl 3-hydroxylase 2
PDE4B phosphodiesterase 4B, cAMP-specific
PDGFD platelet derived growth factor D
PEG10 paternally expressed 10
PLSCR4 phospholipid scramblase 4
PON3 paraoxonase 3
POSTN periostin, osteoblast specific factor
PPAP2A phosphatidic acid phosphatase type 2A
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PRELP proline/arginine-rich end leucine-rich repeat protein
PRR7 proline rich 7 (synaptic)
PTCH1 patched 1
PTN pleiotrophin
PTPRD protein tyrosine phosphatase, receptor type, D
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RBKS ribokinase
RGS10 regulator of G-protein signaling 10
RGS2 regulator of G-protein signaling 2
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
RPS4Y1 ribosomal protein S4, Y-linked 1
RRAS2 related RAS viral (r-ras) oncogene homolog 2
S100A2 S100 calcium binding protein A2
SASH1 SAM and SH3 domain containing 1
SDPR serum deprivation response
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SYT1 synaptotagmin I
TARBP1 TAR (HIV-1) RNA binding protein 1
TCF4 transcription factor 4
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
TLE4 transducin-like enhancer of split 4
TMEM243 transmembrane protein 243, mitochondrial
TMEM47 transmembrane protein 47
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TPPP3 tubulin polymerization-promoting protein family member 3
TRIB2 tribbles pseudokinase 2
TSC22D3 TSC22 domain family, member 3
TSPAN7 tetraspanin 7
UGT2B28 UDP glucuronosyltransferase 2 family, polypeptide B28
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
ANO1 anoctamin 1, calcium activated chloride channel
ARL8B ADP-ribosylation factor-like 8B
ASPN asporin
ATF3 activating transcription factor 3
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
C8ORF4 chromosome 8 open reading frame 4
CD163 CD163 molecule
CD47 CD47 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
DACH1 dachshund family transcription factor 1
DSP desmoplakin
FAR2 fatty acyl CoA reductase 2
FST follistatin
GEM GTP binding protein overexpressed in skeletal muscle
GLO1 glyoxalase I
HEXB hexosaminidase B (beta polypeptide)
HPCAL1 hippocalcin-like 1
HSPD1 heat shock 60kDa protein 1 (chaperonin)
IFI44L interferon-induced protein 44-like
IFIH1 interferon induced with helicase C domain 1
INHBA inhibin, beta A
ITGAV integrin, alpha V
ITGB1BP1 integrin beta 1 binding protein 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
KIAA0196 KIAA0196
KRT1 keratin 1, type II
LCP1 lymphocyte cytosolic protein 1 (L-plastin)
LPL lipoprotein lipase
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MTSS1 metastasis suppressor 1
NUP62 nucleoporin 62kDa
PGK1 phosphoglycerate kinase 1
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PLAU plasminogen activator, urokinase
PLAUR plasminogen activator, urokinase receptor
PLIN2 perilipin 2
PTTG1IP pituitary tumor-transforming 1 interacting protein
SHB Src homology 2 domain containing adaptor protein B
SKP1 S-phase kinase-associated protein 1
SLC30A1 solute carrier family 30 (zinc transporter), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMYD3 SET and MYND domain containing 3
SOX9 SRY (sex determining region Y)-box 9
SQLE squalene epoxidase
TACC1 transforming, acidic coiled-coil containing protein 1
TKTL1 transketolase-like 1
TSC22D1 TSC22 domain family, member 1
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1