BRD-K00317371_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
Similar Terms
Downloads & Tools

Genes

427 genes differentially expressed following the BRD-K00317371_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABHD4 abhydrolase domain containing 4
ADO 2-aminoethanethiol (cysteamine) dioxygenase
AIF1 allograft inflammatory factor 1
AK2 adenylate kinase 2
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
ANGPTL2 angiopoietin-like 2
ANOS1 anosmin 1
ANXA4 annexin A4
AP3D1 adaptor-related protein complex 3, delta 1 subunit
AQP3 aquaporin 3 (Gill blood group)
ARG2 arginase 2
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
BCAM basal cell adhesion molecule (Lutheran blood group)
CALD1 caldesmon 1
CASP10 caspase 10, apoptosis-related cysteine peptidase
CAV1 caveolin 1, caveolae protein, 22kDa
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL5 chemokine (C-C motif) ligand 5
CCND2 cyclin D2
CCND3 cyclin D3
CD163 CD163 molecule
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHMP4A charged multivesicular body protein 4A
CKB creatine kinase, brain
CLC Charcot-Leyden crystal galectin
CLEC2B C-type lectin domain family 2, member B
CLGN calmegin
CLTB clathrin, light chain B
COL10A1 collagen, type X, alpha 1
COL11A1 collagen, type XI, alpha 1
COL5A2 collagen, type V, alpha 2
COL6A1 collagen, type VI, alpha 1
COL6A2 collagen, type VI, alpha 2
COL9A2 collagen, type IX, alpha 2
COTL1 coactosin-like F-actin binding protein 1
CPE carboxypeptidase E
CTSK cathepsin K
CTSL cathepsin L
CXADR coxsackie virus and adenovirus receptor
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCL9 chemokine (C-X-C motif) ligand 9
CYBRD1 cytochrome b reductase 1
DEGS1 delta(4)-desaturase, sphingolipid 1
DKK3 dickkopf WNT signaling pathway inhibitor 3
DPYSL3 dihydropyrimidinase-like 3
DRAP1 DR1-associated protein 1 (negative cofactor 2 alpha)
EIF1AY eukaryotic translation initiation factor 1A, Y-linked
EIF3I eukaryotic translation initiation factor 3, subunit I
EMP3 epithelial membrane protein 3
EPAS1 endothelial PAS domain protein 1
EPHX1 epoxide hydrolase 1, microsomal (xenobiotic)
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2
FABP4 fatty acid binding protein 4, adipocyte
FAM129A family with sequence similarity 129, member A
FAM46A family with sequence similarity 46, member A
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FCGR2C Fc fragment of IgG, low affinity IIc, receptor for (CD32) (gene/pseudogene)
FGFR3 fibroblast growth factor receptor 3
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
FSTL1 follistatin-like 1
FTH1 ferritin, heavy polypeptide 1
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GBP1 guanylate binding protein 1, interferon-inducible
GDI1 GDP dissociation inhibitor 1
GJA1 gap junction protein, alpha 1, 43kDa
GNG11 guanine nucleotide binding protein (G protein), gamma 11
GPC4 glypican 4
GPX1 glutathione peroxidase 1
GPX3 glutathione peroxidase 3
GUK1 guanylate kinase 1
HBEGF heparin-binding EGF-like growth factor
HIST2H2BE histone cluster 2, H2be
HLA-A major histocompatibility complex, class I, A
HLA-B major histocompatibility complex, class I, B
HLA-C major histocompatibility complex, class I, C
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1
HLA-F major histocompatibility complex, class I, F
HLA-G major histocompatibility complex, class I, G
HSPB11 heat shock protein family B (small), member 11
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein
ID2 inhibitor of DNA binding 2, dominant negative helix-loop-helix protein
IDO1 indoleamine 2,3-dioxygenase 1
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IGFBP3 insulin-like growth factor binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
INSM1 insulinoma-associated 1
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor)
ITGB5 integrin, beta 5
JAG1 jagged 1
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3
KCTD5 potassium channel tetramerization domain containing 5
KDR kinase insert domain receptor
KRT17 keratin 17, type I
LAMP3 lysosomal-associated membrane protein 3
LIMCH1 LIM and calponin homology domains 1
