BRD-K00824317_-666_A549_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

102 genes differentially expressed following the BRD-K00824317_-666_A549_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACSL1 acyl-CoA synthetase long-chain family member 1
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1
AIM1 absent in melanoma 1
ALCAM activated leukocyte cell adhesion molecule
AQP3 aquaporin 3 (Gill blood group)
AREG amphiregulin
C10ORF10 chromosome 10 open reading frame 10
CDK19 cyclin-dependent kinase 19
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CEBPD CCAAT/enhancer binding protein (C/EBP), delta
CP ceruloplasmin (ferroxidase)
CPM carboxypeptidase M
CRIP1 cysteine-rich protein 1 (intestinal)
CRIP2 cysteine-rich protein 2
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein)
DDIT4 DNA-damage-inducible transcript 4
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
DUSP1 dual specificity phosphatase 1
EMP1 epithelial membrane protein 1
EVL Enah/Vasp-like
F13A1 coagulation factor XIII, A1 polypeptide
F3 coagulation factor III (thromboplastin, tissue factor)
FGG fibrinogen gamma chain
FKBP5 FK506 binding protein 5
FOSB FBJ murine osteosarcoma viral oncogene homolog B
GADD45B growth arrest and DNA-damage-inducible, beta
GLRX glutaredoxin (thioltransferase)
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
KBTBD11 kelch repeat and BTB (POZ) domain containing 11
KDM5D lysine (K)-specific demethylase 5D
KLF6 Kruppel-like factor 6
KLF9 Kruppel-like factor 9
KRT14 keratin 14, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
MALL mal, T-cell differentiation protein-like
MAOA monoamine oxidase A
MAPT microtubule-associated protein tau
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain)
PDK4 pyruvate dehydrogenase kinase, isozyme 4
PER1 period circadian clock 1
PPL periplakin
PRKCD protein kinase C, delta
RGS2 regulator of G-protein signaling 2
S100A2 S100 calcium binding protein A2
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SFN stratifin
SPEN spen family transcriptional repressor
SYBU syntabulin (syntaxin-interacting)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TYRP1 tyrosinase-related protein 1
ZBTB16 zinc finger and BTB domain containing 16
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
ALOX5AP arachidonate 5-lipoxygenase-activating protein
BLNK B-cell linker
BMP2 bone morphogenetic protein 2
C6ORF62 chromosome 6 open reading frame 62
CCL2 chemokine (C-C motif) ligand 2
CCL8 chemokine (C-C motif) ligand 8
CLU clusterin
CRISP3 cysteine-rich secretory protein 3
CXCL11 chemokine (C-X-C motif) ligand 11
CXCL13 chemokine (C-X-C motif) ligand 13
ESR1 estrogen receptor 1
FEZ1 fasciculation and elongation protein zeta 1 (zygin I)
FOSL1 FOS-like antigen 1
GAS1 growth arrest-specific 1
GATA6 GATA binding protein 6
HHEX hematopoietically expressed homeobox
HMGCS2 3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)
HMOX1 heme oxygenase 1
HSPA1A heat shock 70kDa protein 1A
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER3 immediate early response 3
LAMA4 laminin, alpha 4
LCN2 lipocalin 2
LEF1 lymphoid enhancer-binding factor 1
MACF1 microtubule-actin crosslinking factor 1
MMP12 matrix metallopeptidase 12
MMP9 matrix metallopeptidase 9
NQO1 NAD(P)H dehydrogenase, quinone 1
OLFM4 olfactomedin 4
PCNA proliferating cell nuclear antigen
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2
QPCT glutaminyl-peptide cyclotransferase
QPRT quinolinate phosphoribosyltransferase
RAI14 retinoic acid induced 14
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
SCG5 secretogranin V
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2
SLC24A3 solute carrier family 24 (sodium/potassium/calcium exchanger), member 3
SMAD3 SMAD family member 3
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
TFF3 trefoil factor 3 (intestinal)
TMEM158 transmembrane protein 158 (gene/pseudogene)
TOX3 TOX high mobility group box family member 3
TRD T cell receptor delta locus