BRD-K00615600_Unable to generate chemical name O-4537-1_A375_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

81 genes differentially expressed following the BRD-K00615600_Unable to generate chemical name O-4537-1_A375_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ACKR3 atypical chemokine receptor 3
ACP6 acid phosphatase 6, lysophosphatidic
ADAM12 ADAM metallopeptidase domain 12
ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif, 5
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
AREG amphiregulin
ATF3 activating transcription factor 3
BAX BCL2-associated X protein
BCL2A1 BCL2-related protein A1
BEX4 brain expressed, X-linked 4
CBLB Cbl proto-oncogene B, E3 ubiquitin protein ligase
CCL22 chemokine (C-C motif) ligand 22
CCNG1 cyclin G1
CD40 CD40 molecule, TNF receptor superfamily member 5
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CXCL8 chemokine (C-X-C motif) ligand 8
DDB2 damage-specific DNA binding protein 2, 48kDa
DUSP2 dual specificity phosphatase 2
DUSP4 dual specificity phosphatase 4
FADS1 fatty acid desaturase 1
FGL1 fibrinogen-like 1
FST follistatin
G0S2 G0/G1 switch 2
GATA3 GATA binding protein 3
IFI27 interferon, alpha-inducible protein 27
ISG15 ISG15 ubiquitin-like modifier
LIMA1 LIM domain and actin binding 1
LY75 lymphocyte antigen 75
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
PDLIM4 PDZ and LIM domain 4
PSD3 pleckstrin and Sec7 domain containing 3
SCG5 secretogranin V
SCYL3 SCY1-like 3 (S. cerevisiae)
SESN1 sestrin 1
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3
SMAD1 SMAD family member 1
SULF1 sulfatase 1
TFAP2B transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
THBS1 thrombospondin 1
THBS2 thrombospondin 2
TIMP3 TIMP metallopeptidase inhibitor 3
TNC tenascin C
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TOX3 TOX high mobility group box family member 3
WBP5 WW domain binding protein 5
ZFP36L2 ZFP36 ring finger protein-like 2
ZMAT3 zinc finger, matrin-type 3

decreased expression

Symbol Name
ALDH5A1 aldehyde dehydrogenase 5 family, member A1
AUTS2 autism susceptibility candidate 2
C1QA complement component 1, q subcomponent, A chain
C1QB complement component 1, q subcomponent, B chain
CD24 CD24 molecule
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL4A2 collagen, type IV, alpha 2
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
E2F2 E2F transcription factor 2
EZR ezrin
GPM6A glycoprotein M6A
HBB hemoglobin, beta
IGFBP7 insulin-like growth factor binding protein 7
IGHM immunoglobulin heavy constant mu
LEF1 lymphoid enhancer-binding factor 1
LOC100505650 uncharacterized LOC100505650
MAN1C1 mannosidase, alpha, class 1C, member 1
MYH11 myosin, heavy chain 11, smooth muscle
PODXL podocalyxin-like
PUF60 poly-U binding splicing factor 60KDa
RAD21 RAD21 homolog (S. pombe)
RASSF2 Ras association (RalGDS/AF-6) domain family member 2
RUNX3 runt-related transcription factor 3
SFTPC surfactant protein C
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SPTBN1 spectrin, beta, non-erythrocytic 1
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
TGFBR3 transforming growth factor, beta receptor III
WT1 Wilms tumor 1