BRD-K01121114_AT-MLPCN CSC-006_U937_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

92 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_U937_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADGRE5 adhesion G protein-coupled receptor E5
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATXN1 ataxin 1
CCR7 chemokine (C-C motif) receptor 7
CD24 CD24 molecule
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast)
CEP57 centrosomal protein 57kDa
CLEC2B C-type lectin domain family 2, member B
COL9A3 collagen, type IX, alpha 3
DAPK1 death-associated protein kinase 1
DDIT4 DNA-damage-inducible transcript 4
FCGBP Fc fragment of IgG binding protein
GNLY granulysin
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
IGFBP3 insulin-like growth factor binding protein 3
IL1R2 interleukin 1 receptor, type II
MYO5C myosin VC
NKG7 natural killer cell granule protein 7
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PPAP2B phosphatidic acid phosphatase type 2B
PRF1 perforin 1 (pore forming protein)
PRUNE2 prune homolog 2 (Drosophila)
PSAT1 phosphoserine aminotransferase 1
PSPH phosphoserine phosphatase
PXDN peroxidasin
RAMP1 receptor (G protein-coupled) activity modifying protein 1
SGPP1 sphingosine-1-phosphate phosphatase 1
SHB Src homology 2 domain containing adaptor protein B
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SMC1A structural maintenance of chromosomes 1A
SNAI2 snail family zinc finger 2
SOCS1 suppressor of cytokine signaling 1
STC2 stanniocalcin 2
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TMEM47 transmembrane protein 47
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
VEGFA vascular endothelial growth factor A
XCL1 chemokine (C motif) ligand 1
YARS tyrosyl-tRNA synthetase

decreased expression

Symbol Name
ARPC1A actin related protein 2/3 complex, subunit 1A, 41kDa
BEX1 brain expressed, X-linked 1
BEX4 brain expressed, X-linked 4
BST2 bone marrow stromal cell antigen 2
C3ORF14 chromosome 3 open reading frame 14
CD36 CD36 molecule (thrombospondin receptor)
CLIC5 chloride intracellular channel 5
CLU clusterin
CRABP2 cellular retinoic acid binding protein 2
CST3 cystatin C
CTSG cathepsin G
DCN decorin
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DSTN destrin (actin depolymerizing factor)
DUSP5 dual specificity phosphatase 5
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
GNAS GNAS complex locus
GRSF1 G-rich RNA sequence binding factor 1
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IFI44L interferon-induced protein 44-like
IGL immunoglobulin lambda locus
INSIG1 insulin induced gene 1
IRS2 insulin receptor substrate 2
JCHAIN joining chain of multimeric IgA and IgM
KRT7 keratin 7, type II
LMO2 LIM domain only 2 (rhombotin-like 1)
MFSD10 major facilitator superfamily domain containing 10
MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)
MSLN mesothelin
MSMO1 methylsterol monooxygenase 1
NPC2 Niemann-Pick disease, type C2
PLAC8 placenta-specific 8
PRAME preferentially expressed antigen in melanoma
PTMA prothymosin, alpha
PTX3 pentraxin 3, long
PVALB parvalbumin
RNASE2 ribonuclease, RNase A family, 2 (liver, eosinophil-derived neurotoxin)
RPN2 ribophorin II
RPS6 ribosomal protein S6
SQLE squalene epoxidase
TES testin LIM domain protein
TM4SF1 transmembrane 4 L six family member 1
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
UBE3C ubiquitin protein ligase E3C
WBP5 WW domain binding protein 5
ZDHHC6 zinc finger, DHHC-type containing 6