BRD-K00007652_-666_MCF7_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

88 genes differentially expressed following the BRD-K00007652_-666_MCF7_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
APOBEC3B apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B
C3AR1 complement component 3a receptor 1
CBR3 carbonyl reductase 3
CCL20 chemokine (C-C motif) ligand 20
CFB complement factor B
CLDN10 claudin 10
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL11 chemokine (C-X-C motif) ligand 11
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DACH1 dachshund family transcription factor 1
DDIT3 DNA-damage-inducible transcript 3
DDIT4 DNA-damage-inducible transcript 4
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1
DNAJC12 DnaJ (Hsp40) homolog, subfamily C, member 12
EAF2 ELL associated factor 2
EPB41L3 erythrocyte membrane protein band 4.1-like 3
FGF13 fibroblast growth factor 13
FMO1 flavin containing monooxygenase 1
GDF15 growth differentiation factor 15
GLRX glutaredoxin (thioltransferase)
GRIA2 glutamate receptor, ionotropic, AMPA 2
HMOX1 heme oxygenase 1
HSPA6 heat shock 70kDa protein 6 (HSP70B')
HSPB8 heat shock 22kDa protein 8
IDO1 indoleamine 2,3-dioxygenase 1
IER3 immediate early response 3
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
KRT23 keratin 23, type I
KRT81 keratin 81, type II
LXN latexin
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP7 microtubule-associated protein 7
MNDA myeloid cell nuclear differentiation antigen
NEFH neurofilament, heavy polypeptide
NEFL neurofilament, light polypeptide
OSBPL10 oxysterol binding protein-like 10
PDE4B phosphodiesterase 4B, cAMP-specific
PDZK1IP1 PDZK1 interacting protein 1
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLIN2 perilipin 2
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H
PRAME preferentially expressed antigen in melanoma
PRKACB protein kinase, cAMP-dependent, catalytic, beta
QPCT glutaminyl-peptide cyclotransferase
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RFX5 regulatory factor X, 5 (influences HLA class II expression)
RNASE6 ribonuclease, RNase A family, k6
SAT1 spermidine/spermine N1-acetyltransferase 1
SCGB1D2 secretoglobin, family 1D, member 2
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2
SOD2 superoxide dismutase 2, mitochondrial
SOX9 SRY (sex determining region Y)-box 9
STMN2 stathmin 2
STS steroid sulfatase (microsomal), isozyme S
SYT1 synaptotagmin I
TGFA transforming growth factor, alpha
TLR4 toll-like receptor 4
TM4SF1 transmembrane 4 L six family member 1
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFAIP3 tumor necrosis factor, alpha-induced protein 3
TSPAN8 tetraspanin 8
VNN1 vanin 1
WFDC1 WAP four-disulfide core domain 1
ZMYND8 zinc finger, MYND-type containing 8

decreased expression

Symbol Name
CA12 carbonic anhydrase XII
COL5A1 collagen, type V, alpha 1
COL6A1 collagen, type VI, alpha 1
CPNE3 copine III
EFEMP1 EGF containing fibulin-like extracellular matrix protein 1
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H)
IFI6 interferon, alpha-inducible protein 6
ISG15 ISG15 ubiquitin-like modifier
KRT17 keratin 17, type I
MX2 MX dynamin-like GTPase 2
N4BP2L2 NEDD4 binding protein 2-like 2
NAT1 N-acetyltransferase 1 (arylamine N-acetyltransferase)
PLEKHM1 pleckstrin homology domain containing, family M (with RUN domain) member 1
PRKCD protein kinase C, delta
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae)
SFTPC surfactant protein C
SLC26A3 solute carrier family 26 (anion exchanger), member 3
SNX7 sorting nexin 7
TIMP3 TIMP metallopeptidase inhibitor 3