BRD-K00910650_NCGC00242335-01_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

236 genes differentially expressed following the BRD-K00910650_NCGC00242335-01_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AARS alanyl-tRNA synthetase
ABHD4 abhydrolase domain containing 4
ADM adrenomedullin
AKR1B10 aldo-keto reductase family 1, member B10 (aldose reductase)
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATF4 activating transcription factor 4
ATP6V1C1 ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C1
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1
BAG3 BCL2-associated athanogene 3
C5AR1 complement component 5a receptor 1
CADM1 cell adhesion molecule 1
CD52 CD52 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CEBPB CCAAT/enhancer binding protein (C/EBP), beta
CHIC2 cysteine-rich hydrophobic domain 2
CHMP1B charged multivesicular body protein 1B
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1
COL15A1 collagen, type XV, alpha 1
CRISPLD2 cysteine-rich secretory protein LCCL domain containing 2
CTH cystathionine gamma-lyase
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DIO2 deiodinase, iodothyronine, type II
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4
DNAJB9 DnaJ (Hsp40) homolog, subfamily B, member 9
DNAJC6 DnaJ (Hsp40) homolog, subfamily C, member 6
DNTTIP2 deoxynucleotidyltransferase, terminal, interacting protein 2
DUSP1 dual specificity phosphatase 1
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
EGR1 early growth response 1
ERP44 endoplasmic reticulum protein 44
F2RL1 coagulation factor II (thrombin) receptor-like 1
FAM129A family with sequence similarity 129, member A
FOS FBJ murine osteosarcoma viral oncogene homolog
FOSL1 FOS-like antigen 1
FOXO3 forkhead box O3
FTH1 ferritin, heavy polypeptide 1
GABPB1 GA binding protein transcription factor, beta subunit 1
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GARS glycyl-tRNA synthetase
GCLM glutamate-cysteine ligase, modifier subunit
GEM GTP binding protein overexpressed in skeletal muscle
GFPT1 glutamine--fructose-6-phosphate transaminase 1
GHITM growth hormone inducible transmembrane protein
HBEGF heparin-binding EGF-like growth factor
HBP1 HMG-box transcription factor 1
HCAR3 hydroxycarboxylic acid receptor 3
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
HMOX1 heme oxygenase 1
HPSE heparanase
HSPA1A heat shock 70kDa protein 1A
HSPA4L heat shock 70kDa protein 4-like
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPA8 heat shock 70kDa protein 8
HSPD1 heat shock 60kDa protein 1 (chaperonin)
HSPH1 heat shock 105kDa/110kDa protein 1
HTATIP2 HIV-1 Tat interactive protein 2, 30kDa
IER5 immediate early response 5
IFRD1 interferon-related developmental regulator 1
IL7R interleukin 7 receptor
INHBE inhibin, beta E
ISG20 interferon stimulated exonuclease gene 20kDa
ITGBL1 integrin, beta-like 1 (with EGF-like repeat domains)
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KCTD5 potassium channel tetramerization domain containing 5
KDM6B lysine (K)-specific demethylase 6B
KLF4 Kruppel-like factor 4 (gut)
KLHL24 kelch-like family member 24
KRT18 keratin 18, type I
KRT6A keratin 6A, type II
KRT6B keratin 6B, type II
KYNU kynureninase
LAMP2 lysosomal-associated membrane protein 2
LBH limb bud and heart development
LDLR low density lipoprotein receptor
LIMCH1 LIM and calponin homology domains 1
LRP10 low density lipoprotein receptor-related protein 10
LTBP2 latent transforming growth factor beta binding protein 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAGEB2 melanoma antigen family B2
MAP1B microtubule-associated protein 1B
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MBNL2 muscleblind-like splicing regulator 2
MCL1 myeloid cell leukemia 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
ME2 malic enzyme 2, NAD(+)-dependent, mitochondrial
MIR22HG MIR22 host gene
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MYO1B myosin IB
NAMPT nicotinamide phosphoribosyltransferase
NEBL nebulette
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1
NPC1 Niemann-Pick disease, type C1
NPL N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
ODC1 ornithine decarboxylase 1
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II
PELI1 pellino E3 ubiquitin protein ligase 1
PGC progastricsin (pepsinogen C)
PKP1 plakophilin 1
PMP22 peripheral myelin protein 22
POPDC3 popeye domain containing 3
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PSEN1 presenilin 1
PTPRO protein tyrosine phosphatase, receptor type, O
PTX3 pentraxin 3, long
QPCT glutaminyl-peptide cyclotransferase
RB1CC1 RB1-inducible coiled-coil 1
