BRD-K01834163_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

182 genes differentially expressed following the BRD-K01834163_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group)
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
ACTN1 actinin, alpha 1
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
AMIGO2 adhesion molecule with Ig-like domain 2
ASPH aspartate beta-hydroxylase
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D
BAG2 BCL2-associated athanogene 2
CALR calreticulin
CBR3 carbonyl reductase 3
CCL5 chemokine (C-C motif) ligand 5
CD36 CD36 molecule (thrombospondin receptor)
CD8A CD8a molecule
CDA cytidine deaminase
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11
CLIC3 chloride intracellular channel 3
CLU clusterin
COTL1 coactosin-like F-actin binding protein 1
CST7 cystatin F (leukocystatin)
CTSL cathepsin L
CTTN cortactin
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DIO2 deiodinase, iodothyronine, type II
DKK1 dickkopf WNT signaling pathway inhibitor 1
DUSP4 dual specificity phosphatase 4
DUSP5 dual specificity phosphatase 5
EGFR epidermal growth factor receptor
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FAM69A family with sequence similarity 69, member A
FOSL1 FOS-like antigen 1
FTH1 ferritin, heavy polypeptide 1
FZD5 frizzled class receptor 5
FZD7 frizzled class receptor 7
G6PD glucose-6-phosphate dehydrogenase
GAL galanin/GMAP prepropeptide
GCLC glutamate-cysteine ligase, catalytic subunit
GCLM glutamate-cysteine ligase, modifier subunit
GLTP glycolipid transfer protein
GPX2 glutathione peroxidase 2
GZMK granzyme K (granzyme 3; tryptase II)
HACD1 3-hydroxyacyl-CoA dehydratase 1
HDGFRP3 hepatoma-derived growth factor, related protein 3
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
HSPB8 heat shock 22kDa protein 8
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
ITGB5 integrin, beta 5
KAZN kazrin, periplakin interacting protein
KRT17 keratin 17, type I
KYNU kynureninase
MAP1B microtubule-associated protein 1B
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MEGF9 multiple EGF-like-domains 9
MFAP3L microfibrillar-associated protein 3-like
MICALL1 MICAL-like 1
NQO1 NAD(P)H dehydrogenase, quinone 1
NSMF NMDA receptor synaptonuclear signaling and neuronal migration factor
PF4 platelet factor 4
PFN2 profilin 2
PGD phosphogluconate dehydrogenase
PI3 peptidase inhibitor 3, skin-derived
PIR pirin (iron-binding nuclear protein)
PLAUR plasminogen activator, urokinase receptor
PPAP2C phosphatidic acid phosphatase type 2C
PRDX1 peroxiredoxin 1
PTGES prostaglandin E synthase
RAP1GAP RAP1 GTPase activating protein
RHOF ras homolog family member F (in filopodia)
RIT1 Ras-like without CAAX 1
RND3 Rho family GTPase 3
RPL37A ribosomal protein L37a
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERPINB5 serpin peptidase inhibitor, clade B (ovalbumin), member 5
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX9 SRY (sex determining region Y)-box 9
SPG20 spastic paraplegia 20 (Troyer syndrome)
SPHK1 sphingosine kinase 1
SQSTM1 sequestosome 1
SYNM synemin, intermediate filament protein
TALDO1 transaldolase 1
TIMP3 TIMP metallopeptidase inhibitor 3
TPM4 tropomyosin 4
TRIM16 tripartite motif containing 16
TSKU tsukushi, small leucine rich proteoglycan
TSPAN3 tetraspanin 3
TUBB2A tubulin, beta 2A class IIa
TXN thioredoxin
TXNRD1 thioredoxin reductase 1
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ANG angiogenin, ribonuclease, RNase A family, 5
ARMCX1 armadillo repeat containing, X-linked 1
ARPP21 cAMP-regulated phosphoprotein, 21kDa
ASRGL1 asparaginase like 1
C10ORF10 chromosome 10 open reading frame 10
C6ORF48 chromosome 6 open reading frame 48
C7 complement component 7
CCNG2 cyclin G2
CDC45 cell division cycle 45
CDK1 cyclin-dependent kinase 1
CDK6 cyclin-dependent kinase 6
CFB complement factor B
CHGB chromogranin B
CLDN3 claudin 3
CLDN7 claudin 7
COL13A1 collagen, type XIII, alpha 1
COL1A2 collagen, type I, alpha 2
COL3A1 collagen, type III, alpha 1
CPE carboxypeptidase E
CTSK cathepsin K
DCN decorin
DPYSL2 dihydropyrimidinase-like 2
EGFL6 EGF-like-domain, multiple 6
ESR1 estrogen receptor 1
FILIP1L filamin A interacting protein 1-like
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GREB1 growth regulation by estrogen in breast cancer 1
HLF hepatic leukemia factor
HMGB2 high mobility group box 2
HNMT histamine N-methyltransferase
IFI27 interferon, alpha-inducible protein 27
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
ISG15 ISG15 ubiquitin-like modifier
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
KRT19 keratin 19, type I
LAMP5 lysosomal-associated membrane protein family, member 5
LEF1 lymphoid enhancer-binding factor 1
LPAR6 lysophosphatidic acid receptor 6
MCM7 minichromosome maintenance complex component 7
MGP matrix Gla protein
MT1E metallothionein 1E
MUC16 mucin 16, cell surface associated
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OSR2 odd-skipped related transciption factor 2
PDGFC platelet derived growth factor C
PEG10 paternally expressed 10
PEG3 paternally expressed 3
POSTN periostin, osteoblast specific factor
PXDN peroxidasin
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2
RGS4 regulator of G-protein signaling 4
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RRM2 ribonucleotide reductase M2
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SPINK1 serine peptidase inhibitor, Kazal type 1
SSBP2 single-stranded DNA binding protein 2
SULF1 sulfatase 1
TACSTD2 tumor-associated calcium signal transducer 2
TFF3 trefoil factor 3 (intestinal)
TFPI2 tissue factor pathway inhibitor 2
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TYMS thymidylate synthetase
VPS28 vacuolar protein sorting 28 homolog (S. cerevisiae)
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2