LRRC15 leucine rich repeat containing 15
LUM lumican
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
MAGEA3 melanoma antigen family A3
MAP1B microtubule-associated protein 1B
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2
MIR22HG MIR22 host gene
MMP12 matrix metallopeptidase 12
MMP24 matrix metallopeptidase 24 (membrane-inserted)
MSN moesin
MT1F metallothionein 1F
MXRA5 matrix-remodelling associated 5
NBL1 neuroblastoma 1, DAN family BMP antagonist
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NMU neuromedin U
NT5E 5'-nucleotidase, ecto (CD73)
OLFM4 olfactomedin 4
OLFML2A olfactomedin-like 2A
P4HTM prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PDLIM1 PDZ and LIM domain 1
PDLIM2 PDZ and LIM domain 2 (mystique)
PDLIM7 PDZ and LIM domain 7 (enigma)
PDZK1IP1 PDZK1 interacting protein 1
PEA15 phosphoprotein enriched in astrocytes 15
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PLS3 plastin 3
PLVAP plasmalemma vesicle associated protein
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
POMGNT1 protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-)
PRUNE2 prune homolog 2 (Drosophila)
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9
PTGER4 prostaglandin E receptor 4 (subtype EP4)
PTP4A3 protein tyrosine phosphatase type IVA, member 3
PTRF polymerase I and transcript release factor
PYCARD PYD and CARD domain containing
RGCC regulator of cell cycle
SAT1 spermidine/spermine N1-acetyltransferase 1
SCG2 secretogranin II
SCPEP1 serine carboxypeptidase 1
SDC3 syndecan 3
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2
SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1
SESN1 sestrin 1
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5
SNAI2 snail family zinc finger 2
STXBP2 syntaxin binding protein 2
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3
TFPI2 tissue factor pathway inhibitor 2
TGFA transforming growth factor, alpha
TGFB1I1 transforming growth factor beta 1 induced transcript 1
TGFBI transforming growth factor, beta-induced, 68kDa
THBS2 thrombospondin 2
THY1 Thy-1 cell surface antigen
TIMP3 TIMP metallopeptidase inhibitor 3
TMEM158 transmembrane protein 158 (gene/pseudogene)
TMEM45A transmembrane protein 45A
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TPSAB1 tryptase alpha/beta 1
TPSB2 tryptase beta 2 (gene/pseudogene)
TUBA4A tubulin, alpha 4a
VAMP1 vesicle-associated membrane protein 1 (synaptobrevin 1)
VEGFA vascular endothelial growth factor A
VIM vimentin
XCL1 chemokine (C motif) ligand 1
ZDHHC11 zinc finger, DHHC-type containing 11

decreased expression

Symbol Name
ADNP activity-dependent neuroprotector homeobox
AKR1C1 aldo-keto reductase family 1, member C1
AKR1C2 aldo-keto reductase family 1, member C2
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3B2 aldehyde dehydrogenase 3 family, member B2
ANKRD17 ankyrin repeat domain 17
ARFGEF1 ADP-ribosylation factor guanine nucleotide-exchange factor 1 (brefeldin A-inhibited)
ARHGAP12 Rho GTPase activating protein 12
ARID1A AT rich interactive domain 1A (SWI-like)
ARID4B AT rich interactive domain 4B (RBP1-like)
ARMT1 acidic residue methyltransferase 1
ASF1A anti-silencing function 1A histone chaperone
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
ASXL2 additional sex combs like transcriptional regulator 2
ATAD2 ATPase family, AAA domain containing 2
ATP13A3 ATPase type 13A3
ATP5C1 ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
AURKA aurora kinase A
B3GNT1
BAMBI BMP and activin membrane-bound inhibitor
BARD1 BRCA1 associated RING domain 1
BAZ1A bromodomain adjacent to zinc finger domain, 1A
BCL2 B-cell CLL/lymphoma 2
BCL6 B-cell CLL/lymphoma 6
BLM Bloom syndrome, RecQ helicase-like
BMPR1A bone morphogenetic protein receptor, type IA
BUB1 BUB1 mitotic checkpoint serine/threonine kinase
C1ORF112 chromosome 1 open reading frame 112
C6ORF62 chromosome 6 open reading frame 62
CA12 carbonic anhydrase XII
CAPN6 calpain 6
CAPN7 calpain 7
CASP8AP2 caspase 8 associated protein 2
CCNA2 cyclin A2
CCNG2 cyclin G2
CD58 CD58 molecule
CDC123 cell division cycle 123
CDK1 cyclin-dependent kinase 1