RGCC regulator of cell cycle
RHOQ ras homolog family member Q
RND3 Rho family GTPase 3
S100A12 S100 calcium binding protein A12
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1)
SFN stratifin
SFTPB surfactant protein B
SGK1 serum/glucocorticoid regulated kinase 1
SH3GLB1 SH3-domain GRB2-like endophilin B1
SIK1 salt-inducible kinase 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SLC3A2 solute carrier family 3 (amino acid transporter heavy chain), member 2
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SPAG9 sperm associated antigen 9
SPRR1A small proline-rich protein 1A
SPRR3 small proline-rich protein 3
SQSTM1 sequestosome 1
STC2 stanniocalcin 2
TBPL1 TBP-like 1
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
TGFBI transforming growth factor, beta-induced, 68kDa
THBD thrombomodulin
TM4SF1 transmembrane 4 L six family member 1
TMBIM6 transmembrane BAX inhibitor motif containing 6
TMED5 transmembrane emp24 protein transport domain containing 5
TPD52 tumor protein D52
TPD52L2 tumor protein D52-like 2
TREM1 triggering receptor expressed on myeloid cells 1
TRIB3 tribbles pseudokinase 3
TXNRD1 thioredoxin reductase 1
TYMP thymidine phosphorylase
UBR4 ubiquitin protein ligase E3 component n-recognin 4
UGDH UDP-glucose 6-dehydrogenase
UPP1 uridine phosphorylase 1
WARS tryptophanyl-tRNA synthetase
YPEL5 yippee-like 5 (Drosophila)
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ACACB acetyl-CoA carboxylase beta
ACSF2 acyl-CoA synthetase family member 2
ACTG2 actin, gamma 2, smooth muscle, enteric
ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide
ADIRF adipogenesis regulatory factor
AIM1 absent in melanoma 1
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta
ATP5I ATP synthase, H+ transporting, mitochondrial Fo complex, subunit E
BMP4 bone morphogenetic protein 4
BST2 bone marrow stromal cell antigen 2
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CDC20 cell division cycle 20
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney)
CDK1 cyclin-dependent kinase 1
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CFB complement factor B
CHL1 cell adhesion molecule L1-like
CHRDL1 chordin-like 1
CP ceruloplasmin (ferroxidase)
CTSG cathepsin G
CXCL12 chemokine (C-X-C motif) ligand 12
DHRS11 dehydrogenase/reductase (SDR family) member 11
DUT deoxyuridine triphosphatase
EBP emopamil binding protein (sterol isomerase)
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
FCGBP Fc fragment of IgG binding protein
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FRZB frizzled-related protein
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase)
GOLGA8H golgin A8 family, member H
GPRC5B G protein-coupled receptor, class C, group 5, member B
GPX3 glutathione peroxidase 3
HLF hepatic leukemia factor
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IFIT1 interferon-induced protein with tetratricopeptide repeats 1
IFITM1 interferon induced transmembrane protein 1
IFITM2 interferon induced transmembrane protein 2
IFITM3 interferon induced transmembrane protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGB1BP1 integrin beta 1 binding protein 1
LOC100505650 uncharacterized LOC100505650
LSM5 LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
MAOB monoamine oxidase B
MAP4K1 mitogen-activated protein kinase kinase kinase kinase 1
MEIS1 Meis homeobox 1
MXRA5 matrix-remodelling associated 5
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NPTX1 neuronal pentraxin I
NR2F2 nuclear receptor subfamily 2, group F, member 2
NREP neuronal regeneration related protein
NRN1 neuritin 1
PCNA proliferating cell nuclear antigen
PLIN1 perilipin 1
PON2 paraoxonase 2
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PROM1 prominin 1
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8
PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)
PXMP2 peroxisomal membrane protein 2, 22kDa
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RGS1 regulator of G-protein signaling 1
RUNX3 runt-related transcription factor 3
SELENBP1 selenium binding protein 1
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC4A4 solute carrier family 4 (sodium bicarbonate cotransporter), member 4
SORBS3 sorbin and SH3 domain containing 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SOX4 SRY (sex determining region Y)-box 4
ST6GAL1 ST6 beta-galactosamide alpha-2,6-sialyltranferase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TFPI2 tissue factor pathway inhibitor 2
TNS3 tensin 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TUBB tubulin, beta class I
VTCN1 V-set domain containing T cell activation inhibitor 1
WFDC2 WAP four-disulfide core domain 2