BRD-K01877528_TL_HRAS26 BRD-K01877528_HCC515_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

146 genes differentially expressed following the BRD-K01877528_TL_HRAS26 BRD-K01877528_HCC515_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALOX5AP arachidonate 5-lipoxygenase-activating protein
ATF3 activating transcription factor 3
AUTS2 autism susceptibility candidate 2
BAG3 BCL2-associated athanogene 3
BTG2 BTG family, member 2
CCL4 chemokine (C-C motif) ligand 4
CDK14 cyclin-dependent kinase 14
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL10A1 collagen, type X, alpha 1
COL9A2 collagen, type IX, alpha 2
CTSB cathepsin B
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DENND1B DENN/MADD domain containing 1B
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DUSP1 dual specificity phosphatase 1
DUSP2 dual specificity phosphatase 2
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
FBP1 fructose-1,6-bisphosphatase 1
FGL2 fibrinogen-like 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GAB2 GRB2-associated binding protein 2
GPNMB glycoprotein (transmembrane) nmb
GRB7 growth factor receptor-bound protein 7
HBB hemoglobin, beta
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
IER2 immediate early response 2
IER5 immediate early response 5
IGKC immunoglobulin kappa constant
IGL immunoglobulin lambda locus
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
MFAP2 microfibrillar-associated protein 2
MMP10 matrix metallopeptidase 10
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
NACA nascent polypeptide-associated complex alpha subunit
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NFIL3 nuclear factor, interleukin 3 regulated
PLEKHO1 pleckstrin homology domain containing, family O member 1
PLIN2 perilipin 2
PLXNA1 plexin A1
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRG2 proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
PTN pleiotrophin
PTPRO protein tyrosine phosphatase, receptor type, O
RGCC regulator of cell cycle
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SDC1 syndecan 1
SELENBP1 selenium binding protein 1
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SERTAD2 SERTA domain containing 2
SFRP4 secreted frizzled-related protein 4
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
STS steroid sulfatase (microsomal), isozyme S
SULF1 sulfatase 1
TRIB1 tribbles pseudokinase 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XIST X inactive specific transcript (non-protein coding)
ZFP36 ZFP36 ring finger protein
ZNF395 zinc finger protein 395

decreased expression

Symbol Name
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALCAM activated leukocyte cell adhesion molecule
ARHGAP29 Rho GTPase activating protein 29
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPH aspartate beta-hydroxylase
BASP1 brain abundant, membrane attached signal protein 1
CAV1 caveolin 1, caveolae protein, 22kDa
CDC14B cell division cycle 14B
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CLU clusterin
CPS1 carbamoyl-phosphate synthase 1, mitochondrial
CRIP1 cysteine-rich protein 1 (intestinal)
DAPK1 death-associated protein kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta
EHBP1 EH domain binding protein 1
FLRT2 fibronectin leucine rich transmembrane protein 2
GRWD1 glutamate-rich WD repeat containing 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IGFBP6 insulin-like growth factor binding protein 6
IL6ST interleukin 6 signal transducer
IRS2 insulin receptor substrate 2
JADE1 jade family PHD finger 1
KIF1BP KIF1 binding protein
KIF5C kinesin family member 5C
KRT10 keratin 10, type I
KRT7 keratin 7, type II
LAMB1 laminin, beta 1
LIPG lipase, endothelial
LMO2 LIM domain only 2 (rhombotin-like 1)
MARCKSL1 MARCKS-like 1
MSH6 mutS homolog 6
NDN necdin, melanoma antigen (MAGE) family member
PKN2 protein kinase N2
PRKCH protein kinase C, eta
PTCH1 patched 1
PTGES prostaglandin E synthase
RANBP6 RAN binding protein 6
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOBTB3 Rho-related BTB domain containing 3
RUVBL1 RuvB-like AAA ATPase 1
SCYL3 SCY1-like 3 (S. cerevisiae)
SEPT11 septin 11
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SFRP1 secreted frizzled-related protein 1
SHQ1 SHQ1, H/ACA ribonucleoprotein assembly factor
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORBS1 sorbin and SH3 domain containing 1
SRPX sushi-repeat containing protein, X-linked
SRSF6 serine/arginine-rich splicing factor 6
TBC1D4 TBC1 domain family, member 4
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM260 transmembrane protein 260
TMEM47 transmembrane protein 47
TNC tenascin C
TSPAN13 tetraspanin 13
TSPAN4 tetraspanin 4
VCAN versican