BRD-K02113016_olaparib_A375_24_h_0.04_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

71 genes differentially expressed following the BRD-K02113016_olaparib_A375_24_h_0.04_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ACSM3 acyl-CoA synthetase medium-chain family member 3
ADIPOQ adiponectin, C1Q and collagen domain containing
AKR1C1 aldo-keto reductase family 1, member C1
ANXA4 annexin A4
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
AUTS2 autism susceptibility candidate 2
CD24 CD24 molecule
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6
FLNB filamin B, beta
GDF15 growth differentiation factor 15
GSN gelsolin
GSTP1 glutathione S-transferase pi 1
HBE1 hemoglobin, epsilon 1
HOOK2 hook microtubule-tethering protein 2
HOXC10 homeobox C10
KANK1 KN motif and ankyrin repeat domains 1
KRT16 keratin 16, type I
KRT17 keratin 17, type I
KRT18 keratin 18, type I
NUPR1 nuclear protein, transcriptional regulator, 1
PPL periplakin
RAB38 RAB38, member RAS oncogene family
RBP4 retinol binding protein 4, plasma
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SOX9 SRY (sex determining region Y)-box 9
VDAC1 voltage-dependent anion channel 1

decreased expression

Symbol Name
AGTR1 angiotensin II receptor, type 1
AREG amphiregulin
CCNB1 cyclin B1
CCNE2 cyclin E2
COL6A2 collagen, type VI, alpha 2
CP ceruloplasmin (ferroxidase)
CRELD2 cysteine-rich with EGF-like domains 2
CTGF connective tissue growth factor
DCN decorin
EBP emopamil binding protein (sterol isomerase)
FBXL12 F-box and leucine-rich repeat protein 12
FCGBP Fc fragment of IgG binding protein
FOLR1 folate receptor 1 (adult)
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IFI27 interferon, alpha-inducible protein 27
IFI44 interferon-induced protein 44
IFIT2 interferon-induced protein with tetratricopeptide repeats 2
ISG15 ISG15 ubiquitin-like modifier
MT1E metallothionein 1E
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1H metallothionein 1H
MT1HL1 metallothionein 1H-like 1
MT1M metallothionein 1M
MT1X metallothionein 1X
MT2A metallothionein 2A
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PPIF peptidylprolyl isomerase F
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PUF60 poly-U binding splicing factor 60KDa
RND3 Rho family GTPase 3
RRM2 ribonucleotide reductase M2
SGCE sarcoglycan, epsilon
SPINK1 serine peptidase inhibitor, Kazal type 1
SPON2 spondin 2, extracellular matrix protein
SPRED2 sprouty-related, EVH1 domain containing 2
STK10 serine/threonine kinase 10
VCAN versican