BRD-K01877528_TL_HRAS26 BRD-K01877528_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

161 genes differentially expressed following the BRD-K01877528_TL_HRAS26 BRD-K01877528_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ACKR3 atypical chemokine receptor 3
ADM adrenomedullin
ALDOC aldolase C, fructose-bisphosphate
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BCL3 B-cell CLL/lymphoma 3
BHLHE40 basic helix-loop-helix family, member e40
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
C10ORF10 chromosome 10 open reading frame 10
C1QA complement component 1, q subcomponent, A chain
CASP10 caspase 10, apoptosis-related cysteine peptidase
CCL4 chemokine (C-C motif) ligand 4
CD163 CD163 molecule
CD164 CD164 molecule, sialomucin
CD40 CD40 molecule, TNF receptor superfamily member 5
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD69 CD69 molecule
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
COL6A2 collagen, type VI, alpha 2
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EFNA1 ephrin-A1
EGR1 early growth response 1
EIF1 eukaryotic translation initiation factor 1
ENO2 enolase 2 (gamma, neuronal)
EPAS1 endothelial PAS domain protein 1
FADS1 fatty acid desaturase 1
FAM134B family with sequence similarity 134, member B
FBN2 fibrillin 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
HILPDA hypoxia inducible lipid droplet-associated
HK2 hexokinase 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-E major histocompatibility complex, class I, E
HMOX1 heme oxygenase 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER3 immediate early response 3
IGFBP3 insulin-like growth factor binding protein 3
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
KDM3A lysine (K)-specific demethylase 3A
KLHL24 kelch-like family member 24
MARCH6 membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase
MDK midkine (neurite growth-promoting factor 2)
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEF2C myocyte enhancer factor 2C
MGEA5 meningioma expressed antigen 5 (hyaluronidase)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MMP12 matrix metallopeptidase 12
MXI1 MAX interactor 1, dimerization protein
NACA nascent polypeptide-associated complex alpha subunit
NDRG1 N-myc downstream regulated 1
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NELL2 NEL-like 2 (chicken)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NUPR1 nuclear protein, transcriptional regulator, 1
OLFML2A olfactomedin-like 2A
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
PGK1 phosphoglycerate kinase 1
PLD3 phospholipase D family, member 3
PLIN2 perilipin 2
PPAP2B phosphatidic acid phosphatase type 2B
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PRSS21 protease, serine, 21 (testisin)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS1 regulator of G-protein signaling 1
RGS16 regulator of G-protein signaling 16
RHOB ras homolog family member B
SELENBP1 selenium binding protein 1
SEPW1 selenoprotein W, 1
SERTAD2 SERTA domain containing 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC2A5 solute carrier family 2 (facilitated glucose/fructose transporter), member 5
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SNX13 sorting nexin 13
SOD2 superoxide dismutase 2, mitochondrial
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila)
SQSTM1 sequestosome 1
STC1 stanniocalcin 1
TKT transketolase
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNIP1 TNFAIP3 interacting protein 1
TNNC1 troponin C type 1 (slow)
TRD T cell receptor delta locus
TRDV3 T cell receptor delta variable 3
TTN titin
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WSB1 WD repeat and SOCS box containing 1
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACTN1 actinin, alpha 1
AMACR alpha-methylacyl-CoA racemase
BASP1 brain abundant, membrane attached signal protein 1
CCNF cyclin F
CD58 CD58 molecule
CDH2 cadherin 2, type 1, N-cadherin (neuronal)
CKS2 CDC28 protein kinase regulatory subunit 2
CLC Charcot-Leyden crystal galectin
CPB1 carboxypeptidase B1 (tissue)
CPVL carboxypeptidase, vitellogenic-like
CST3 cystatin C
CTSG cathepsin G
CXCL14 chemokine (C-X-C motif) ligand 14
DKK1 dickkopf WNT signaling pathway inhibitor 1
DNAAF2 dynein, axonemal, assembly factor 2
EBAG9 estrogen receptor binding site associated, antigen, 9
F5 coagulation factor V (proaccelerin, labile factor)
HAT1 histone acetyltransferase 1
KANK1 KN motif and ankyrin repeat domains 1
KCNJ16 potassium channel, inwardly rectifying subfamily J, member 16
KHDRBS3 KH domain containing, RNA binding, signal transduction associated 3
KRT10 keratin 10, type I
LYPLA1 lysophospholipase I
MANSC1 MANSC domain containing 1
MARCKS myristoylated alanine-rich protein kinase C substrate
MCUR1 mitochondrial calcium uniporter regulator 1
MGAT2 mannosyl (alpha-1,6-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
MOK MOK protein kinase
MTCL1 microtubule crosslinking factor 1
NMI N-myc (and STAT) interactor
PGRMC2 progesterone receptor membrane component 2
PLAT plasminogen activator, tissue
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRSS23 protease, serine, 23
PTGDS prostaglandin D2 synthase 21kDa (brain)
RANBP6 RAN binding protein 6
RBBP8 retinoblastoma binding protein 8
RMI1 RecQ mediated genome instability 1
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLIRP SRA stem-loop interacting RNA binding protein
SNRPG small nuclear ribonucleoprotein polypeptide G
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPINK1 serine peptidase inhibitor, Kazal type 1
SRPX sushi-repeat containing protein, X-linked
TESC tescalcin
TFPI2 tissue factor pathway inhibitor 2
THBS1 thrombospondin 1
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TM4SF1 transmembrane 4 L six family member 1
TXNDC9 thioredoxin domain containing 9
TYRP1 tyrosinase-related protein 1
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UPK1B uroplakin 1B
VCAN versican