BRD-K02113016_AZD2281 (KU59436)_NCIH2073_6.0_h_44.4_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

109 genes differentially expressed following the BRD-K02113016_AZD2281 (KU59436)_NCIH2073_6.0_h_44.4_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
BAALC brain and acute leukemia, cytoplasmic
BANK1 B-cell scaffold protein with ankyrin repeats 1
CDH3 cadherin 3, type 1, P-cadherin (placental)
CLCA2 chloride channel accessory 2
EEF2 eukaryotic translation elongation factor 2
EXOSC4 exosome component 4
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14
GLS glutaminase
GNA11 guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
GYPC glycophorin C (Gerbich blood group)
HILPDA hypoxia inducible lipid droplet-associated
HP haptoglobin
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IKZF1 IKAROS family zinc finger 1 (Ikaros)
KAZN kazrin, periplakin interacting protein
KLF4 Kruppel-like factor 4 (gut)
LAPTM4B lysosomal protein transmembrane 4 beta
MAMLD1 mastermind-like domain containing 1
NOV nephroblastoma overexpressed
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PRTN3 proteinase 3
PXMP2 peroxisomal membrane protein 2, 22kDa
S100A11 S100 calcium binding protein A11
S100A12 S100 calcium binding protein A12
S100A9 S100 calcium binding protein A9
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SFN stratifin
SFTPB surfactant protein B
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
TRAF3IP2 TRAF3 interacting protein 2
TSC22D1 TSC22 domain family, member 1
TSKU tsukushi, small leucine rich proteoglycan
TSPAN13 tetraspanin 13
VLDLR very low density lipoprotein receptor
XIST X inactive specific transcript (non-protein coding)

decreased expression

Symbol Name
ACAA2 acetyl-CoA acyltransferase 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADI1 acireductone dioxygenase 1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPN asporin
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CALD1 caldesmon 1
CAST calpastatin
CD36 CD36 molecule (thrombospondin receptor)
CD52 CD52 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CHIC2 cysteine-rich hydrophobic domain 2
CLGN calmegin
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family)
COL10A1 collagen, type X, alpha 1
COL1A1 collagen, type I, alpha 1
COL5A1 collagen, type V, alpha 1
COL5A2 collagen, type V, alpha 2
CPE carboxypeptidase E
CSRP1 cysteine and glycine-rich protein 1
CTSK cathepsin K
CXCL14 chemokine (C-X-C motif) ligand 14
CYB5A cytochrome b5 type A (microsomal)
DCN decorin
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
FABP4 fatty acid binding protein 4, adipocyte
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FGFR2 fibroblast growth factor receptor 2
FILIP1L filamin A interacting protein 1-like
FLRT2 fibronectin leucine rich transmembrane protein 2
FN1 fibronectin 1
FST follistatin
GLIPR1 GLI pathogenesis-related 1
HOPX HOP homeobox
HSPA1A heat shock 70kDa protein 1A
HTRA1 HtrA serine peptidase 1
KIF20A kinesin family member 20A
LHFP lipoma HMGIC fusion partner
MMD monocyte to macrophage differentiation-associated
MPC1 mitochondrial pyruvate carrier 1
NAV2 neuron navigator 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
PCDH9 protocadherin 9
PCM1 pericentriolar material 1
PDGFRL platelet-derived growth factor receptor-like
PEG10 paternally expressed 10
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLK1 polo-like kinase 1
POLB polymerase (DNA directed), beta
PSPH phosphoserine phosphatase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
SCUBE2 signal peptide, CUB domain, EGF-like 2
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SFRP4 secreted frizzled-related protein 4
SGCE sarcoglycan, epsilon
SOX9 SRY (sex determining region Y)-box 9
SPINK1 serine peptidase inhibitor, Kazal type 1
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
SRGN serglycin
STK10 serine/threonine kinase 10
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae)
TAGLN transgelin
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TMX4 thioredoxin-related transmembrane protein 4
TSPYL5 TSPY-like 5
TUBA1A tubulin, alpha 1a
UBE2E3 ubiquitin-conjugating enzyme E2E 3
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
ZNF185 zinc finger protein 185 (LIM domain)
ZNF532 zinc finger protein 532