BRD-K01121114_AT-MLPCN CSC-006_PC3_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

336 genes differentially expressed following the BRD-K01121114_AT-MLPCN CSC-006_PC3_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADGRG1 adhesion G protein-coupled receptor G1
ALAS1 5'-aminolevulinate synthase 1
AMIGO2 adhesion molecule with Ig-like domain 2
ARFGAP3 ADP-ribosylation factor GTPase activating protein 3
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ARMCX3 armadillo repeat containing, X-linked 3
ARMCX6 armadillo repeat containing, X-linked 6
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
BTG1 B-cell translocation gene 1, anti-proliferative
C6ORF48 chromosome 6 open reading frame 48
CARS cysteinyl-tRNA synthetase
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CBS cystathionine-beta-synthase
CCL20 chemokine (C-C motif) ligand 20
CCNB1IP1 cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
CCPG1 cell cycle progression 1
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CDK2AP2 cyclin-dependent kinase 2 associated protein 2
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CEBPG CCAAT/enhancer binding protein (C/EBP), gamma
CEMIP cell migration inducing protein, hyaluronan binding
CLDN3 claudin 3
CTH cystathionine gamma-lyase
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL2 chemokine (C-X-C motif) ligand 2
CXCL3 chemokine (C-X-C motif) ligand 3
CXCL5 chemokine (C-X-C motif) ligand 5
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DENND1B DENN/MADD domain containing 1B
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3
EGFR epidermal growth factor receptor
EIF1 eukaryotic translation initiation factor 1
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
ELL2 elongation factor, RNA polymerase II, 2
EPRS glutamyl-prolyl-tRNA synthetase
FAM129A family with sequence similarity 129, member A
FBN2 fibrillin 2
FKBP11 FK506 binding protein 11, 19 kDa
FYN FYN proto-oncogene, Src family tyrosine kinase
GADD45A growth arrest and DNA-damage-inducible, alpha
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GAREM GRB2 associated, regulator of MAPK1
GARS glycyl-tRNA synthetase
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GORASP2 golgi reassembly stacking protein 2, 55kDa
GOT1 glutamic-oxaloacetic transaminase 1, soluble
GRB10 growth factor receptor-bound protein 10
GSAP gamma-secretase activating protein
GTPBP2 GTP binding protein 2
GULP1 GULP, engulfment adaptor PTB domain containing 1
HAX1 HCLS1 associated protein X-1
HMOX1 heme oxygenase 1
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1
HSPA13 heat shock protein 70kDa family, member 13
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HYOU1 hypoxia up-regulated 1
IER3 immediate early response 3
IFI27 interferon, alpha-inducible protein 27
IFRD1 interferon-related developmental regulator 1
IGFBP3 insulin-like growth factor binding protein 3
IL1A interleukin 1, alpha
IL1B interleukin 1, beta
IL1R1 interleukin 1 receptor, type I
IL6 interleukin 6
IL7R interleukin 7 receptor
INHBA inhibin, beta A
INSIG1 insulin induced gene 1
IRF9 interferon regulatory factor 9
ISG20 interferon stimulated exonuclease gene 20kDa
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2
KDELR3 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 3
KLF4 Kruppel-like factor 4 (gut)
KLF5 Kruppel-like factor 5 (intestinal)
KRT23 keratin 23, type I
LAMB3 laminin, beta 3
LAMC2 laminin, gamma 2
LARP6 La ribonucleoprotein domain family, member 6
LGALS4 lectin, galactoside-binding, soluble, 4
LIF leukemia inhibitory factor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MANF mesencephalic astrocyte-derived neurotrophic factor
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MARS methionyl-tRNA synthetase
MIR22HG MIR22 host gene
MKNK2 MAP kinase interacting serine/threonine kinase 2
MMP19 matrix metallopeptidase 19
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO6 myosin VI
NCOA3 nuclear receptor coactivator 3
NFIL3 nuclear factor, interleukin 3 regulated
NIT1 nitrilase 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NUCB2 nucleobindin 2
NUPR1 nuclear protein, transcriptional regulator, 1
