BRD-K01436366_XMD-1150_MDAMB231_24_h_1.11_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

150 genes differentially expressed following the BRD-K01436366_XMD-1150_MDAMB231_24_h_1.11_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
AAMDC adipogenesis associated, Mth938 domain containing
ACKR3 atypical chemokine receptor 3
ADD3 adducin 3 (gamma)
ANO10 anoctamin 10
AREG amphiregulin
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like
CCDC85B coiled-coil domain containing 85B
CCNG2 cyclin G2
CETN2 centrin, EF-hand protein, 2
CYB5A cytochrome b5 type A (microsomal)
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
EFNB2 ephrin-B2
F11R F11 receptor
FABP4 fatty acid binding protein 4, adipocyte
FAM50A family with sequence similarity 50, member A
FYN FYN proto-oncogene, Src family tyrosine kinase
G6PD glucose-6-phosphate dehydrogenase
GSTM3 glutathione S-transferase mu 3 (brain)
GUK1 guanylate kinase 1
HIST1H1C histone cluster 1, H1c
HIST1H2BC histone cluster 1, H2bc
HIST1H2BK histone cluster 1, H2bk
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
IDS iduronate 2-sulfatase
IFI27 interferon, alpha-inducible protein 27
LAPTM4B lysosomal protein transmembrane 4 beta
LDLR low density lipoprotein receptor
LDOC1 leucine zipper, down-regulated in cancer 1
LGMN legumain
MBNL2 muscleblind-like splicing regulator 2
MIR22HG MIR22 host gene
MLF1 myeloid leukemia factor 1
MSMO1 methylsterol monooxygenase 1
NEU1 sialidase 1 (lysosomal sialidase)
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NSDHL NAD(P) dependent steroid dehydrogenase-like
OSBPL9 oxysterol binding protein-like 9
PCDH17 protocadherin 17
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
REG1A regenerating islet-derived 1 alpha
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SH3BP5 SH3-domain binding protein 5 (BTK-associated)
SPTSSA serine palmitoyltransferase, small subunit A
SQLE squalene epoxidase
STXBP1 syntaxin binding protein 1
SULT1A1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
THBD thrombomodulin
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM14B transmembrane protein 14B
TOB1 transducer of ERBB2, 1
TPST2 tyrosylprotein sulfotransferase 2
TSPYL2 TSPY-like 2
TUBA1A tubulin, alpha 1a

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACTC1 actin, alpha, cardiac muscle 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AZGP1 alpha-2-glycoprotein 1, zinc-binding
BIRC5 baculoviral IAP repeat containing 5
BRCA1 breast cancer 1, early onset
C1R complement component 1, r subcomponent
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAPN2 calpain 2, (m/II) large subunit
CBR3 carbonyl reductase 3
CCDC86 coiled-coil domain containing 86
CCNA2 cyclin A2
CCND2 cyclin D2
CDK1 cyclin-dependent kinase 1
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CHI3L2 chitinase 3-like 2
CLDN8 claudin 8
CRISP3 cysteine-rich secretory protein 3
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
EFS embryonal Fyn-associated substrate
EIF5A eukaryotic translation initiation factor 5A
ELF5 E74-like factor 5 (ets domain transcription factor)
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FABP7 fatty acid binding protein 7, brain
FAM129A family with sequence similarity 129, member A
FANCI Fanconi anemia, complementation group I
FAS Fas cell surface death receptor
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS1 GINS complex subunit 1 (Psf1 homolog)
GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase
GRIA2 glutamate receptor, ionotropic, AMPA 2
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
IGF1 insulin-like growth factor 1 (somatomedin C)
KRT14 keratin 14, type I
KRT17 keratin 17, type I
KRT23 keratin 23, type I
LMNB1 lamin B1
LPAR6 lysophosphatidic acid receptor 6
LTF lactotransferrin
MARCKS myristoylated alanine-rich protein kinase C substrate
MCM5 minichromosome maintenance complex component 5
MELK maternal embryonic leucine zipper kinase
MGP matrix Gla protein
MSMB microseminoprotein, beta-
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYBPC1 myosin binding protein C, slow type
NDC80 NDC80 kinetochore complex component
NKX3-1 NK3 homeobox 1
NMI N-myc (and STAT) interactor
NUSAP1 nucleolar and spindle associated protein 1
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa
PCNA proliferating cell nuclear antigen
PDE4B phosphodiesterase 4B, cAMP-specific
PLAC8 placenta-specific 8
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
POSTN periostin, osteoblast specific factor
PTN pleiotrophin
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
RANBP1 RAN binding protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RPL38 ribosomal protein L38
RRM2 ribonucleotide reductase M2
S100P S100 calcium binding protein P
SCRG1 stimulator of chondrogenesis 1
SDC1 syndecan 1
SEPHS1 selenophosphate synthetase 1
SET SET nuclear proto-oncogene
SFN stratifin
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SNAP25 synaptosomal-associated protein, 25kDa
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SORBS3 sorbin and SH3 domain containing 3
STEAP1 six transmembrane epithelial antigen of the prostate 1
TFAP2C transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
TMPO thymopoietin
TRIB2 tribbles pseudokinase 2
TSPAN8 tetraspanin 8
TXN thioredoxin
UBE2C ubiquitin-conjugating enzyme E2C
VCAN versican
ZEB1 zinc finger E-box binding homeobox 1
ZIC1 Zic family member 1
ZNF22 zinc finger protein 22
ZWINT ZW10 interacting kinetochore protein