BRD-K01121114_AT-MLPCN CSC-006_WSUDLCL2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

105 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_WSUDLCL2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALCAM activated leukocyte cell adhesion molecule
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF4 activating transcription factor 4
ATF5 activating transcription factor 5
CA2 carbonic anhydrase II
CARS cysteinyl-tRNA synthetase
CASP10 caspase 10, apoptosis-related cysteine peptidase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCND2 cyclin D2
CD24 CD24 molecule
CDA cytidine deaminase
CEACAM1 carcinoembryonic antigen-related cell adhesion molecule 1 (biliary glycoprotein)
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CELF2 CUGBP, Elav-like family member 2
COL14A1 collagen, type XIV, alpha 1
CP ceruloplasmin (ferroxidase)
CREB3L2 cAMP responsive element binding protein 3-like 2
CREG1 cellular repressor of E1A-stimulated genes 1
CTH cystathionine gamma-lyase
CXCL12 chemokine (C-X-C motif) ligand 12
CXCL14 chemokine (C-X-C motif) ligand 14
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DDIT4 DNA-damage-inducible transcript 4
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HOMER1 homer scaffolding protein 1
IGL immunoglobulin lambda locus
LGALS3 lectin, galactoside-binding, soluble, 3
LGR5 leucine-rich repeat containing G protein-coupled receptor 5
LTF lactotransferrin
MATN2 matrilin 2
MMP7 matrix metallopeptidase 7
NID2 nidogen 2 (osteonidogen)
OLFM4 olfactomedin 4
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PCLO piccolo presynaptic cytomatrix protein
PHYH phytanoyl-CoA 2-hydroxylase
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PLSCR3 phospholipid scramblase 3
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
RNF167 ring finger protein 167
S100P S100 calcium binding protein P
SFRP1 secreted frizzled-related protein 1
SFRP4 secreted frizzled-related protein 4
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4
SLC39A6 solute carrier family 39 (zinc transporter), member 6
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
STC2 stanniocalcin 2
STOM stomatin
STX1A syntaxin 1A (brain)
TOX3 TOX high mobility group box family member 3
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TSPAN8 tetraspanin 8
TUBB2B tubulin, beta 2B class IIb
XBP1 X-box binding protein 1
YARS tyrosyl-tRNA synthetase
YBX3 Y box binding protein 3

decreased expression

Symbol Name
ADA adenosine deaminase
BCL6 B-cell CLL/lymphoma 6
BHLHE40 basic helix-loop-helix family, member e40
CD1E CD1e molecule
CKB creatine kinase, brain
CNPY3 canopy FGF signaling regulator 3
CPA3 carboxypeptidase A3 (mast cell)
CSRP1 cysteine and glycine-rich protein 1
CTNND1 catenin (cadherin-associated protein), delta 1
DCK deoxycytidine kinase
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
GPR183 G protein-coupled receptor 183
IGFBP4 insulin-like growth factor binding protein 4
ITM2C integral membrane protein 2C
KCTD12 potassium channel tetramerization domain containing 12
KLF4 Kruppel-like factor 4 (gut)
LAMP3 lysosomal-associated membrane protein 3
LRRC41 leucine rich repeat containing 41
MAGEA12 melanoma antigen family A12
METRN meteorin, glial cell differentiation regulator
NT5DC2 5'-nucleotidase domain containing 2
PLK1 polo-like kinase 1
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RIN2 Ras and Rab interactor 2
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SFTPA2 surfactant protein A2
SFTPC surfactant protein C
SFTPD surfactant protein D
SGK1 serum/glucocorticoid regulated kinase 1
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SPON1 spondin 1, extracellular matrix protein
SYNPO synaptopodin
TLR4 toll-like receptor 4
TMEM45A transmembrane protein 45A
TPSAB1 tryptase alpha/beta 1