BRD-K01877528_TL_HRAS26 BRD-K01877528_VCAP_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

131 genes differentially expressed following the BRD-K01877528_TL_HRAS26 BRD-K01877528_VCAP_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACTA2 actin, alpha 2, smooth muscle, aorta
ADM adrenomedullin
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ANXA1 annexin A1
APOLD1 apolipoprotein L domain containing 1
ASPH aspartate beta-hydroxylase
ATF3 activating transcription factor 3
C1S complement component 1, s subcomponent
CA4 carbonic anhydrase IV
CDH1 cadherin 1, type 1, E-cadherin (epithelial)
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CDK14 cyclin-dependent kinase 14
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEACAM7 carcinoembryonic antigen-related cell adhesion molecule 7
CFD complement factor D (adipsin)
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A3 collagen, type VI, alpha 3
CTSZ cathepsin Z
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DENND2D DENN/MADD domain containing 2D
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DPYSL3 dihydropyrimidinase-like 3
EMP1 epithelial membrane protein 1
EPB41L4B erythrocyte membrane protein band 4.1 like 4B
FABP1 fatty acid binding protein 1, liver
FABP4 fatty acid binding protein 4, adipocyte
FAM107A family with sequence similarity 107, member A
FCGBP Fc fragment of IgG binding protein
FHL1 four and a half LIM domains 1
FOXG1 forkhead box G1
FTH1 ferritin, heavy polypeptide 1
G0S2 G0/G1 switch 2
GABARAPL1 GABA(A) receptor-associated protein like 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GBP1 guanylate binding protein 1, interferon-inducible
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPX2 glutathione peroxidase 2
HBB hemoglobin, beta
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
KIF14 kinesin family member 14
KRT20 keratin 20, type I
LEF1 lymphoid enhancer-binding factor 1
LEFTY1 left-right determination factor 1
LRRC15 leucine rich repeat containing 15
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MME membrane metallo-endopeptidase
MT1M metallothionein 1M
MXRA5 matrix-remodelling associated 5
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
OLFM4 olfactomedin 4
PDE4B phosphodiesterase 4B, cAMP-specific
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PIP prolactin-induced protein
PKP2 plakophilin 2
POSTN periostin, osteoblast specific factor
PPARG peroxisome proliferator-activated receptor gamma
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTN pleiotrophin
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila)
S100A8 S100 calcium binding protein A8
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDCBP syndecan binding protein (syntenin)
SEPP1 selenoprotein P, plasma, 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SGK1 serum/glucocorticoid regulated kinase 1
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SNAI2 snail family zinc finger 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPARCL1 SPARC-like 1 (hevin)
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRAC T cell receptor alpha constant
TSPAN8 tetraspanin 8
TUBB6 tubulin, beta 6 class V
TXNRD1 thioredoxin reductase 1
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UGDH UDP-glucose 6-dehydrogenase
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VTCN1 V-set domain containing T cell activation inhibitor 1
VWF von Willebrand factor

decreased expression

Symbol Name
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
AQP3 aquaporin 3 (Gill blood group)
CCNE2 cyclin E2
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
COG2 component of oligomeric golgi complex 2
CYBA cytochrome b-245, alpha polypeptide
DCTD dCMP deaminase
ESR1 estrogen receptor 1
FGFR3 fibroblast growth factor receptor 3
GATA2 GATA binding protein 2
HOMER2 homer scaffolding protein 2
HSPA8 heat shock 70kDa protein 8
ICMT isoprenylcysteine carboxyl methyltransferase
KAZN kazrin, periplakin interacting protein
KCNN2 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 2
KIF20A kinesin family member 20A
NXN nucleoredoxin
PCNA proliferating cell nuclear antigen
PDLIM4 PDZ and LIM domain 4
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PLK1 polo-like kinase 1
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRDX2 peroxiredoxin 2
SDC4 syndecan 4
SEPW1 selenoprotein W, 1
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFRP1 secreted frizzled-related protein 1
TES testin LIM domain protein
TP53 tumor protein p53
TXNIP thioredoxin interacting protein
VAMP8 vesicle-associated membrane protein 8