CDK7 cyclin-dependent kinase 7
CDKN3 cyclin-dependent kinase inhibitor 3
CDYL chromodomain protein, Y-like
CENPA centromere protein A
CENPF centromere protein F, 350/400kDa
CEP350 centrosomal protein 350kDa
CGRRF1 cell growth regulator with ring finger domain 1
CHD1 chromodomain helicase DNA binding protein 1
CKS2 CDC28 protein kinase regulatory subunit 2
CNOT4 CCR4-NOT transcription complex, subunit 4
COIL coilin
DAAM1 dishevelled associated activator of morphogenesis 1
DAPK1 death-associated protein kinase 1
DBF4 DBF4 zinc finger
DCK deoxycytidine kinase
DCLRE1C DNA cross-link repair 1C
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10
DENND2D DENN/MADD domain containing 2D
DHRS2 dehydrogenase/reductase (SDR family) member 2
DKFZP586I1420 uncharacterized protein DKFZp586I1420
DKK1 dickkopf WNT signaling pathway inhibitor 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DNAAF2 dynein, axonemal, assembly factor 2
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A
ECT2 epithelial cell transforming 2
EIF4B eukaryotic translation initiation factor 4B
EIF4E eukaryotic translation initiation factor 4E
ELOVL2 ELOVL fatty acid elongase 2
ELOVL6 ELOVL fatty acid elongase 6
ENC1 ectodermal-neural cortex 1 (with BTB domain)
ENSA endosulfine alpha
ESR1 estrogen receptor 1
FA2H fatty acid 2-hydroxylase
FABP7 fatty acid binding protein 7, brain
FAM208A family with sequence similarity 208, member A
FAM208B family with sequence similarity 208, member B
FOXJ3 forkhead box J3
FOXO3 forkhead box O3
FRYL FRY-like
GABPB1 GA binding protein transcription factor, beta subunit 1
GATA3 GATA binding protein 3
GDI2 GDP dissociation inhibitor 2
GPATCH8 G patch domain containing 8
GREB1 growth regulation by estrogen in breast cancer 1
HELLS helicase, lymphoid-specific
HILPDA hypoxia inducible lipid droplet-associated
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
HOXC10 homeobox C10
HOXC6 homeobox C6
HSPA8 heat shock 70kDa protein 8
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
IDI1 isopentenyl-diphosphate delta isomerase 1
IFI44L interferon-induced protein 44-like
IGF1R insulin-like growth factor 1 receptor
INSIG1 insulin induced gene 1
IPO7 importin 7
IRX5 iroquois homeobox 5
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1
JARID2 jumonji, AT rich interactive domain 2
KANK1 KN motif and ankyrin repeat domains 1
KCNK1 potassium channel, two pore domain subfamily K, member 1
KDM5B lysine (K)-specific demethylase 5B
KIAA0101 KIAA0101
KIAA0232 KIAA0232
KIAA0485 uncharacterized LOC57235
KIF11 kinesin family member 11
KIF18A kinesin family member 18A
KIN Kin17 DNA and RNA binding protein
KLF6 Kruppel-like factor 6
KLHL9 kelch-like family member 9
KMT2A lysine (K)-specific methyltransferase 2A
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1)
KYNU kynureninase
LARP4B La ribonucleoprotein domain family, member 4B
LMO2 LIM domain only 2 (rhombotin-like 1)
MAP3K4 mitogen-activated protein kinase kinase kinase 4
MAPK6 mitogen-activated protein kinase 6
MARCH7 membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
MCM10 minichromosome maintenance complex component 10
MED13 mediator complex subunit 13
MEGF9 multiple EGF-like-domains 9
MELK maternal embryonic leucine zipper kinase
METTL18 methyltransferase like 18
MGP matrix Gla protein
MIOS missing oocyte, meiosis regulator, homolog (Drosophila)
MKI67 marker of proliferation Ki-67
MKL2 MKL/myocardin-like 2
MNAT1 MNAT CDK-activating kinase assembly factor 1
MPZL1 myelin protein zero-like 1
MREG melanoregulin
MRPL15 mitochondrial ribosomal protein L15
MSH6 mutS homolog 6
MTF2 metal response element binding transcription factor 2
MYC v-myc avian myelocytomatosis viral oncogene homolog
NCALD neurocalcin delta
NCK1 NCK adaptor protein 1
NCOA3 nuclear receptor coactivator 3
NEK7 NIMA-related kinase 7
NET1 neuroepithelial cell transforming 1
NFIB nuclear factor I/B
NMD3 NMD3 ribosome export adaptor
NOTCH2 notch 2
NOTCH2NL notch 2 N-terminal like
NPAT nuclear protein, ataxia-telangiectasia locus
NPEPPS aminopeptidase puromycin sensitive
NRIP1 nuclear receptor interacting protein 1
