BRD-A94756469_-666_HT29_6.0_h_10.0_um Gene Set

Dataset LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules
Category transcriptomics
Type small molecule perturbation
Description small molecule perturbation identified as [perturbation ID]_[perturbagen]_[cell line]_[time]_[time unit]_[dose]_[dose unit] (LINCS L1000 Connectivity Map)
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Genes

197 genes differentially expressed following the BRD-A94756469_-666_HT29_6.0_h_10.0_um small molecule perturbation from the LINCS L1000 CMAP Signatures of Differentially Expressed Genes for Small Molecules dataset.

increased expression

Symbol Name
1060P11.3 killer cell immunoglobulin-like receptor, three domains, pseudogene
ADM adrenomedullin
AKAP12 A kinase (PRKA) anchor protein 12
ALDH1A3 aldehyde dehydrogenase 1 family, member A3
APOLD1 apolipoprotein L domain containing 1
AREG amphiregulin
ATF3 activating transcription factor 3
BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1
BTG1 B-cell translocation gene 1, anti-proliferative
BTG2 BTG family, member 2
BTG3 BTG family, member 3
CCNL1 cyclin L1
CD24 CD24 molecule
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group)
CD59 CD59 molecule, complement regulatory protein
CD9 CD9 molecule
CDC25A cell division cycle 25A
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
COL15A1 collagen, type XV, alpha 1
CST6 cystatin E/M
CTGF connective tissue growth factor
CXCL8 chemokine (C-X-C motif) ligand 8
CYP51A1 cytochrome P450, family 51, subfamily A, polypeptide 1
CYR61 cysteine-rich, angiogenic inducer, 61
DHCR7 7-dehydrocholesterol reductase
DNMBP dynamin binding protein
DUSP1 dual specificity phosphatase 1
DUSP5 dual specificity phosphatase 5
DUSP6 dual specificity phosphatase 6
DYNLT1 dynein, light chain, Tctex-type 1
EGFR epidermal growth factor receptor
EGR1 early growth response 1
EGR3 early growth response 3
EMP1 epithelial membrane protein 1
EMP3 epithelial membrane protein 3
EREG epiregulin
EZR ezrin
F2RL1 coagulation factor II (thrombin) receptor-like 1
FADS1 fatty acid desaturase 1
FAM3C family with sequence similarity 3, member C
FAM46A family with sequence similarity 46, member A
FASN fatty acid synthase
FNDC3B fibronectin type III domain containing 3B
FOSB FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 FOS-like antigen 1
FST follistatin
FUCA1 fucosidase, alpha-L- 1, tissue
GADD45A growth arrest and DNA-damage-inducible, alpha
GADD45B growth arrest and DNA-damage-inducible, beta
GNG12 guanine nucleotide binding protein (G protein), gamma 12
GPRC5A G protein-coupled receptor, class C, group 5, member A
GSTM3 glutathione S-transferase mu 3 (brain)
HAL histidine ammonia-lyase
HBEGF heparin-binding EGF-like growth factor
HES1 hes family bHLH transcription factor 1
HHEX hematopoietically expressed homeobox
HIST1H1C histone cluster 1, H1c
HLA-B major histocompatibility complex, class I, B
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble)
HOMER3 homer scaffolding protein 3
IER2 immediate early response 2
IER3 immediate early response 3
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3
IGFBP5 insulin-like growth factor binding protein 5
IGFBP7 insulin-like growth factor binding protein 7
IL1R2 interleukin 1 receptor, type II
IL6 interleukin 6
IL6ST interleukin 6 signal transducer
INPP1 inositol polyphosphate-1-phosphatase
INSIG1 insulin induced gene 1
JUN jun proto-oncogene
JUNB jun B proto-oncogene
JUND jun D proto-oncogene
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15
KDM6B lysine (K)-specific demethylase 6B
KLF6 Kruppel-like factor 6
LDLR low density lipoprotein receptor
MAFF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
MAN1A1 mannosidase, alpha, class 1A, member 1
MAP1LC3B microtubule-associated protein 1 light chain 3 beta
MCL1 myeloid cell leukemia 1
MIR22HG MIR22 host gene
MSMO1 methylsterol monooxygenase 1
MT1G metallothionein 1G
MT1X metallothionein 1X
MT2A metallothionein 2A
MTSS1 metastasis suppressor 1
NEAT1 nuclear paraspeckle assembly transcript 1 (non-protein coding)
NPC1 Niemann-Pick disease, type C1
NR4A1 nuclear receptor subfamily 4, group A, member 1
NR4A3 nuclear receptor subfamily 4, group A, member 3
NT5E 5'-nucleotidase, ecto (CD73)
NTRK2 neurotrophic tyrosine kinase, receptor, type 2
NUPL1 nucleoporin like 1
PER1 period circadian clock 1
PHLDA1 pleckstrin homology-like domain, family A, member 1
PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1
PPIF peptidylprolyl isomerase F
PPP1R15A protein phosphatase 1, regulatory subunit 15A
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
PTPN12 protein tyrosine phosphatase, non-receptor type 12
RASA1 RAS p21 protein activator (GTPase activating protein) 1
RGS2 regulator of G-protein signaling 2
RHOB ras homolog family member B
RRP12 ribosomal RNA processing 12 homolog (S. cerevisiae)
S100A12 S100 calcium binding protein A12
SAT1 spermidine/spermine N1-acetyltransferase 1
SERPINA5 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2
SFRP1 secreted frizzled-related protein 1
SLC19A2 solute carrier family 19 (thiamine transporter), member 2
SMAD3 SMAD family member 3
SOX4 SRY (sex determining region Y)-box 4
STK17A serine/threonine kinase 17a
STX12 syntaxin 12
SUB1 SUB1 homolog (S. cerevisiae)
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa
TCL1A T-cell leukemia/lymphoma 1A
THBS1 thrombospondin 1
TIMP3 TIMP metallopeptidase inhibitor 3
TIPARP TCDD-inducible poly(ADP-ribose) polymerase
TNFRSF12A tumor necrosis factor receptor superfamily, member 12A
TRIB1 tribbles pseudokinase 1
TSC22D2 TSC22 domain family, member 2
TUFT1 tuftelin 1
TXNIP thioredoxin interacting protein
VEGFC vascular endothelial growth factor C
WEE1 WEE1 G2 checkpoint kinase
XIST X inactive specific transcript (non-protein coding)
ZBED2 zinc finger, BED-type containing 2
ZFP36 ZFP36 ring finger protein

