BRD-K01292756_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

91 genes differentially expressed following the BRD-K01292756_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL3 acyl-CoA synthetase long-chain family member 3
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12
ASNS asparagine synthetase (glutamine-hydrolyzing)
CCNG2 cyclin G2
CD24 CD24 molecule
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CLEC11A C-type lectin domain family 11, member A
CLGN calmegin
CPE carboxypeptidase E
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DEPTOR DEP domain containing MTOR-interacting protein
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
ELANE elastase, neutrophil expressed
EMP3 epithelial membrane protein 3
FADS1 fatty acid desaturase 1
FADS2 fatty acid desaturase 2
FAM129A family with sequence similarity 129, member A
FDFT1 farnesyl-diphosphate farnesyltransferase 1
FDPS farnesyl diphosphate synthase
FKBP14 FK506 binding protein 14, 22 kDa
FOS FBJ murine osteosarcoma viral oncogene homolog
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HIST1H2BG histone cluster 1, H2bg
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7
HSPA2 heat shock 70kDa protein 2
IDI1 isopentenyl-diphosphate delta isomerase 1
INSIG1 insulin induced gene 1
IPO13 importin 13
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
LDLR low density lipoprotein receptor
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MAGEA3 melanoma antigen family A3
MAOA monoamine oxidase A
METTL7A methyltransferase like 7A
MKNK2 MAP kinase interacting serine/threonine kinase 2
MSMO1 methylsterol monooxygenase 1
MT1F metallothionein 1F
MT1G metallothionein 1G
MT1HL1 metallothionein 1H-like 1
MT1X metallothionein 1X
MT2A metallothionein 2A
NSDHL NAD(P) dependent steroid dehydrogenase-like
PIR pirin (iron-binding nuclear protein)
PPIC peptidylprolyl isomerase C (cyclophilin C)
PSPH phosphoserine phosphatase
RAB29 RAB29, member RAS oncogene family
RBKS ribokinase
REEP1 receptor accessory protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SQLE squalene epoxidase
SYNE2 spectrin repeat containing, nuclear envelope 2
TECR trans-2,3-enoyl-CoA reductase
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TSC22D3 TSC22 domain family, member 3
ZNF430 zinc finger protein 430
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1
AUTS2 autism susceptibility candidate 2
BTBD3 BTB (POZ) domain containing 3
CA2 carbonic anhydrase II
CELF2 CUGBP, Elav-like family member 2
DCTD dCMP deaminase
DSP desmoplakin
GREB1 growth regulation by estrogen in breast cancer 1
GRWD1 glutamate-rich WD repeat containing 1
IFI44L interferon-induced protein 44-like
KCTD5 potassium channel tetramerization domain containing 5
LPL lipoprotein lipase
MRPS2 mitochondrial ribosomal protein S2
NOP16 NOP16 nucleolar protein
PAPD7 PAP associated domain containing 7
PMM2 phosphomannomutase 2
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SDC2 syndecan 2
SHB Src homology 2 domain containing adaptor protein B
SNX7 sorting nexin 7
TFPI2 tissue factor pathway inhibitor 2
TPD52L1 tumor protein D52-like 1
TSPAN13 tetraspanin 13
TUSC3 tumor suppressor candidate 3