BRD-K01436366_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

188 genes differentially expressed following the BRD-K01436366_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALDOC aldolase C, fructose-bisphosphate
AMFR autocrine motility factor receptor, E3 ubiquitin protein ligase
BEX1 brain expressed, X-linked 1
BSG basigin (Ok blood group)
CADM1 cell adhesion molecule 1
CAST calpastatin
CCND2 cyclin D2
CD9 CD9 molecule
CPA3 carboxypeptidase A3 (mast cell)
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like)
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila)
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DSP desmoplakin
DSTN destrin (actin depolymerizing factor)
EPAS1 endothelial PAS domain protein 1
ERBB2 erb-b2 receptor tyrosine kinase 2
FABP4 fatty acid binding protein 4, adipocyte
FAM117A family with sequence similarity 117, member A
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FTH1 ferritin, heavy polypeptide 1
GABBR2 gamma-aminobutyric acid (GABA) B receptor, 2
GNAS GNAS complex locus
GPNMB glycoprotein (transmembrane) nmb
GREM1 gremlin 1, DAN family BMP antagonist
GSN gelsolin
H2BFS H2B histone family, member S (pseudogene)
HIST1H1C histone cluster 1, H1c
HIST1H2AC histone cluster 1, H2ac
HIST1H2AG histone cluster 1, H2ag
HIST1H2BC histone cluster 1, H2bc
HIST1H2BF histone cluster 1, H2bf
HIST1H2BG histone cluster 1, H2bg
HIST1H2BK histone cluster 1, H2bk
HIST1H3H histone cluster 1, H3h
HIST2H2BE histone cluster 2, H2be
HLA-B major histocompatibility complex, class I, B
HOPX HOP homeobox
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
JAG1 jagged 1
KIAA1033 KIAA1033
LRP4 low density lipoprotein receptor-related protein 4
LRPAP1 low density lipoprotein receptor-related protein associated protein 1
LYZ lysozyme
MAB21L2 mab-21-like 2 (C. elegans)
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2
MAPRE2 microtubule-associated protein, RP/EB family, member 2
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
NCAM1 neural cell adhesion molecule 1
NDRG1 N-myc downstream regulated 1
NEBL nebulette
NPTX2 neuronal pentraxin II
PBX3 pre-B-cell leukemia homeobox 3
PCDH9 protocadherin 9
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PRUNE2 prune homolog 2 (Drosophila)
PTGER4 prostaglandin E receptor 4 (subtype EP4)
RGCC regulator of cell cycle
RHOB ras homolog family member B
RPS4Y1 ribosomal protein S4, Y-linked 1
RRBP1 ribosome binding protein 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SIK3 SIK family kinase 3
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SPTAN1 spectrin, alpha, non-erythrocytic 1
SPTSSA serine palmitoyltransferase, small subunit A
STXBP1 syntaxin binding protein 1
TMEM2 transmembrane protein 2
TXNIP thioredoxin interacting protein
UBR4 ubiquitin protein ligase E3 component n-recognin 4
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VCL vinculin
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide
AGR2 anterior gradient 2
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ARMT1 acidic residue methyltransferase 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATF1 activating transcription factor 1
B3GNT1
BDH1 3-hydroxybutyrate dehydrogenase, type 1
BET1 Bet1 golgi vesicular membrane trafficking protein
CCNA2 cyclin A2
CCND1 cyclin D1
CD200 CD200 molecule
CD58 CD58 molecule
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CFB complement factor B
CRABP2 cellular retinoic acid binding protein 2
CXCL12 chemokine (C-X-C motif) ligand 12
CYB561 cytochrome b561
CYR61 cysteine-rich, angiogenic inducer, 61
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
ECT2 epithelial cell transforming 2
ELOVL6 ELOVL fatty acid elongase 6
EMP1 epithelial membrane protein 1
ESR1 estrogen receptor 1
EYA2 EYA transcriptional coactivator and phosphatase 2
F12 coagulation factor XII (Hageman factor)
FHL2 four and a half LIM domains 2
FXYD3 FXYD domain containing ion transport regulator 3
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12
GJA1 gap junction protein, alpha 1, 43kDa
HMGB2 high mobility group box 2
HOMER2 homer scaffolding protein 2
HOXC6 homeobox C6
ICAM3 intercellular adhesion molecule 3
IER3 immediate early response 3
IFITM2 interferon induced transmembrane protein 2
IGF1 insulin-like growth factor 1 (somatomedin C)
IGFBP4 insulin-like growth factor binding protein 4
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIAA0101 KIAA0101
KIF14 kinesin family member 14
KRT19 keratin 19, type I
KYNU kynureninase
LMNB1 lamin B1
LRIG1 leucine-rich repeats and immunoglobulin-like domains 1
LY6E lymphocyte antigen 6 complex, locus E
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MDK midkine (neurite growth-promoting factor 2)
MED21 mediator complex subunit 21
MELK maternal embryonic leucine zipper kinase
MLPH melanophilin
MREG melanoregulin
MUC1 mucin 1, cell surface associated
MUC16 mucin 16, cell surface associated
MYOF myoferlin
NBN nibrin
NEK2 NIMA-related kinase 2
NME4 NME/NM23 nucleoside diphosphate kinase 4
NR2F6 nuclear receptor subfamily 2, group F, member 6
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1
OLFML3 olfactomedin-like 3
PBK PDZ binding kinase
PCOLCE procollagen C-endopeptidase enhancer
PDLIM2 PDZ and LIM domain 2 (mystique)
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPAP2C phosphatidic acid phosphatase type 2C
PPIF peptidylprolyl isomerase F
PRSS23 protease, serine, 23
RAB25 RAB25, member RAS oncogene family
RAD51AP1 RAD51 associated protein 1
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
RFC4 replication factor C (activator 1) 4, 37kDa
RGS10 regulator of G-protein signaling 10
RPS5 ribosomal protein S5
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SERPINB3 serpin peptidase inhibitor, clade B (ovalbumin), member 3
SLC2A4RG SLC2A4 regulator
SLC43A3 solute carrier family 43, member 3
SORBS3 sorbin and SH3 domain containing 3
SORD sorbitol dehydrogenase
SPDEF SAM pointed domain containing ETS transcription factor
SPINK5 serine peptidase inhibitor, Kazal type 5
SPON1 spondin 1, extracellular matrix protein
TACSTD2 tumor-associated calcium signal transducer 2
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TNNT1 troponin T type 1 (skeletal, slow)
TOP2A topoisomerase (DNA) II alpha 170kDa
TPBG trophoblast glycoprotein
TUSC3 tumor suppressor candidate 3
TYMS thymidylate synthetase
UBE2C ubiquitin-conjugating enzyme E2C
WEE1 WEE1 G2 checkpoint kinase
WFDC2 WAP four-disulfide core domain 2
XBP1 X-box binding protein 1
ZWINT ZW10 interacting kinetochore protein