BRD-K00954209_7643453_HA1E_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

162 genes differentially expressed following the BRD-K00954209_7643453_HA1E_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
A2M alpha-2-macroglobulin
ALB albumin
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein)
BID BH3 interacting domain death agonist
BLNK B-cell linker
BZW2 basic leucine zipper and W2 domains 2
C10ORF10 chromosome 10 open reading frame 10
CLU clusterin
CP ceruloplasmin (ferroxidase)
CPB1 carboxypeptidase B1 (tissue)
CXCL13 chemokine (C-X-C motif) ligand 13
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
DAXX death-domain associated protein
DEPTOR DEP domain containing MTOR-interacting protein
EPAS1 endothelial PAS domain protein 1
ERBB4 erb-b2 receptor tyrosine kinase 4
FARP1 FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
FGFR2 fibroblast growth factor receptor 2
FGFR3 fibroblast growth factor receptor 3
FZD5 frizzled class receptor 5
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GUSBP11 glucuronidase, beta pseudogene 11
HHEX hematopoietically expressed homeobox
HSD17B6 hydroxysteroid (17-beta) dehydrogenase 6
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
IGL immunoglobulin lambda locus
IGLL3P immunoglobulin lambda-like polypeptide 3, pseudogene
IQGAP1 IQ motif containing GTPase activating protein 1
LMO3 LIM domain only 3 (rhombotin-like 2)
LYZ lysozyme
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MAPKAPK3 mitogen-activated protein kinase-activated protein kinase 3
MEF2C myocyte enhancer factor 2C
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MSMB microseminoprotein, beta-
MYBL1 v-myb avian myeloblastosis viral oncogene homolog-like 1
MYO5C myosin VC
MZB1 marginal zone B and B1 cell-specific protein
NEBL nebulette
NGRN neugrin, neurite outgrowth associated
NREP neuronal regeneration related protein
NRGN neurogranin (protein kinase C substrate, RC3)
PHKA1 phosphorylase kinase, alpha 1 (muscle)
PRR15L proline rich 15-like
RAD51C RAD51 paralog C
RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5
RHOB ras homolog family member B
RNF128 ring finger protein 128, E3 ubiquitin protein ligase
S100A8 S100 calcium binding protein A8
SCGB1A1 secretoglobin, family 1A, member 1 (uteroglobin)
SERINC5 serine incorporator 5
SH3BGRL SH3 domain binding glutamate-rich protein like
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3
SMARCA1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1
SMC1A structural maintenance of chromosomes 1A
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A
SNCA synuclein, alpha (non A4 component of amyloid precursor)
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPARCL1 SPARC-like 1 (hevin)
STAR steroidogenic acute regulatory protein
TBC1D9B TBC1 domain family, member 9B (with GRAM domain)
TMEM110 transmembrane protein 110
TMEM30B transmembrane protein 30B
TSPAN13 tetraspanin 13
VTCN1 V-set domain containing T cell activation inhibitor 1
XIST X inactive specific transcript (non-protein coding)
ZBTB16 zinc finger and BTB domain containing 16

decreased expression

Symbol Name
ACLY ATP citrate lyase
ACOT9 acyl-CoA thioesterase 9
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AK1 adenylate kinase 1
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANK2 ankyrin 2, neuronal
ANXA3 annexin A3
ANXA5 annexin A5
AP1S2 adaptor-related protein complex 1, sigma 2 subunit
BASP1 brain abundant, membrane attached signal protein 1
BEX1 brain expressed, X-linked 1
BIN1 bridging integrator 1
BST2 bone marrow stromal cell antigen 2
CAST calpastatin
CBR3 carbonyl reductase 3
CCDC92 coiled-coil domain containing 92
CCND1 cyclin D1
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CTSK cathepsin K
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL14 chemokine (C-X-C motif) ligand 14
CXCL8 chemokine (C-X-C motif) ligand 8
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DLC1 DLC1 Rho GTPase activating protein
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF4E eukaryotic translation initiation factor 4E
EMP3 epithelial membrane protein 3
EPN2 epsin 2
EVL Enah/Vasp-like
FBLN1 fibulin 1
FXYD3 FXYD domain containing ion transport regulator 3
GAS1 growth arrest-specific 1
HOXB7 homeobox B7
HSPA8 heat shock 70kDa protein 8
IFRD2 interferon-related developmental regulator 2
IGFBP4 insulin-like growth factor binding protein 4
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3
KAZN kazrin, periplakin interacting protein
KDM5D lysine (K)-specific demethylase 5D
KRT7 keratin 7, type II
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein
LITAF lipopolysaccharide-induced TNF factor
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MARCKS myristoylated alanine-rich protein kinase C substrate
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MPRIP myosin phosphatase Rho interacting protein
MSX1 msh homeobox 1
MTA1 metastasis associated 1
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
OAT ornithine aminotransferase
OLFML3 olfactomedin-like 3
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM4 PDZ and LIM domain 4
PKM pyruvate kinase, muscle
PLAT plasminogen activator, tissue
PNMA2 paraneoplastic Ma antigen 2
PNP purine nucleoside phosphorylase
PRR7 proline rich 7 (synaptic)
PSD3 pleckstrin and Sec7 domain containing 3
PTGES prostaglandin E synthase
RNF114 ring finger protein 114
RPL27A ribosomal protein L27a
RPL38 ribosomal protein L38
RPLP2 ribosomal protein, large, P2
RPS11 ribosomal protein S11
RPS4Y1 ribosomal protein S4, Y-linked 1
S100A2 S100 calcium binding protein A2
S100A6 S100 calcium binding protein A6
S100A7 S100 calcium binding protein A7
SFRP1 secreted frizzled-related protein 1
SLC7A1 solute carrier family 7 (cationic amino acid transporter, y+ system), member 1
SLIRP SRA stem-loop interacting RNA binding protein
SRC SRC proto-oncogene, non-receptor tyrosine kinase
SRPX sushi-repeat containing protein, X-linked
TCN1 transcobalamin I (vitamin B12 binding protein, R binder family)
TNFAIP2 tumor necrosis factor, alpha-induced protein 2
TNFAIP8 tumor necrosis factor, alpha-induced protein 8
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TNIP1 TNFAIP3 interacting protein 1
TSPO translocator protein (18kDa)
TUBB2B tubulin, beta 2B class IIb
TXNIP thioredoxin interacting protein
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAT1 vesicle amine transport 1
ZBTB18 zinc finger and BTB domain containing 18
ZCCHC24 zinc finger, CCHC domain containing 24