OGT O-linked N-acetylglucosamine (GlcNAc) transferase
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial)
PDGFA platelet-derived growth factor alpha polypeptide
PDGFC platelet derived growth factor C
PDIA4 protein disulfide isomerase family A, member 4
PDIA5 protein disulfide isomerase family A, member 5
PHGDH phosphoglycerate dehydrogenase
PHLDA1 pleckstrin homology-like domain, family A, member 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PNRC1 proline-rich nuclear receptor coactivator 1
POLD4 polymerase (DNA-directed), delta 4, accessory subunit
POLR1D polymerase (RNA) I polypeptide D, 16kDa
PPIB peptidylprolyl isomerase B (cyclophilin B)
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSAT1 phosphoserine aminotransferase 1
PTP4A1 protein tyrosine phosphatase type IVA, member 1
PTPN12 protein tyrosine phosphatase, non-receptor type 12
PTX3 pentraxin 3, long
PYCR1 pyrroline-5-carboxylate reductase 1
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2
RBKS ribokinase
RCAN1 regulator of calcineurin 1
RIOK3 RIO kinase 3
RNF19B ring finger protein 19B
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SDF2L1 stromal cell-derived factor 2-like 1
SEC24D SEC24 family member D
SEC61G Sec61 gamma subunit
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
SERINC5 serine incorporator 5
SERP1 stress-associated endoplasmic reticulum protein 1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1
SH3YL1 SH3 and SYLF domain containing 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC1A5 solute carrier family 1 (neutral amino acid transporter), member 5
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1
SLC38A2 solute carrier family 38, member 2
SLC39A14 solute carrier family 39 (zinc transporter), member 14
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SSR2 signal sequence receptor, beta (translocon-associated protein beta)
SSR4 signal sequence receptor, delta
SUCO SUN domain containing ossification factor
TARS threonyl-tRNA synthetase
TCEA1 transcription elongation factor A (SII), 1
TGIF1 TGFB-induced factor homeobox 1
THBD thrombomodulin
TMEM39A transmembrane protein 39A
TNFAIP6 tumor necrosis factor, alpha-induced protein 6
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b
TOM1L1 target of myb1 (chicken)-like 1
TRIB3 tribbles pseudokinase 3
TSC22D3 TSC22 domain family, member 3
TTC17 tetratricopeptide repeat domain 17
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1
UFM1 ubiquitin-fold modifier 1
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
USO1 USO1 vesicle transport factor
VEGFA vascular endothelial growth factor A
WARS tryptophanyl-tRNA synthetase
WDR45 WD repeat domain 45
WIPI1 WD repeat domain, phosphoinositide interacting 1
WNK1 WNK lysine deficient protein kinase 1
XBP1 X-box binding protein 1
XPOT exportin, tRNA
YARS tyrosyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZC3H12A zinc finger CCCH-type containing 12A
ZFP36 ZFP36 ring finger protein
ZNF91 zinc finger protein 91

decreased expression

Symbol Name
A2M alpha-2-macroglobulin
AIM1 absent in melanoma 1
AK4 adenylate kinase 4
ALDH1A2 aldehyde dehydrogenase 1 family, member A2
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ASF1B anti-silencing function 1B histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ATAD2 ATPase family, AAA domain containing 2
ATF5 activating transcription factor 5
AURKB aurora kinase B
B3GNT1
BIRC5 baculoviral IAP repeat containing 5
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C20ORF27 chromosome 20 open reading frame 27
CAV1 caveolin 1, caveolae protein, 22kDa
CBR3 carbonyl reductase 3
CCNA2 cyclin A2
CCND1 cyclin D1
CCND3 cyclin D3
CCNE2 cyclin E2
CD44 CD44 molecule (Indian blood group)
CDC25A cell division cycle 25A
CDCA4 cell division cycle associated 4
CDK1 cyclin-dependent kinase 1
CDK2 cyclin-dependent kinase 2
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CDT1 chromatin licensing and DNA replication factor 1
CENPF centromere protein F, 350/400kDa
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CHEK1 checkpoint kinase 1
CKB creatine kinase, brain
CLEC2B C-type lectin domain family 2, member B
COL6A2 collagen, type VI, alpha 2