decreased expression

Symbol Name
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
AKR1C3 aldo-keto reductase family 1, member C3
ALDH3A1 aldehyde dehydrogenase 3 family, member A1
ATP1A2 ATPase, Na+/K+ transporting, alpha 2 polypeptide
BHLHE41 basic helix-loop-helix family, member e41
C2CD5 C2 calcium-dependent domain containing 5
C6ORF62 chromosome 6 open reading frame 62
CCNF cyclin F
CEBPA CCAAT/enhancer binding protein (C/EBP), alpha
CENPA centromere protein A
CFB complement factor B
CSK c-src tyrosine kinase
CSRP1 cysteine and glycine-rich protein 1
CTBP1 C-terminal binding protein 1
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase)
DEPDC1 DEP domain containing 1
DIXDC1 DIX domain containing 1
DLGAP5 discs, large (Drosophila) homolog-associated protein 5
DPYSL2 dihydropyrimidinase-like 2
DPYSL3 dihydropyrimidinase-like 3
EIF5 eukaryotic translation initiation factor 5
FMO2 flavin containing monooxygenase 2 (non-functional)
FNBP1 formin binding protein 1
GATA2 GATA binding protein 2
GPX2 glutathione peroxidase 2
HMGN3 high mobility group nucleosomal binding domain 3
HPGD hydroxyprostaglandin dehydrogenase 15-(NAD)
HSPA1A heat shock 70kDa protein 1A
HSPA8 heat shock 70kDa protein 8
IDH1 isocitrate dehydrogenase 1 (NADP+), soluble
IGKV1-5 immunoglobulin kappa variable 1-5
ITGB1BP1 integrin beta 1 binding protein 1
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
LIMCH1 LIM and calponin homology domains 1
LPL lipoprotein lipase
LY6E lymphocyte antigen 6 complex, locus E
MREG melanoregulin
MYH10 myosin, heavy chain 10, non-muscle
NEFH neurofilament, heavy polypeptide
PDZD2 PDZ domain containing 2
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta
PLK1 polo-like kinase 1
PRUNE2 prune homolog 2 (Drosophila)
PSCA prostate stem cell antigen
PSMG1 proteasome (prosome, macropain) assembly chaperone 1
PTP4A3 protein tyrosine phosphatase type IVA, member 3
RAP2A RAP2A, member of RAS oncogene family
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans)
STEAP3 STEAP family member 3, metalloreductase
STK38 serine/threonine kinase 38
TARP TCR gamma alternate reading frame protein
TBC1D31 TBC1 domain family, member 31
THEM6 thioesterase superfamily member 6
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
TMEM176A transmembrane protein 176A
TMEM176B transmembrane protein 176B
TNFRSF21 tumor necrosis factor receptor superfamily, member 21
TRAK2 trafficking protein, kinesin binding 2
TSEN2 TSEN2 tRNA splicing endonuclease subunit
TSPAN8 tetraspanin 8
TYROBP TYRO protein tyrosine kinase binding protein
USP34 ubiquitin specific peptidase 34
ZW10 zw10 kinetochore protein