BRD-K00603606_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

80 genes differentially expressed following the BRD-K00603606_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ARG2 arginase 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CFB complement factor B
CPB1 carboxypeptidase B1 (tissue)
CPE carboxypeptidase E
CTSH cathepsin H
CX3CL1 chemokine (C-X3-C motif) ligand 1
DLK1 delta-like 1 homolog (Drosophila)
FAM69A family with sequence similarity 69, member A
FBXL7 F-box and leucine-rich repeat protein 7
FILIP1L filamin A interacting protein 1-like
GALNT3 polypeptide N-acetylgalactosaminyltransferase 3
GJA1 gap junction protein, alpha 1, 43kDa
GNLY granulysin
GP2 glycoprotein 2 (zymogen granule membrane)
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HS2ST1 heparan sulfate 2-O-sulfotransferase 1
IRF9 interferon regulatory factor 9
KLK5 kallikrein-related peptidase 5
KRT23 keratin 23, type I
LCN2 lipocalin 2
MAN2A1 mannosidase, alpha, class 2A, member 1
MMP7 matrix metallopeptidase 7
MMP9 matrix metallopeptidase 9
MT1F metallothionein 1F
OSBPL10 oxysterol binding protein-like 10
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCP4 Purkinje cell protein 4
PEG3 paternally expressed 3
PPP1R3C protein phosphatase 1, regulatory subunit 3C
QPCT glutaminyl-peptide cyclotransferase
RGCC regulator of cell cycle
RNASE1 ribonuclease, RNase A family, 1 (pancreatic)
S100P S100 calcium binding protein P
SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
SUCO SUN domain containing ossification factor
WT1 Wilms tumor 1
ZFPM2 zinc finger protein, FOG family member 2

decreased expression

Symbol Name
ADD3 adducin 3 (gamma)
BDH2 3-hydroxybutyrate dehydrogenase, type 2
CCND1 cyclin D1
FABP7 fatty acid binding protein 7, brain
FAR2 fatty acyl CoA reductase 2
FOLR1 folate receptor 1 (adult)
FSCN1 fascin actin-bundling protein 1
GADD45B growth arrest and DNA-damage-inducible, beta
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2
GAS1 growth arrest-specific 1
GPM6B glycoprotein M6B
GPX4 glutathione peroxidase 4
HNRNPL heterogeneous nuclear ribonucleoprotein L
HOXB7 homeobox B7
IQGAP1 IQ motif containing GTPase activating protein 1
LPL lipoprotein lipase
MAGEA12 melanoma antigen family A12
MAGEA3 melanoma antigen family A3
MAGEA6 melanoma antigen family A6
METRN meteorin, glial cell differentiation regulator
MXI1 MAX interactor 1, dimerization protein
NRN1 neuritin 1
PLAC8 placenta-specific 8
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLIN3 perilipin 3
PPDPF pancreatic progenitor cell differentiation and proliferation factor
PROSC proline synthetase co-transcribed homolog (bacterial)
RPL38 ribosomal protein L38
RRAGD Ras-related GTP binding D
S100A7 S100 calcium binding protein A7
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SET SET nuclear proto-oncogene
SRSF6 serine/arginine-rich splicing factor 6
TKT transketolase
TTC3 tetratricopeptide repeat domain 3
TUBB2A tubulin, beta 2A class IIa
TUBB2B tubulin, beta 2B class IIb
UBE2S ubiquitin-conjugating enzyme E2S