BRD-K00007652_-666_A375_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

99 genes differentially expressed following the BRD-K00007652_-666_A375_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
ACTG2 actin, gamma 2, smooth muscle, enteric
ACTN1 actinin, alpha 1
ADGRE5 adhesion G protein-coupled receptor E5
ADRB2 adrenoceptor beta 2, surface
AHNAK AHNAK nucleoprotein
AKAP12 A kinase (PRKA) anchor protein 12
ALCAM activated leukocyte cell adhesion molecule
AMOTL2 angiomotin like 2
ANKRD27 ankyrin repeat domain 27 (VPS9 domain)
ANXA1 annexin A1
ANXA4 annexin A4
ATF3 activating transcription factor 3
CAPN2 calpain 2, (m/II) large subunit
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CHI3L1 chitinase 3-like 1 (cartilage glycoprotein-39)
CHIC2 cysteine-rich hydrophobic domain 2
CLDN3 claudin 3
CLDN4 claudin 4
CLIC4 chloride intracellular channel 4
CNN1 calponin 1, basic, smooth muscle
COL14A1 collagen, type XIV, alpha 1
CRABP2 cellular retinoic acid binding protein 2
CRYAB crystallin, alpha B
CSRP1 cysteine and glycine-rich protein 1
CYR61 cysteine-rich, angiogenic inducer, 61
DDAH1 dimethylarginine dimethylaminohydrolase 1
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2
DST dystonin
DUSP1 dual specificity phosphatase 1
DUSP10 dual specificity phosphatase 10
FHL2 four and a half LIM domains 2
GABRP gamma-aminobutyric acid (GABA) A receptor, pi
GPRC5A G protein-coupled receptor, class C, group 5, member A
GPRC5B G protein-coupled receptor, class C, group 5, member B
GSN gelsolin
IGFBP4 insulin-like growth factor binding protein 4
IGFBP7 insulin-like growth factor binding protein 7
JUN jun proto-oncogene
KCNK1 potassium channel, two pore domain subfamily K, member 1
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1
KLK5 kallikrein-related peptidase 5
KRT18 keratin 18, type I
KRT7 keratin 7, type II
LGALS1 lectin, galactoside-binding, soluble, 1
LMOD1 leiomodin 1 (smooth muscle)
LXN latexin
MEST mesoderm specific transcript
MET MET proto-oncogene, receptor tyrosine kinase
MFAP5 microfibrillar associated protein 5
MMP7 matrix metallopeptidase 7
MT2A metallothionein 2A
MXRA7 matrix-remodelling associated 7
MYLK myosin light chain kinase
NLRP2 NLR family, pyrin domain containing 2
OSBPL10 oxysterol binding protein-like 10
OXSR1 oxidative stress responsive 1
OXTR oxytocin receptor
PALLD palladin, cytoskeletal associated protein
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDLIM5 PDZ and LIM domain 5
PEG10 paternally expressed 10
PHLDA2 pleckstrin homology-like domain, family A, member 2
PLAU plasminogen activator, urokinase
PPA1 pyrophosphatase (inorganic) 1
PTGDS prostaglandin D2 synthase 21kDa (brain)
RAB29 RAB29, member RAS oncogene family
RAMP1 receptor (G protein-coupled) activity modifying protein 1
RARRES1 retinoic acid receptor responder (tazarotene induced) 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
SAMD4A sterile alpha motif domain containing 4A
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6
SMAD3 SMAD family member 3
SOX9 SRY (sex determining region Y)-box 9
SYNM synemin, intermediate filament protein
TBC1D31 TBC1 domain family, member 31
TGFB2 transforming growth factor, beta 2
TM4SF1 transmembrane 4 L six family member 1
TM4SF4 transmembrane 4 L six family member 4
TPD52L1 tumor protein D52-like 1
TPM2 tropomyosin 2 (beta)
TPM4 tropomyosin 4
VCL vinculin

decreased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADRBK1 adrenergic, beta, receptor kinase 1
AKAP8 A kinase (PRKA) anchor protein 8
BAMBI BMP and activin membrane-bound inhibitor
CD99 CD99 molecule
DDIT4 DNA-damage-inducible transcript 4
EDEM1 ER degradation enhancer, mannosidase alpha-like 1
HES1 hes family bHLH transcription factor 1
HIST1H2BK histone cluster 1, H2bk
ID3 inhibitor of DNA binding 3, dominant negative helix-loop-helix protein
SCD stearoyl-CoA desaturase (delta-9-desaturase)
SDC2 syndecan 2
SEPT10 septin 10
TCF4 transcription factor 4