BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_NCIH2073_6.0_h_0.63_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

185 genes differentially expressed following the BRD-K01976263_Emetine Dihydrochloride Hydrate (74)_NCIH2073_6.0_h_0.63_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
ARG1 arginase 1
ARHGAP29 Rho GTPase activating protein 29
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1
ATF1 activating transcription factor 1
ATF3 activating transcription factor 3
BEX1 brain expressed, X-linked 1
BIRC3 baculoviral IAP repeat containing 3
BMP2 bone morphogenetic protein 2
CADM1 cell adhesion molecule 1
CCL2 chemokine (C-C motif) ligand 2
CDKN2AIP CDKN2A interacting protein
CFLAR CASP8 and FADD-like apoptosis regulator
CHIC2 cysteine-rich hydrophobic domain 2
CLU clusterin
CXCL8 chemokine (C-X-C motif) ligand 8
CYR61 cysteine-rich, angiogenic inducer, 61
DIO1 deiodinase, iodothyronine, type I
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DNMBP dynamin binding protein
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
EGFR epidermal growth factor receptor
EHD1 EH-domain containing 1
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
EXOSC4 exosome component 4
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM46A family with sequence similarity 46, member A
FGF13 fibroblast growth factor 13
FHL2 four and a half LIM domains 2
FOSL1 FOS-like antigen 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GATA3 GATA binding protein 3
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GEM GTP binding protein overexpressed in skeletal muscle
GNAS GNAS complex locus
GPRC5A G protein-coupled receptor, class C, group 5, member A
GRB14 growth factor receptor-bound protein 14
HAL histidine ammonia-lyase
HIST1H1C histone cluster 1, H1c
HP haptoglobin
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
JAM3 junctional adhesion molecule 3
JMJD1C jumonji domain containing 1C
JUN jun proto-oncogene
KCTD5 potassium channel tetramerization domain containing 5
KLF10 Kruppel-like factor 10
KLF4 Kruppel-like factor 4 (gut)
KLF6 Kruppel-like factor 6
KLF7 Kruppel-like factor 7 (ubiquitous)
LIF leukemia inhibitory factor
LMCD1 LIM and cysteine-rich domains 1
MIR22HG MIR22 host gene
MYC v-myc avian myelocytomatosis viral oncogene homolog
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A3 nuclear receptor subfamily 4, group A, member 3
NRG1 neuregulin 1
NRIP1 nuclear receptor interacting protein 1
NUP98 nucleoporin 98kDa
PALLD palladin, cytoskeletal associated protein
PDLIM5 PDZ and LIM domain 5
PFDN2 prefoldin subunit 2
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTBP2 polypyrimidine tract binding protein 2
RBM15 RNA binding motif protein 15
RDX radixin
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS2 regulator of G-protein signaling 2
RIPK2 receptor-interacting serine-threonine kinase 2
RRAS2 related RAS viral (r-ras) oncogene homolog 2
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast)
RYBP RING1 and YY1 binding protein
S100P S100 calcium binding protein P
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK3 SIK family kinase 3
SWAP70 SWAP switching B-cell complex 70kDa subunit
TG thyroglobulin
TKTL1 transketolase-like 1
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TP53BP2 tumor protein p53 binding protein 2
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNL4B thioredoxin-like 4B
WEE1 WEE1 G2 checkpoint kinase

decreased expression

Symbol Name
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4
ADAM9 ADAM metallopeptidase domain 9
ADD3 adducin 3 (gamma)
AKAP1 A kinase (PRKA) anchor protein 1
ANXA4 annexin A4
ATP2A3 ATPase, Ca++ transporting, ubiquitous
B3GNT1
BCHE butyrylcholinesterase
C1QA complement component 1, q subcomponent, A chain
CCL5 chemokine (C-C motif) ligand 5
CCL8 chemokine (C-C motif) ligand 8
CD46 CD46 molecule, complement regulatory protein
CFB complement factor B
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHST1 carbohydrate (keratan sulfate Gal-6) sulfotransferase 1
CSRP1 cysteine and glycine-rich protein 1
CTSZ cathepsin Z
CXCL11 chemokine (C-X-C motif) ligand 11
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FBLN1 fibulin 1
FKBP11 FK506 binding protein 11, 19 kDa
G6PD glucose-6-phosphate dehydrogenase
GAS1 growth arrest-specific 1
GPD1L glycerol-3-phosphate dehydrogenase 1-like
GRN granulin
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3)
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMG20B high mobility group 20B
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGKV4-1 immunoglobulin kappa variable 4-1
IGL immunoglobulin lambda locus
KAZN kazrin, periplakin interacting protein
KRT18 keratin 18, type I
LIPA lipase A, lysosomal acid, cholesterol esterase
LPAR6 lysophosphatidic acid receptor 6
LUM lumican
LYPD1 LY6/PLAUR domain containing 1
MDFIC MyoD family inhibitor domain containing
MEIS1 Meis homeobox 1
MEIS2 Meis homeobox 2
MLEC malectin
MMP12 matrix metallopeptidase 12
MN1 meningioma (disrupted in balanced translocation) 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEFH neurofilament, heavy polypeptide
NPTX2 neuronal pentraxin II
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PDIA6 protein disulfide isomerase family A, member 6
PERP PERP, TP53 apoptosis effector
PKM pyruvate kinase, muscle
PLBD1 phospholipase B domain containing 1
RAD51C RAD51 paralog C
RBP1 retinol binding protein 1, cellular
RPA1 replication protein A1, 70kDa
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCPEP1 serine carboxypeptidase 1
SEL1L sel-1 suppressor of lin-12-like (C. elegans)
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SNX10 sorting nexin 10
SYNM synemin, intermediate filament protein
TBC1D16 TBC1 domain family, member 16
TBC1D31 TBC1 domain family, member 31
TDO2 tryptophan 2,3-dioxygenase
TGFB1 transforming growth factor, beta 1
TM4SF1 transmembrane 4 L six family member 1
TMEM14A transmembrane protein 14A
TMEM45A transmembrane protein 45A
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TP53TG1 TP53 target 1 (non-protein coding)
TPM2 tropomyosin 2 (beta)
TUSC3 tumor suppressor candidate 3
UNC13B unc-13 homolog B (C. elegans)
VLDLR very low density lipoprotein receptor
XCL1 chemokine (C motif) ligand 1
ZNF586 zinc finger protein 586