BRD-K00627859_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

213 genes differentially expressed following the BRD-K00627859_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ABHD4 abhydrolase domain containing 4
AKAP12 A kinase (PRKA) anchor protein 12
ALDOC aldolase C, fructose-bisphosphate
ALOX5 arachidonate 5-lipoxygenase
ANXA6 annexin A6
APLP1 amyloid beta (A4) precursor-like protein 1
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATF3 activating transcription factor 3
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide
ATP8A1 ATPase, aminophospholipid transporter (APLT), class I, type 8A, member 1
BAD BCL2-associated agonist of cell death
C14ORF132 chromosome 14 open reading frame 132
CALCOCO2 calcium binding and coiled-coil domain 2
CCL5 chemokine (C-C motif) ligand 5
CD2 CD2 molecule
CD47 CD47 molecule
CD69 CD69 molecule
CD96 CD96 molecule
CDH17 cadherin 17, LI cadherin (liver-intestine)
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CLDND1 claudin domain containing 1
CORO1A coronin, actin binding protein, 1A
COTL1 coactosin-like F-actin binding protein 1
CREM cAMP responsive element modulator
CXCR4 chemokine (C-X-C motif) receptor 4
CYFIP2 cytoplasmic FMR1 interacting protein 2
DDIT4 DNA-damage-inducible transcript 4
DHRS7 dehydrogenase/reductase (SDR family) member 7
EPB41L2 erythrocyte membrane protein band 4.1-like 2
FABP7 fatty acid binding protein 7, brain
FAM171A1 family with sequence similarity 171, member A1
FBLN5 fibulin 5
FCMR Fc fragment of IgM receptor
FOXO4 forkhead box O4
FYB FYN binding protein
GABARAPL1 GABA(A) receptor-associated protein like 1
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GCH1 GTP cyclohydrolase 1
GDF15 growth differentiation factor 15
GEM GTP binding protein overexpressed in skeletal muscle
GLRX glutaredoxin (thioltransferase)
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GSN gelsolin
GSTA4 glutathione S-transferase alpha 4
HMOX1 heme oxygenase 1
HPCAL1 hippocalcin-like 1
HSPA1A heat shock 70kDa protein 1A
IFI27 interferon, alpha-inducible protein 27
IFI6 interferon, alpha-inducible protein 6
IFITM1 interferon induced transmembrane protein 1
IFT57 intraflagellar transport 57
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL2RG interleukin 2 receptor, gamma
IL32 interleukin 32
ITM2A integral membrane protein 2A
ITM2C integral membrane protein 2C
KIF5C kinesin family member 5C
KLRB1 killer cell lectin-like receptor subfamily B, member 1
LCK LCK proto-oncogene, Src family tyrosine kinase
LEF1 lymphoid enhancer-binding factor 1
LPIN1 lipin 1
MAN1A1 mannosidase, alpha, class 1A, member 1
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MID1 midline 1
MLF1 myeloid leukemia factor 1
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MXRA7 matrix-remodelling associated 7
NES nestin
NEU1 sialidase 1 (lysosomal sialidase)
OPN3 opsin 3
PBXIP1 pre-B-cell leukemia homeobox interacting protein 1
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PCSK1 proprotein convertase subtilisin/kexin type 1
PCSK1N proprotein convertase subtilisin/kexin type 1 inhibitor
PEG10 paternally expressed 10
PGF placental growth factor
PLEKHB1 pleckstrin homology domain containing, family B (evectins) member 1
PNMA2 paraneoplastic Ma antigen 2
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
PRKCA protein kinase C, alpha
PROCR protein C receptor, endothelial
RAB29 RAB29, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RBP1 retinol binding protein 1, cellular
RCAN1 regulator of calcineurin 1
REEP1 receptor accessory protein 1
RPS11 ribosomal protein S11
RTN1 reticulon 1
SAT1 spermidine/spermine N1-acetyltransferase 1
SCPEP1 serine carboxypeptidase 1
SEMA4D sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SFTPC surfactant protein C
SGCE sarcoglycan, epsilon
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SOX11 SRY (sex determining region Y)-box 11
