BRD-K01292756_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

141 genes differentially expressed following the BRD-K01292756_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ATF3 activating transcription factor 3
BGN biglycan
BHLHE40 basic helix-loop-helix family, member e40
BHLHE41 basic helix-loop-helix family, member e41
BTG2 BTG family, member 2
C1QA complement component 1, q subcomponent, A chain
CCNA1 cyclin A1
CD200 CD200 molecule
CHIC2 cysteine-rich hydrophobic domain 2
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CXCR4 chemokine (C-X-C motif) receptor 4
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP1 dual specificity phosphatase 1
EGR1 early growth response 1
EGR3 early growth response 3
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FXYD6 FXYD domain containing ion transport regulator 6
GADD45B growth arrest and DNA-damage-inducible, beta
GEM GTP binding protein overexpressed in skeletal muscle
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HES1 hes family bHLH transcription factor 1
HIST1H2BG histone cluster 1, H2bg
HLA-DPA1 major histocompatibility complex, class II, DP alpha 1
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HSPA1A heat shock 70kDa protein 1A
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPH1 heat shock 105kDa/110kDa protein 1
ICAM1 intercellular adhesion molecule 1
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IER2 immediate early response 2
IER5 immediate early response 5
IGHD immunoglobulin heavy constant delta
IGHM immunoglobulin heavy constant mu
INSR insulin receptor
IRF1 interferon regulatory factor 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KLF10 Kruppel-like factor 10
KRT7 keratin 7, type II
LOC100505650 uncharacterized LOC100505650
LRMP lymphoid-restricted membrane protein
MAP7 microtubule-associated protein 7
MCL1 myeloid cell leukemia 1
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PELI1 pellino E3 ubiquitin protein ligase 1
PLN phospholamban
PNRC1 proline-rich nuclear receptor coactivator 1
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGDS prostaglandin D2 synthase 21kDa (brain)
RGCC regulator of cell cycle
RGS16 regulator of G-protein signaling 16
RGS3 regulator of G-protein signaling 3
RGS5 regulator of G-protein signaling 5
RIPK2 receptor-interacting serine-threonine kinase 2
RRAD Ras-related associated with diabetes
SCGB2A1 secretoglobin, family 2A, member 1
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SIK1 salt-inducible kinase 1
SOX17 SRY (sex determining region Y)-box 17
SPARCL1 SPARC-like 1 (hevin)
SRGN serglycin
SULF1 sulfatase 1
TFPI2 tissue factor pathway inhibitor 2
TGM2 transglutaminase 2
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
VEGFA vascular endothelial growth factor A
VWF von Willebrand factor
WARS tryptophanyl-tRNA synthetase
WFDC1 WAP four-disulfide core domain 1
XIST X inactive specific transcript (non-protein coding)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZFP36L2 ZFP36 ring finger protein-like 2

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ACOT9 acyl-CoA thioesterase 9
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALOX5 arachidonate 5-lipoxygenase
BST2 bone marrow stromal cell antigen 2
C6ORF62 chromosome 6 open reading frame 62
CD59 CD59 molecule, complement regulatory protein
CDC25A cell division cycle 25A
CDC25B cell division cycle 25B
CHPT1 choline phosphotransferase 1
CLDND1 claudin domain containing 1
CYP1A1 cytochrome P450, family 1, subfamily A, polypeptide 1
DCLK1 doublecortin-like kinase 1
DKK1 dickkopf WNT signaling pathway inhibitor 1
ENO1 enolase 1, (alpha)
ERBB3 erb-b2 receptor tyrosine kinase 3
FABP4 fatty acid binding protein 4, adipocyte
FGF13 fibroblast growth factor 13
FHL1 four and a half LIM domains 1
GDE1 glycerophosphodiester phosphodiesterase 1
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLUL glutamate-ammonia ligase
GPX3 glutathione peroxidase 3
HACD1 3-hydroxyacyl-CoA dehydratase 1
HOXC6 homeobox C6
IFITM2 interferon induced transmembrane protein 2
IGFBP6 insulin-like growth factor binding protein 6
LAMC1 laminin, gamma 1 (formerly LAMB2)
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LOX lysyl oxidase
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MET MET proto-oncogene, receptor tyrosine kinase
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3
NPY neuropeptide Y
PGK1 phosphoglycerate kinase 1
PI3 peptidase inhibitor 3, skin-derived
PIP4K2B phosphatidylinositol-5-phosphate 4-kinase, type II, beta
PRDX2 peroxiredoxin 2
PXMP2 peroxisomal membrane protein 2, 22kDa
QDPR quinoid dihydropteridine reductase
RAD23B RAD23 homolog B (S. cerevisiae)
RBPMS RNA binding protein with multiple splicing
RHOA ras homolog family member A
SET SET nuclear proto-oncogene
SLC25A15 solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 15
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPTBN1 spectrin, beta, non-erythrocytic 1
SRSF1 serine/arginine-rich splicing factor 1
STOM stomatin
SYBU syntabulin (syntaxin-interacting)
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TMBIM6 transmembrane BAX inhibitor motif containing 6
TRIM14 tripartite motif containing 14
VAMP3 vesicle-associated membrane protein 3