BRD-K00007652_-666_MCF7_24.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

155 genes differentially expressed following the BRD-K00007652_-666_MCF7_24.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
ALB albumin
ANXA1 annexin A1
ARL4C ADP-ribosylation factor-like 4C
ATF3 activating transcription factor 3
ATP11B ATPase, class VI, type 11B
CAPN2 calpain 2, (m/II) large subunit
CD9 CD9 molecule
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)
CLC Charcot-Leyden crystal galectin
COL6A2 collagen, type VI, alpha 2
COLEC12 collectin sub-family member 12
CPA3 carboxypeptidase A3 (mast cell)
CXCL8 chemokine (C-X-C motif) ligand 8
DDIT4 DNA-damage-inducible transcript 4
DUSP4 dual specificity phosphatase 4
EDN1 endothelin 1
EGLN3 egl-9 family hypoxia-inducible factor 3
EMP3 epithelial membrane protein 3
EPAS1 endothelial PAS domain protein 1
F13A1 coagulation factor XIII, A1 polypeptide
FN1 fibronectin 1
FOSL1 FOS-like antigen 1
FSTL1 follistatin-like 1
FTH1 ferritin, heavy polypeptide 1
FXYD5 FXYD domain containing ion transport regulator 5
GABRE gamma-aminobutyric acid (GABA) A receptor, epsilon
GAGE3 G antigen 3
GBP1 guanylate binding protein 1, interferon-inducible
GDPD5 glycerophosphodiester phosphodiesterase domain containing 5
GLRX glutaredoxin (thioltransferase)
GPR161 G protein-coupled receptor 161
HIST1H1C histone cluster 1, H1c
HIST2H2BE histone cluster 2, H2be
HMOX1 heme oxygenase 1
HOMER3 homer scaffolding protein 3
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11
ID4 inhibitor of DNA binding 4, dominant negative helix-loop-helix protein
IER5 immediate early response 5
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP7 insulin-like growth factor binding protein 7
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
JUN jun proto-oncogene
KRT23 keratin 23, type I
LGALS1 lectin, galactoside-binding, soluble, 1
LOXL2 lysyl oxidase-like 2
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MMD monocyte to macrophage differentiation-associated
MSN moesin
MXRA7 matrix-remodelling associated 7
NDRG1 N-myc downstream regulated 1
NELL2 NEL-like 2 (chicken)
NT5E 5'-nucleotidase, ecto (CD73)
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble)
PLAU plasminogen activator, urokinase
PLEK2 pleckstrin 2
PLIN2 perilipin 2
PTPRC protein tyrosine phosphatase, receptor type, C
RBP4 retinol binding protein 4, plasma
RHOC ras homolog family member C
SAT1 spermidine/spermine N1-acetyltransferase 1
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6
SNAI2 snail family zinc finger 2
SOX9 SRY (sex determining region Y)-box 9
STK26 serine/threonine protein kinase 26
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box)
TIMP2 TIMP metallopeptidase inhibitor 2
TMEM158 transmembrane protein 158 (gene/pseudogene)
TPM4 tropomyosin 4
TPSB2 tryptase beta 2 (gene/pseudogene)
UBE2L6 ubiquitin-conjugating enzyme E2L 6
VEGFA vascular endothelial growth factor A
VIM vimentin
VSIG4 V-set and immunoglobulin domain containing 4

decreased expression

Symbol Name
AGR2 anterior gradient 2
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase)
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1
ARMT1 acidic residue methyltransferase 1
ASCL1 achaete-scute family bHLH transcription factor 1
ATAD2 ATPase family, AAA domain containing 2
B3GNT1
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3
C8ORF4 chromosome 8 open reading frame 4
CA12 carbonic anhydrase XII
CCNA2 cyclin A2
CDK1 cyclin-dependent kinase 1
CDK4 cyclin-dependent kinase 4
CLINT1 clathrin interactor 1
CPNE3 copine III
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1
DEPTOR DEP domain containing MTOR-interacting protein
DTL denticleless E3 ubiquitin protein ligase homolog (Drosophila)
DYNLT3 dynein, light chain, Tctex-type 3
EAPP E2F-associated phosphoprotein
EED embryonic ectoderm development
ESR1 estrogen receptor 1
ETNK1 ethanolamine kinase 1
FABP5 fatty acid binding protein 5 (psoriasis-associated)
FEN1 flap structure-specific endonuclease 1
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
G3BP1 GTPase activating protein (SH3 domain) binding protein 1
GATA3 GATA binding protein 3
GREB1 growth regulation by estrogen in breast cancer 1
ICAM3 intercellular adhesion molecule 3
IGF1R insulin-like growth factor 1 receptor
IMP3 IMP3, U3 small nucleolar ribonucleoprotein
KIF2C kinesin family member 2C
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)
MARCKS myristoylated alanine-rich protein kinase C substrate
MELK maternal embryonic leucine zipper kinase
MREG melanoregulin
MSH6 mutS homolog 6
MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
MUC1 mucin 1, cell surface associated
NOLC1 nucleolar and coiled-body phosphoprotein 1
NPY1R neuropeptide Y receptor Y1
NR2F2 nuclear receptor subfamily 2, group F, member 2
NUP62 nucleoporin 62kDa
NUP98 nucleoporin 98kDa
OLFM1 olfactomedin 1
PAICS phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase
PCNA proliferating cell nuclear antigen
PEBP1 phosphatidylethanolamine binding protein 1
PPIF peptidylprolyl isomerase F
PRKCD protein kinase C, delta
PRPF4 pre-mRNA processing factor 4
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
QDPR quinoid dihydropteridine reductase
RAB14 RAB14, member RAS oncogene family
RBM47 RNA binding motif protein 47
RFC2 replication factor C (activator 1) 2, 40kDa
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMC2 structural maintenance of chromosomes 2
SPR sepiapterin reductase (7,8-dihydrobiopterin:NADP+ oxidoreductase)
TARBP1 TAR (HIV-1) RNA binding protein 1
TFF1 trefoil factor 1
TFF3 trefoil factor 3 (intestinal)
TM2D3 TM2 domain containing 3
TMED2 transmembrane emp24 domain trafficking protein 2
TOMM70A translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
TOP2A topoisomerase (DNA) II alpha 170kDa
TSPAN13 tetraspanin 13
TSPYL1 TSPY-like 1
TSPYL5 TSPY-like 5
TUBB tubulin, beta class I
UBE2A ubiquitin-conjugating enzyme E2A
UBE2C ubiquitin-conjugating enzyme E2C
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative)
UCP2 uncoupling protein 2 (mitochondrial, proton carrier)
USP1 ubiquitin specific peptidase 1
XBP1 X-box binding protein 1
ZNF131 zinc finger protein 131