CPVL carboxypeptidase, vitellogenic-like
CRYZ crystallin, zeta (quinone reductase)
CSE1L CSE1 chromosome segregation 1-like (yeast)
CXCL11 chemokine (C-X-C motif) ligand 11
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DHFR dihydrofolate reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAJC9 DnaJ (Hsp40) homolog, subfamily C, member 9
DNM1 dynamin 1
DNMT1 DNA (cytosine-5-)-methyltransferase 1
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
ENO1 enolase 1, (alpha)
FAM162A family with sequence similarity 162, member A
FASN fatty acid synthase
FEN1 flap structure-specific endonuclease 1
FHL1 four and a half LIM domains 1
FN1 fibronectin 1
FOXM1 forkhead box M1
GAL galanin/GMAP prepropeptide
GBP1 guanylate binding protein 1, interferon-inducible
GINS1 GINS complex subunit 1 (Psf1 homolog)
GINS2 GINS complex subunit 2 (Psf2 homolog)
GMNN geminin, DNA replication inhibitor
GPI glucose-6-phosphate isomerase
H2AFX H2A histone family, member X
HADH hydroxyacyl-CoA dehydrogenase
HELLS helicase, lymphoid-specific
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1
HOXA10 homeobox A10
ICMT isoprenylcysteine carboxyl methyltransferase
KIAA0101 KIAA0101
KIF11 kinesin family member 11
KIF20A kinesin family member 20A
LAMB1 laminin, beta 1
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LIG1 ligase I, DNA, ATP-dependent
LMNB1 lamin B1
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MATN2 matrilin 2
MCAM melanoma cell adhesion molecule
MCM10 minichromosome maintenance complex component 10
MCM2 minichromosome maintenance complex component 2
MCM3 minichromosome maintenance complex component 3
MCM4 minichromosome maintenance complex component 4
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
MCM7 minichromosome maintenance complex component 7
MKI67 marker of proliferation Ki-67
MSH2 mutS homolog 2
MSH6 mutS homolog 6
MTHFD1 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1, methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2
MYH11 myosin, heavy chain 11, smooth muscle
NASP nuclear autoantigenic sperm protein (histone-binding)
NBL1 neuroblastoma 1, DAN family BMP antagonist
NCAPD3 non-SMC condensin II complex, subunit D3
NCAPH non-SMC condensin I complex, subunit H
NME4 NME/NM23 nucleoside diphosphate kinase 4
NMU neuromedin U
NOP56 NOP56 ribonucleoprotein
NR2F1 nuclear receptor subfamily 2, group F, member 1
NREP neuronal regeneration related protein
NUSAP1 nucleolar and spindle associated protein 1
OAT ornithine aminotransferase
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PCP4 Purkinje cell protein 4
PFKP phosphofructokinase, platelet
PGAM1 phosphoglycerate mutase 1 (brain)
PGK1 phosphoglycerate kinase 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPIF peptidylprolyl isomerase F
PRC1 protein regulator of cytokinesis 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
RAD54B RAD54 homolog B (S. cerevisiae)
REEP1 receptor accessory protein 1
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SFRP1 secreted frizzled-related protein 1
SKP2 S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
SLBP stem-loop binding protein
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3
SLC29A1 solute carrier family 29 (equilibrative nucleoside transporter), member 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SNRPB small nuclear ribonucleoprotein polypeptides B and B1
SNX10 sorting nexin 10
SORD sorbitol dehydrogenase
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
STMN1 stathmin 1
SUMO3 small ubiquitin-like modifier 3
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNM synemin, intermediate filament protein
TACC3 transforming, acidic coiled-coil containing protein 3
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFDP1 transcription factor Dp-1
TGM2 transglutaminase 2
TK1 thymidine kinase 1, soluble
TMEM158 transmembrane protein 158 (gene/pseudogene)
TRIP13 thyroid hormone receptor interactor 13
TUBB tubulin, beta class I
TUBB4B tubulin, beta 4B class IVb
TYMS thymidylate synthetase
UNG uracil-DNA glycosylase
VCAN versican
VCL vinculin
VRK1 vaccinia related kinase 1
WWTR1 WW domain containing transcription regulator 1
ZWINT ZW10 interacting kinetochore protein