BRD-K01121114_AT-MLPCN CSC-006_THP1_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

115 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_THP1_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADAM10 ADAM metallopeptidase domain 10
AMIGO2 adhesion molecule with Ig-like domain 2
AREG amphiregulin
ARL4A ADP-ribosylation factor-like 4A
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
C6ORF62 chromosome 6 open reading frame 62
CARS cysteinyl-tRNA synthetase
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CSTA cystatin A (stefin A)
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DSP desmoplakin
DUSP5 dual specificity phosphatase 5
EIF5 eukaryotic translation initiation factor 5
EREG epiregulin
EZR ezrin
FBN2 fibrillin 2
FOXO3 forkhead box O3
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GARS glycyl-tRNA synthetase
GDF15 growth differentiation factor 15
GSE1 Gse1 coiled-coil protein
GULP1 GULP, engulfment adaptor PTB domain containing 1
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HEY1 hes-related family bHLH transcription factor with YRPW motif 1
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HSPA13 heat shock protein 70kDa family, member 13
IARS isoleucyl-tRNA synthetase
IFRD1 interferon-related developmental regulator 1
INHBE inhibin, beta E
JMJD1C jumonji domain containing 1C
KLF4 Kruppel-like factor 4 (gut)
KRT18 keratin 18, type I
LGALS3 lectin, galactoside-binding, soluble, 3
MARS methionyl-tRNA synthetase
MCL1 myeloid cell leukemia 1
MTMR11 myotubularin related protein 11
NFIL3 nuclear factor, interleukin 3 regulated
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PHIP pleckstrin homology domain interacting protein
PHLDA1 pleckstrin homology-like domain, family A, member 1
PHLDA2 pleckstrin homology-like domain, family A, member 2
PSAT1 phosphoserine aminotransferase 1
RAB31 RAB31, member RAS oncogene family
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RGS13 regulator of G-protein signaling 13
SARS seryl-tRNA synthetase
SCGB2A2 secretoglobin, family 2A, member 2
SEC14L1 SEC14-like 1 (S. cerevisiae)
SENP6 SUMO1/sentrin specific peptidase 6
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4
SLC38A1 solute carrier family 38, member 1
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
STC2 stanniocalcin 2
SULF1 sulfatase 1
SULT1C2 sulfotransferase family, cytosolic, 1C, member 2
TFRC transferrin receptor
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TUFT1 tuftelin 1
UPP1 uridine phosphorylase 1
VEGFA vascular endothelial growth factor A
VLDLR very low density lipoprotein receptor
WARS tryptophanyl-tRNA synthetase
XBP1 X-box binding protein 1
XPOT exportin, tRNA
ZCCHC8 zinc finger, CCHC domain containing 8
ZNF451 zinc finger protein 451

decreased expression

Symbol Name
ANGPT1 angiopoietin 1
AQP3 aquaporin 3 (Gill blood group)
ATP5E ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
CDK2AP1 cyclin-dependent kinase 2 associated protein 1
CERK ceramide kinase
CORO1B coronin, actin binding protein, 1B
COX7B cytochrome c oxidase subunit VIIb
CRELD2 cysteine-rich with EGF-like domains 2
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CTSB cathepsin B
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
F13A1 coagulation factor XIII, A1 polypeptide
GGH gamma-glutamyl hydrolase (conjugase, folylpolygammaglutamyl hydrolase)
GLIPR1 GLI pathogenesis-related 1
GNAS GNAS complex locus
HN1L hematological and neurological expressed 1-like
HSPA8 heat shock 70kDa protein 8
HSPH1 heat shock 105kDa/110kDa protein 1
INSIG1 insulin induced gene 1
KLK11 kallikrein-related peptidase 11
LSS lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase)
MBOAT7 membrane bound O-acyltransferase domain containing 7
NPC2 Niemann-Pick disease, type C2
PLTP phospholipid transfer protein
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PRKCA protein kinase C, alpha
RPN2 ribophorin II
RUNX1 runt-related transcription factor 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SORD sorbitol dehydrogenase
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM97 transmembrane protein 97