BRD-K00627859_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

111 genes differentially expressed following the BRD-K00627859_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
ALDOC aldolase C, fructose-bisphosphate
ANGPTL4 angiopoietin-like 4
ANXA1 annexin A1
AP3S1 adaptor-related protein complex 3, sigma 1 subunit
ASPH aspartate beta-hydroxylase
C3 complement component 3
CAMK2N1 calcium/calmodulin-dependent protein kinase II inhibitor 1
CAV1 caveolin 1, caveolae protein, 22kDa
CFD complement factor D (adipsin)
COMP cartilage oligomeric matrix protein
CORO1A coronin, actin binding protein, 1A
CRABP1 cellular retinoic acid binding protein 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DUSP1 dual specificity phosphatase 1
ECM1 extracellular matrix protein 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EPAS1 endothelial PAS domain protein 1
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
GALNT6 polypeptide N-acetylgalactosaminyltransferase 6
GLRX glutaredoxin (thioltransferase)
HLA-B major histocompatibility complex, class I, B
IFI16 interferon, gamma-inducible protein 16
IFI27 interferon, alpha-inducible protein 27
IGFBP6 insulin-like growth factor binding protein 6
IL32 interleukin 32
ISG20 interferon stimulated exonuclease gene 20kDa
LGALS1 lectin, galactoside-binding, soluble, 1
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1B microtubule-associated protein 1B
MDK midkine (neurite growth-promoting factor 2)
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11
MME membrane metallo-endopeptidase
MVP major vault protein
NPTX2 neuronal pentraxin II
OLFM4 olfactomedin 4
PDGFD platelet derived growth factor D
PLIN2 perilipin 2
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1)
PTN pleiotrophin
PYGL phosphorylase, glycogen, liver
REEP1 receptor accessory protein 1
SCGB1D2 secretoglobin, family 1D, member 2
SCGB2A1 secretoglobin, family 2A, member 1
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SOX9 SRY (sex determining region Y)-box 9
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1
STC1 stanniocalcin 1
SYNPO synaptopodin
SYT1 synaptotagmin I
TFPI2 tissue factor pathway inhibitor 2
TMSB15A thymosin beta 15a
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TRIM2 tripartite motif containing 2
UBE2L6 ubiquitin-conjugating enzyme E2L 6
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VTCN1 V-set domain containing T cell activation inhibitor 1
WLS wntless Wnt ligand secretion mediator

decreased expression

Symbol Name
ADCK3 aarF domain containing kinase 3
ADI1 acireductone dioxygenase 1
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
AURKA aurora kinase A
BIRC5 baculoviral IAP repeat containing 5
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
CCNA2 cyclin A2
CCNB2 cyclin B2
CDC20 cell division cycle 20
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP55 centrosomal protein 55kDa
CHPT1 choline phosphotransferase 1
DDAH1 dimethylarginine dimethylaminohydrolase 1
DKC1 dyskeratosis congenita 1, dyskerin
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
FOLR1 folate receptor 1 (adult)
FRAT2 frequently rearranged in advanced T-cell lymphomas 2
HMGB2 high mobility group box 2
HMMR hyaluronan-mediated motility receptor (RHAMM)
HSPD1 heat shock 60kDa protein 1 (chaperonin)
KIF14 kinesin family member 14
KIF23 kinesin family member 23
KIF2C kinesin family member 2C
LIG1 ligase I, DNA, ATP-dependent
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
NCAPG non-SMC condensin I complex, subunit G
NDC80 NDC80 kinetochore complex component
NEK2 NIMA-related kinase 2
ODC1 ornithine decarboxylase 1
PBK PDZ binding kinase
PLK1 polo-like kinase 1
PPIG peptidylprolyl isomerase G (cyclophilin G)
PRC1 protein regulator of cytokinesis 1
PTX3 pentraxin 3, long
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B
RFC2 replication factor C (activator 1) 2, 40kDa
SHCBP1 SHC SH2-domain binding protein 1
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2
SPAG5 sperm associated antigen 5
TACC3 transforming, acidic coiled-coil containing protein 3
TOP2A topoisomerase (DNA) II alpha 170kDa
TPX2 TPX2, microtubule-associated
UBE2C ubiquitin-conjugating enzyme E2C