BRD-K00028814_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

121 genes differentially expressed following the BRD-K00028814_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3
APOLD1 apolipoprotein L domain containing 1
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2
ASNS asparagine synthetase (glutamine-hydrolyzing)
ASS1 argininosuccinate synthase 1
ATF3 activating transcription factor 3
BTG1 B-cell translocation gene 1, anti-proliferative
CBS cystathionine-beta-synthase
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1
CPD carboxypeptidase D
CPNE1 copine I
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EDNRA endothelin receptor type A
EIF4B eukaryotic translation initiation factor 4B
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FXYD5 FXYD domain containing ion transport regulator 5
GBP2 guanylate binding protein 2, interferon-inducible
GLUL glutamate-ammonia ligase
HMGA1 high mobility group AT-hook 1
HMOX1 heme oxygenase 1
ISLR immunoglobulin superfamily containing leucine-rich repeat
LAMB3 laminin, beta 3
MAGEA3 melanoma antigen family A3
MMP9 matrix metallopeptidase 9
MXRA5 matrix-remodelling associated 5
NBPF10 neuroblastoma breakpoint family, member 10
NFIL3 nuclear factor, interleukin 3 regulated
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha
P2RX5 purinergic receptor P2X, ligand gated ion channel, 5
PHGDH phosphoglycerate dehydrogenase
PLAU plasminogen activator, urokinase
PSAT1 phosphoserine aminotransferase 1
RAP1GAP RAP1 GTPase activating protein
S100A2 S100 calcium binding protein A2
S100P S100 calcium binding protein P
SARS seryl-tRNA synthetase
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial)
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
SOX4 SRY (sex determining region Y)-box 4
SPATS2L spermatogenesis associated, serine-rich 2-like
SQSTM1 sequestosome 1
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TSC22D3 TSC22 domain family, member 3
TSKU tsukushi, small leucine rich proteoglycan
VAT1 vesicle amine transport 1
WDR45 WD repeat domain 45

decreased expression

Symbol Name
ADI1 acireductone dioxygenase 1
ASF1B anti-silencing function 1B histone chaperone
ATAD2 ATPase family, AAA domain containing 2
BIRC5 baculoviral IAP repeat containing 5
CA2 carbonic anhydrase II
CCNA2 cyclin A2
CCNE2 cyclin E2
CDC6 cell division cycle 6
CDK1 cyclin-dependent kinase 1
CENPA centromere protein A
CENPU centromere protein U
CEP55 centrosomal protein 55kDa
CLPTM1 cleft lip and palate associated transmembrane protein 1
DHCR24 24-dehydrocholesterol reductase
DHCR7 7-dehydrocholesterol reductase
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DUT deoxyuridine triphosphatase
FANCI Fanconi anemia, complementation group I
FASTKD5 FAST kinase domains 5
FEN1 flap structure-specific endonuclease 1
FOXM1 forkhead box M1
GINS2 GINS complex subunit 2 (Psf2 homolog)
GTPBP8 GTP-binding protein 8 (putative)
HACD3 3-hydroxyacyl-CoA dehydratase 3
HELLS helicase, lymphoid-specific
HIST1H4C histone cluster 1, H4c
IGHM immunoglobulin heavy constant mu
KIF20A kinesin family member 20A
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MCM10 minichromosome maintenance complex component 10
MCM3 minichromosome maintenance complex component 3
MCM5 minichromosome maintenance complex component 5
MCM6 minichromosome maintenance complex component 6
ME1 malic enzyme 1, NADP(+)-dependent, cytosolic
MELK maternal embryonic leucine zipper kinase
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
NCAPG2 non-SMC condensin II complex, subunit G2
PBK PDZ binding kinase
PCNA proliferating cell nuclear antigen
PHACTR2 phosphatase and actin regulator 2
PIN1 peptidylprolyl cis/trans isomerase, NIMA-interacting 1
PLK1 polo-like kinase 1
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit
RAD51AP1 RAD51 associated protein 1
RFC2 replication factor C (activator 1) 2, 40kDa
RFC3 replication factor C (activator 1) 3, 38kDa
RFC5 replication factor C (activator 1) 5, 36.5kDa
RRM1 ribonucleotide reductase M1
RRM2 ribonucleotide reductase M2
SAR1B secretion associated, Ras related GTPase 1B
SC5D sterol-C5-desaturase
SDC2 syndecan 2
SHCBP1 SHC SH2-domain binding protein 1
SMAD1 SMAD family member 1
SMC2 structural maintenance of chromosomes 2
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12)
SPC25 SPC25, NDC80 kinetochore complex component
STMN1 stathmin 1
TK1 thymidine kinase 1, soluble
TMEM14A transmembrane protein 14A
TMPO thymopoietin
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10
TTK TTK protein kinase
TUBB2A tubulin, beta 2A class IIa
VBP1 von Hippel-Lindau binding protein 1
ZWINT ZW10 interacting kinetochore protein