BRD-K00627859_-666_HEPG2_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

111 genes differentially expressed following the BRD-K00627859_-666_HEPG2_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALOX5 arachidonate 5-lipoxygenase
ANXA1 annexin A1
BASP1 brain abundant, membrane attached signal protein 1
CADPS2 Ca++-dependent secretion activator 2
CAV2 caveolin 2
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CEP70 centrosomal protein 70kDa
COL4A5 collagen, type IV, alpha 5
CSTA cystatin A (stefin A)
CYBB cytochrome b-245, beta polypeptide
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCN1 ficolin (collagen/fibrinogen domain containing) 1
FGF13 fibroblast growth factor 13
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
FOXO4 forkhead box O4
FXYD6 FXYD domain containing ion transport regulator 6
GPRASP1 G protein-coupled receptor associated sorting protein 1
GRN granulin
GULP1 GULP, engulfment adaptor PTB domain containing 1
GUSBP11 glucuronidase, beta pseudogene 11
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
IFI44L interferon-induced protein 44-like
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGHM immunoglobulin heavy constant mu
IGKV4-1 immunoglobulin kappa variable 4-1
IGLV2-23 immunoglobulin lambda variable 2-23
IKZF1 IKAROS family zinc finger 1 (Ikaros)
ISG15 ISG15 ubiquitin-like modifier
ITM2A integral membrane protein 2A
JCHAIN joining chain of multimeric IgA and IgM
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KRT7 keratin 7, type II
LDHB lactate dehydrogenase B
LTF lactotransferrin
LYN LYN proto-oncogene, Src family tyrosine kinase
MEF2C myocyte enhancer factor 2C
MNDA myeloid cell nuclear differentiation antigen
MX1 MX dynamin-like GTPase 1
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
NR1H2 nuclear receptor subfamily 1, group H, member 2
NR2F2 nuclear receptor subfamily 2, group F, member 2
NTS neurotensin
OLFM1 olfactomedin 1
OLFM4 olfactomedin 4
OPN3 opsin 3
PDGFA platelet-derived growth factor alpha polypeptide
PNMAL1 paraneoplastic Ma antigen family-like 1
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta
PTN pleiotrophin
RTN1 reticulon 1
S100A6 S100 calcium binding protein A6
S100A8 S100 calcium binding protein A8
S100A9 S100 calcium binding protein A9
SCGB2A2 secretoglobin, family 2A, member 2
SCPEP1 serine carboxypeptidase 1
SEPT6 septin 6
SH2B3 SH2B adaptor protein 3
SLC1A1 solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14
SNAP25 synaptosomal-associated protein, 25kDa
SYT1 synaptotagmin I
TCFL5 transcription factor-like 5 (basic helix-loop-helix)
THEMIS2 thymocyte selection associated family member 2
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TPM2 tropomyosin 2 (beta)
TRIB2 tribbles pseudokinase 2
TRIM2 tripartite motif containing 2
UCHL1 ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VLDLR very low density lipoprotein receptor
WASF1 WAS protein family, member 1

decreased expression

Symbol Name
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase
ABLIM1 actin binding LIM protein 1
ADGRG6 adhesion G protein-coupled receptor G6
AHNAK2 AHNAK nucleoprotein 2
APOH apolipoprotein H (beta-2-glycoprotein I)
CA12 carbonic anhydrase XII
CRIP1 cysteine-rich protein 1 (intestinal)
CTGF connective tissue growth factor
CYR61 cysteine-rich, angiogenic inducer, 61
DARS aspartyl-tRNA synthetase
DICER1 dicer 1, ribonuclease type III
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLC1 DLC1 Rho GTPase activating protein
ECM1 extracellular matrix protein 1
EPHA2 EPH receptor A2
FAM57A family with sequence similarity 57, member A
FERMT1 fermitin family member 1
FGFR3 fibroblast growth factor receptor 3
FLG filaggrin
IL1R2 interleukin 1 receptor, type II
KPNB1 karyopherin (importin) beta 1
KRT1 keratin 1, type II
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4
POSTN periostin, osteoblast specific factor
PPP1R3C protein phosphatase 1, regulatory subunit 3C
PRR7 proline rich 7 (synaptic)
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1
SLC38A1 solute carrier family 38, member 1
SRSF1 serine/arginine-rich splicing factor 1
TF transferrin
THBS1 thrombospondin 1
TM4SF1 transmembrane 4 L six family member 1