BRD-K01292756_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

77 genes differentially expressed following the BRD-K01292756_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACAT2 acetyl-CoA acetyltransferase 2
ALDOC aldolase C, fructose-bisphosphate
APOLD1 apolipoprotein L domain containing 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARNT2 aryl-hydrocarbon receptor nuclear translocator 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
CBS cystathionine-beta-synthase
CD24 CD24 molecule
CD44 CD44 molecule (Indian blood group)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLIC4 chloride intracellular channel 4
CRABP2 cellular retinoic acid binding protein 2
CXCL9 chemokine (C-X-C motif) ligand 9
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DHCR7 7-dehydrocholesterol reductase
DUSP4 dual specificity phosphatase 4
ELOVL6 ELOVL fatty acid elongase 6
FADS1 fatty acid desaturase 1
FAM117A family with sequence similarity 117, member A
FDPS farnesyl diphosphate synthase
FN1 fibronectin 1
GAS6 growth arrest-specific 6
GDF15 growth differentiation factor 15
GREM1 gremlin 1, DAN family BMP antagonist
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
IER5 immediate early response 5
IGFBP7 insulin-like growth factor binding protein 7
INSIG1 insulin induced gene 1
KCNJ2 potassium channel, inwardly rectifying subfamily J, member 2
LDLR low density lipoprotein receptor
MSMO1 methylsterol monooxygenase 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NT5E 5'-nucleotidase, ecto (CD73)
NUPR1 nuclear protein, transcriptional regulator, 1
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PYCARD PYD and CARD domain containing
RAP1GAP RAP1 GTPase activating protein
RHOB ras homolog family member B
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
RND3 Rho family GTPase 3
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SGK1 serum/glucocorticoid regulated kinase 1
SLC38A2 solute carrier family 38, member 2
SNX13 sorting nexin 13
SQLE squalene epoxidase
THBS2 thrombospondin 2
TLR4 toll-like receptor 4
TRIM2 tripartite motif containing 2
TSC22D3 TSC22 domain family, member 3
VAT1 vesicle amine transport 1
VEGFA vascular endothelial growth factor A

decreased expression

Symbol Name
ADGRL2 adhesion G protein-coupled receptor L2
FEN1 flap structure-specific endonuclease 1
H2AFX H2A histone family, member X
HNRNPM heterogeneous nuclear ribonucleoprotein M
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
KIF20A kinesin family member 20A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
MEIS2 Meis homeobox 2
NR2F1 nuclear receptor subfamily 2, group F, member 1
SDC2 syndecan 2
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
XYLT1 xylosyltransferase I