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
SRGN serglycin
STAB1 stabilin 1
STK26 serine/threonine protein kinase 26
STOM stomatin
STXBP1 syntaxin binding protein 1
SYNGR3 synaptogyrin 3
SYNM synemin, intermediate filament protein
TMSB15A thymosin beta 15a
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b
TPP1 tripeptidyl peptidase I
TRAC T cell receptor alpha constant
TRBC1 T cell receptor beta constant 1
TRIM2 tripartite motif containing 2
TSPAN7 tetraspanin 7
TUBA1A tubulin, alpha 1a
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
WASF3 WAS protein family, member 3
WFS1 Wolfram syndrome 1 (wolframin)
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADIRF adipogenesis regulatory factor
AKAP8 A kinase (PRKA) anchor protein 8
ANPEP alanyl (membrane) aminopeptidase
ATF1 activating transcription factor 1
ATF5 activating transcription factor 5
AZGP1 alpha-2-glycoprotein 1, zinc-binding
CCND1 cyclin D1
CD24 CD24 molecule
CHERP calcium homeostasis endoplasmic reticulum protein
CKAP4 cytoskeleton-associated protein 4
CRISP3 cysteine-rich secretory protein 3
CSTA cystatin A (stefin A)
DDX21 DEAD (Asp-Glu-Ala-Asp) box helicase 21
DENND2D DENN/MADD domain containing 2D
DSP desmoplakin
DUT deoxyuridine triphosphatase
EPS8L1 EPS8-like 1
EREG epiregulin
ESR1 estrogen receptor 1
FAM20B family with sequence similarity 20, member B
FAP fibroblast activation protein, alpha
FASN fatty acid synthase
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GLUL glutamate-ammonia ligase
GPNMB glycoprotein (transmembrane) nmb
GPRC5A G protein-coupled receptor, class C, group 5, member A
HIST1H2AC histone cluster 1, H2ac
HIST1H2BG histone cluster 1, H2bg
IL1RN interleukin 1 receptor antagonist
ING3 inhibitor of growth family, member 3
IRX5 iroquois homeobox 5
JADE2 jade family PHD finger 2
KAT6B K(lysine) acetyltransferase 6B
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KEAP1 kelch-like ECH-associated protein 1
KLK10 kallikrein-related peptidase 10
KPNB1 karyopherin (importin) beta 1
KRT14 keratin 14, type I
KRT15 keratin 15, type I
KRT19 keratin 19, type I
KRT5 keratin 5, type II
KRT6A keratin 6A, type II
LARP1 La ribonucleoprotein domain family, member 1
LCN2 lipocalin 2
LTF lactotransferrin
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B
MARCKS myristoylated alanine-rich protein kinase C substrate
MEPCE methylphosphate capping enzyme
MFAP5 microfibrillar associated protein 5
MLPH melanophilin
MSMB microseminoprotein, beta-
MT1E metallothionein 1E
MTA1 metastasis associated 1
MYB v-myb avian myeloblastosis viral oncogene homolog
MYC v-myc avian myelocytomatosis viral oncogene homolog
PAF1 Paf1, RNA polymerase II associated factor, homolog (S. cerevisiae)
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PIP prolactin-induced protein
PLK1 polo-like kinase 1
POLR3E polymerase (RNA) III (DNA directed) polypeptide E (80kD)
POSTN periostin, osteoblast specific factor
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1
PSCA prostate stem cell antigen
RBM47 RNA binding motif protein 47
RHOH ras homolog family member H
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
S100A2 S100 calcium binding protein A2
S100A7 S100 calcium binding protein A7
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCNN1A sodium channel, non voltage gated 1 alpha subunit
SLPI secretory leukocyte peptidase inhibitor
SOX4 SRY (sex determining region Y)-box 4
SPDEF SAM pointed domain containing ETS transcription factor
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila)
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein
TACSTD2 tumor-associated calcium signal transducer 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TFAP2A transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
TLR4 toll-like receptor 4
TNS3 tensin 3
VCAN versican
VTCN1 V-set domain containing T cell activation inhibitor 1
XBP1 X-box binding protein 1
ZHX2 zinc fingers and homeoboxes 2