ODAM odontogenic, ameloblast asssociated
OPN3 opsin 3
PANK3 pantothenate kinase 3
PARP2 poly (ADP-ribose) polymerase 2
PATZ1 POZ (BTB) and AT hook containing zinc finger 1
PBK PDZ binding kinase
PDS5A PDS5 cohesin associated factor A
PDS5B PDS5 cohesin associated factor B
PEX11A peroxisomal biogenesis factor 11 alpha
PIAS1 protein inhibitor of activated STAT, 1
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R4 phosphoinositide-3-kinase, regulatory subunit 4
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLK4 polo-like kinase 4
POGZ pogo transposable element with ZNF domain
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
PPFIBP2 PTPRF interacting protein, binding protein 2 (liprin beta 2)
PROM1 prominin 1
PRPF4B pre-mRNA processing factor 4B
PSCA prostate stem cell antigen
PSRC1 proline/serine-rich coiled-coil 1
PTK2 protein tyrosine kinase 2
PUM2 pumilio RNA-binding family member 2
RAB14 RAB14, member RAS oncogene family
RABGAP1 RAB GTPase activating protein 1
RAD54B RAD54 homolog B (S. cerevisiae)
RBM7 RNA binding motif protein 7
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit
RFC3 replication factor C (activator 1) 3, 38kDa
RMND1 required for meiotic nuclear division 1 homolog (S. cerevisiae)
RNF111 ring finger protein 111
RPP38 ribonuclease P/MRP 38kDa subunit
SCAF8 SR-related CTD-associated factor 8
SCAMP1 secretory carrier membrane protein 1
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SCYL3 SCY1-like 3 (S. cerevisiae)
SECISBP2L SECIS binding protein 2-like
SELT selenoprotein T
SEPHS1 selenophosphate synthetase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SETD5 SET domain containing 5
SETX senataxin
SIAH2 siah E3 ubiquitin protein ligase 2
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13
SLC26A2 solute carrier family 26 (anion exchanger), member 2
SLC2A10 solute carrier family 2 (facilitated glucose transporter), member 10
SLC38A1 solute carrier family 38, member 1
SLC38A2 solute carrier family 38, member 2
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3
SLC9A3R1 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 1
SMC4 structural maintenance of chromosomes 4
SORL1 sortilin-related receptor, L(DLR class) A repeats containing
SPDEF SAM pointed domain containing ETS transcription factor
SPTLC2 serine palmitoyltransferase, long chain base subunit 2
SSBP2 single-stranded DNA binding protein 2
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6
SYPL1 synaptophysin-like 1
TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TEX10 testis expressed 10
TGFBR3 transforming growth factor, beta receptor III
TGIF1 TGFB-induced factor homeobox 1
TIAM1 T-cell lymphoma invasion and metastasis 1
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TLK1 tousled-like kinase 1
TLK2 tousled-like kinase 2
TMEM100 transmembrane protein 100
TMEM135 transmembrane protein 135
TMPO thymopoietin
TOP2A topoisomerase (DNA) II alpha 170kDa
TRIM33 tripartite motif containing 33
TRPS1 trichorhinophalangeal syndrome I
TSC22D2 TSC22 domain family, member 2
TSPYL5 TSPY-like 5
TTK TTK protein kinase
UBR5 ubiquitin protein ligase E3 component n-recognin 5
UCK2 uridine-cytidine kinase 2
UGCG UDP-glucose ceramide glucosyltransferase
UPF2 UPF2 regulator of nonsense transcripts homolog (yeast)
USP6NL USP6 N-terminal like
UTP14C UTP14, U3 small nucleolar ribonucleoprotein, homolog C (yeast)
VEZF1 vascular endothelial zinc finger 1
VGLL4 vestigial-like family member 4
WAC WW domain containing adaptor with coiled-coil
WAPAL wings apart-like homolog (Drosophila)
WEE1 WEE1 G2 checkpoint kinase
XBP1 X-box binding protein 1
YAF2 YY1 associated factor 2
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
ZBTB1 zinc finger and BTB domain containing 1
ZBTB38 zinc finger and BTB domain containing 38
ZC3H13 zinc finger CCCH-type containing 13
ZC3H4 zinc finger CCCH-type containing 4
ZHX2 zinc fingers and homeoboxes 2
ZMIZ1 zinc finger, MIZ-type containing 1
ZMYND8 zinc finger, MYND-type containing 8
ZNF148 zinc finger protein 148
ZNF217 zinc finger protein 217
ZNF292 zinc finger protein 292
ZWILCH zwilch kinetochore protein